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Protein

ATP-binding cassette sub-family F member 1

Gene

ABCF1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi298 – 3058ATP 1PROSITE-ProRule annotation
Nucleotide bindingi620 – 6278ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SSC-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family F member 1
Gene namesi
Name:ABCF1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 7

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleusnucleoplasm By similarity
  • Nucleus envelope By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807ATP-binding cassette sub-family F member 1PRO_0000093321Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei106 – 1061PhosphoserineBy similarity
Modified residuei110 – 1101Phosphoserine; by CK2By similarity
Modified residuei141 – 1411Phosphoserine; by CK2By similarity
Modified residuei167 – 1671PhosphoserineBy similarity
Cross-linki535 – 535Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki544 – 544Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei557 – 5571PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated at phosphoserine and phosphothreonine. Phosphorylation on Ser-110 and Ser-141 by CK2; inhibits association of EIF2 with ribosomes (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ767L0.
PeptideAtlasiQ767L0.
PRIDEiQ767L0.

Expressioni

Gene expression databases

GenevisibleiQ767L0. SS.

Interactioni

Subunit structurei

Interacts (via N-terminus) with EIF2S1; the interaction is independent of its phosphorylated status. Associates (via both ABC transporter domains) with the ribosomes (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000028530.

Structurei

3D structure databases

ProteinModelPortaliQ767L0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini266 – 510245ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini587 – 802216ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi112 – 1154Poly-Glu
Compositional biasi142 – 1487Poly-Glu

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0927. Eukaryota.
COG0488. LUCA.
GeneTreeiENSGT00630000089843.
HOGENOMiHOG000271637.
HOVERGENiHBG050440.
InParanoidiQ767L0.
KOiK06184.
OrthoDBiEOG7WDN23.
TreeFamiTF105207.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR032781. ABC_tran_Xtn.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
PF12848. ABC_tran_Xtn. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q767L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKGPKQQPP EPEWIGDGES TSPTDKVVKK GKKDKKTKKT FFEELAVEDR
60 70 80 90 100
QAGEEEKVLK EKEQQQQHQQ QQQKKKRDTR KGRRKKDVDD DDGEEKELME
110 120 130 140 150
RLKKLSVPAS DEEEEAPAPV PRGGKKNKGG NVFAALIQDQ SEEEEEEEKH
160 170 180 190 200
PPKPAKPEKN RINKAVSQEQ QPGPKGRKGK EEKSKGKAKP QNKFAALDDE
210 220 230 240 250
EEQDEEEIKE KEPPKQGKEK AKKAEQMEYE RQVASLKAAN AAENDFSVSQ
260 270 280 290 300
AEMSSRQAML ENASDIKLEK FSISAHGKEL FVNADLYIVA GRRYGLVGPN
310 320 330 340 350
GKGKTTLLKH IANRALSIPP NIDVLLCEQE VVADETPAVQ AVLRADTKRL
360 370 380 390 400
KLLEEERRLQ GQLEQGDDTA ADRLEKVYEE LRATGAAAAE AKARRILAGL
410 420 430 440 450
GFDPEMQNRP TQKFSGGWRM RVSLARALFM EPTLLMLDEP TNHLDLNAVI
460 470 480 490 500
WLNNYLQGWR KTLLIVSHDQ GFLDDVCTDI IHLDAQRLHY YRGNYMTFKK
510 520 530 540 550
MYQQKQKELL KQYEKQEKKL KELKAGGKST KQAEKQTKEA LTRKQQKCRR
560 570 580 590 600
KNQDEESQEA PELLKRPKEY TVRFTFPDPP PLSPPVLGLH GVTFGYEGQK
610 620 630 640 650
PLFKNLDFGI DMDSRICIVG PNGVGKSTLL LLLTGKLTPT RGEMRKNHRL
660 670 680 690 700
KIGFFNQQYA EQLRMEETPT EYLQRGFNLP YQDARKCLGR FGLESHAHTI
710 720 730 740 750
QICKLSGGQK ARVVFAELAC REPDVLILDE PTNNLDIESI DALGEAINEY
760 770 780 790 800
KGAVIVVSHD ARLITETNCQ LWVVEEQSVS QIDGDFDDYK REVLEALGEV

MVSRPRE
Length:807
Mass (Da):91,637
Last modified:July 5, 2004 - v1
Checksum:iA12F61517E5C7987
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB113357 Genomic DNA. Translation: BAD08439.1.
RefSeqiNP_001116541.1. NM_001123069.1.
UniGeneiSsc.1504.

Genome annotation databases

EnsembliENSSSCT00000001462; ENSSSCP00000001420; ENSSSCG00000001346.
GeneIDi100144452.
KEGGissc:100144452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB113357 Genomic DNA. Translation: BAD08439.1.
RefSeqiNP_001116541.1. NM_001123069.1.
UniGeneiSsc.1504.

3D structure databases

ProteinModelPortaliQ767L0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000028530.

Proteomic databases

PaxDbiQ767L0.
PeptideAtlasiQ767L0.
PRIDEiQ767L0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000001462; ENSSSCP00000001420; ENSSSCG00000001346.
GeneIDi100144452.
KEGGissc:100144452.

Organism-specific databases

CTDi23.

Phylogenomic databases

eggNOGiKOG0927. Eukaryota.
COG0488. LUCA.
GeneTreeiENSGT00630000089843.
HOGENOMiHOG000271637.
HOVERGENiHBG050440.
InParanoidiQ767L0.
KOiK06184.
OrthoDBiEOG7WDN23.
TreeFamiTF105207.

Enzyme and pathway databases

ReactomeiR-SSC-382556. ABC-family proteins mediated transport.

Gene expression databases

GenevisibleiQ767L0. SS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR032781. ABC_tran_Xtn.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
PF12848. ABC_tran_Xtn. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequencing analysis of the swine 433-kb genomic segment located between the non-classical and classical SLA class I gene clusters."
    Shigenari A., Ando A., Renard C., Chardon P., Shiina T., Kulski J.K., Yasue H., Inoko H.
    Immunogenetics 55:695-705(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Large white.

Entry informationi

Entry nameiABCF1_PIG
AccessioniPrimary (citable) accession number: Q767L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.