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Protein

BMP/retinoic acid-inducible neural-specific protein 3

Gene

BRINP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
BMP/retinoic acid-inducible neural-specific protein 3
Alternative name(s):
DBCCR1-like protein 1
Gene namesi
Name:BRINP3
Synonyms:DBCCR1L, DBCCR1L1, FAM5C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:22393. BRINP3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671896.

Polymorphism and mutation databases

BioMutaiFAM5C.
DMDMi74749831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 766733BMP/retinoic acid-inducible neural-specific protein 3PRO_0000045774Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence analysis
Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence analysis
Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence analysis
Glycosylationi562 – 5621N-linked (GlcNAc...)Sequence analysis
Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence analysis
Glycosylationi641 – 6411N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ76B58.
PaxDbiQ76B58.
PRIDEiQ76B58.

PTM databases

iPTMnetiQ76B58.
PhosphoSiteiQ76B58.

Expressioni

Tissue specificityi

Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues.3 Publications

Gene expression databases

BgeeiQ76B58.
CleanExiHS_FAM5C.
ExpressionAtlasiQ76B58. baseline and differential.
GenevisibleiQ76B58. HS.

Organism-specific databases

HPAiHPA054693.

Interactioni

Protein-protein interaction databases

BioGridi130891. 17 interactions.
STRINGi9606.ENSP00000356432.

Structurei

3D structure databases

ProteinModelPortaliQ76B58.
SMRiQ76B58. Positions 98-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 264191MACPFAdd
BLAST

Sequence similaritiesi

Belongs to the BRINP family.Curated
Contains 1 MACPF domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF4X. Eukaryota.
ENOG410XQ74. LUCA.
GeneTreeiENSGT00390000008571.
HOGENOMiHOG000049122.
HOVERGENiHBG081412.
InParanoidiQ76B58.
OMAiCHCGPKF.
OrthoDBiEOG764720.
PhylomeDBiQ76B58.
TreeFamiTF331600.

Family and domain databases

InterProiIPR033237. BRINP.
IPR009030. Growth_fac_rcpt_.
IPR020864. MACPF.
[Graphical view]
PANTHERiPTHR15564. PTHR15564. 1 hit.
PfamiPF01823. MACPF. 1 hit.
[Graphical view]
SMARTiSM00457. MACPF. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q76B58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIWRSRAGAE LFSLMALWEW IALSLHCWVL AVAAVSDQHA TSPFDWLLSD
60 70 80 90 100
KGPFHRSQEY TDFVDRSRQG FSTRYKIYRE FGRWKVNNLA VERRNFLGSP
110 120 130 140 150
LPLAPEFFRN IRLLGRRPTL QQITENLIKK YGTHFLLSAT LGGEESLTIF
160 170 180 190 200
VDKRKLSKRA EGSDSTTNSS SVTLETLHQL AASYFIDRDS TLRRLHHIQI
210 220 230 240 250
ASTAIKVTET RTGPLGCSNY DNLDSVSSVL VQSPENKIQL QGLQVLLPDY
260 270 280 290 300
LQERFVQAAL SYIACNSEGE FICKENDCWC HCGPKFPECN CPSMDIQAME
310 320 330 340 350
ENLLRITETW KAYNSDFEES DEFKLFMKRL PMNYFLNTST IMHLWTMDSN
360 370 380 390 400
FQRRYEQLEN SMKQLFLKAQ KIVHKLFSLS KRCHKQPLIS LPRQRTSTYW
410 420 430 440 450
LTRIQSFLYC NENGLLGSFS EETHSCTCPN DQVVCTAFLP CTVGDASACL
460 470 480 490 500
TCAPDNRTRC GTCNTGYMLS QGLCKPEVAE STDHYIGFET DLQDLEMKYL
510 520 530 540 550
LQKTDRRIEV HAIFISNDMR LNSWFDPSWR KRMLLTLKSN KYKSSLVHMI
560 570 580 590 600
LGLSLQICLT KNSTLEPVLA VYVNPFGGSH SESWFMPVNE NSFPDWERTK
610 620 630 640 650
LDLPLQCYNW TLTLGNKWKT FFETVHIYLR SRIKSNGPNG NESIYYEPLE
660 670 680 690 700
FIDPSRNLGY MKINNIQVFG YSMHFDPEAI RDLILQLDYP YTQGSQDSAL
710 720 730 740 750
LQLLEIRDRV NKLSPPGQRR LDLFSCLLRH RLKLSTSEVV RIQSALQAFN
760
AKLPNTMDYD TTKLCS
Length:766
Mass (Da):88,445
Last modified:July 5, 2004 - v1
Checksum:iD325EB7E9F416FB3
GO
Isoform 2 (identifier: Q76B58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MIWRSRAGAE...AVAAVSDQHA → MPQAPSTGSS...RDLAQDTRYT
     41-142: Missing.

Note: No experimental confirmation available.
Show »
Length:664
Mass (Da):76,299
Checksum:i2A9FC9B061911025
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti422 – 4221E → K in AAD09521 (PubMed:16710414).Curated
Sequence conflicti534 – 5341L → F in AAD09521 (PubMed:16710414).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4040MIWRS…SDQHA → MPQAPSTGSSLIRDPSIAHR NTQILWTEAGRDLAQDTRYT in isoform 2. 1 PublicationVSP_055545Add
BLAST
Alternative sequencei41 – 142102Missing in isoform 2. 1 PublicationVSP_055546Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB111893 mRNA. Translation: BAD04066.1.
AK123024 mRNA. Translation: BAG53853.1.
AK294365 mRNA. Translation: BAH11746.1.
AL365402, AL354771, AL391645 Genomic DNA. Translation: CAH73887.1.
AL354771, AL365402, AL391645 Genomic DNA. Translation: CAI15426.1.
AL391645, AL354771, AL365402 Genomic DNA. Translation: CAI15441.1.
CH471067 Genomic DNA. Translation: EAW91222.1.
BC105052 mRNA. Translation: AAI05053.1.
BC105054 mRNA. Translation: AAI05055.1.
U67037 mRNA. Translation: AAD09521.1.
CCDSiCCDS1373.1. [Q76B58-1]
RefSeqiNP_001304117.1. NM_001317188.1. [Q76B58-2]
NP_950252.1. NM_199051.2. [Q76B58-1]
XP_005245174.1. XM_005245117.1. [Q76B58-1]
XP_005245175.1. XM_005245118.3. [Q76B58-1]
XP_005245177.1. XM_005245120.2. [Q76B58-1]
XP_011507778.1. XM_011509476.1. [Q76B58-2]
UniGeneiHs.65765.

Genome annotation databases

EnsembliENST00000367462; ENSP00000356432; ENSG00000162670. [Q76B58-1]
GeneIDi339479.
KEGGihsa:339479.
UCSCiuc001gse.2. human. [Q76B58-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB111893 mRNA. Translation: BAD04066.1.
AK123024 mRNA. Translation: BAG53853.1.
AK294365 mRNA. Translation: BAH11746.1.
AL365402, AL354771, AL391645 Genomic DNA. Translation: CAH73887.1.
AL354771, AL365402, AL391645 Genomic DNA. Translation: CAI15426.1.
AL391645, AL354771, AL365402 Genomic DNA. Translation: CAI15441.1.
CH471067 Genomic DNA. Translation: EAW91222.1.
BC105052 mRNA. Translation: AAI05053.1.
BC105054 mRNA. Translation: AAI05055.1.
U67037 mRNA. Translation: AAD09521.1.
CCDSiCCDS1373.1. [Q76B58-1]
RefSeqiNP_001304117.1. NM_001317188.1. [Q76B58-2]
NP_950252.1. NM_199051.2. [Q76B58-1]
XP_005245174.1. XM_005245117.1. [Q76B58-1]
XP_005245175.1. XM_005245118.3. [Q76B58-1]
XP_005245177.1. XM_005245120.2. [Q76B58-1]
XP_011507778.1. XM_011509476.1. [Q76B58-2]
UniGeneiHs.65765.

3D structure databases

ProteinModelPortaliQ76B58.
SMRiQ76B58. Positions 98-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130891. 17 interactions.
STRINGi9606.ENSP00000356432.

PTM databases

iPTMnetiQ76B58.
PhosphoSiteiQ76B58.

Polymorphism and mutation databases

BioMutaiFAM5C.
DMDMi74749831.

Proteomic databases

MaxQBiQ76B58.
PaxDbiQ76B58.
PRIDEiQ76B58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367462; ENSP00000356432; ENSG00000162670. [Q76B58-1]
GeneIDi339479.
KEGGihsa:339479.
UCSCiuc001gse.2. human. [Q76B58-1]

Organism-specific databases

CTDi339479.
GeneCardsiBRINP3.
HGNCiHGNC:22393. BRINP3.
HPAiHPA054693.
neXtProtiNX_Q76B58.
PharmGKBiPA142671896.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF4X. Eukaryota.
ENOG410XQ74. LUCA.
GeneTreeiENSGT00390000008571.
HOGENOMiHOG000049122.
HOVERGENiHBG081412.
InParanoidiQ76B58.
OMAiCHCGPKF.
OrthoDBiEOG764720.
PhylomeDBiQ76B58.
TreeFamiTF331600.

Miscellaneous databases

GenomeRNAii339479.
PROiQ76B58.

Gene expression databases

BgeeiQ76B58.
CleanExiHS_FAM5C.
ExpressionAtlasiQ76B58. baseline and differential.
GenevisibleiQ76B58. HS.

Family and domain databases

InterProiIPR033237. BRINP.
IPR009030. Growth_fac_rcpt_.
IPR020864. MACPF.
[Graphical view]
PANTHERiPTHR15564. PTHR15564. 1 hit.
PfamiPF01823. MACPF. 1 hit.
[Graphical view]
SMARTiSM00457. MACPF. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of novel gene, DBCCR1L."
    Imoto I., Inazawa J.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala and Brain.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. "Expression of novel gene mapped on chromosome 1q25."
    Park S.H., Kim C., Kang Y.H., Chung H.S., Kim H.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 324-541 (ISOFORM 1/2).
    Tissue: Brain.
  7. "Bone morphogenetic protein and retinoic acid-inducible neural specific protein-3 is expressed in gonadotrope cell pituitary adenomas and induces proliferation, migration, and invasion."
    Shorts-Cary L., Xu M., Ertel J., Kleinschmidt-Demasters B.K., Lillehei K., Matsuoka I., Nielsen-Preiss S., Wierman M.E.
    Endocrinology 148:967-975(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  8. Cited for: TISSUE SPECIFICITY.
  9. "Expression of the FAM5C in tongue squamous cell carcinoma."
    Kuroiwa T., Yamamoto N., Onda T., Shibahara T.
    Oncol. Rep. 22:1005-1011(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBRNP3_HUMAN
AccessioniPrimary (citable) accession number: Q76B58
Secondary accession number(s): B3KVP1
, B7Z260, O95726, Q2M330
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.