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Protein

ATP-binding cassette sub-family F member 1

Gene

ABCF1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi298 – 305ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi620 – 627ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SSC-382556 ABC-family proteins mediated transport

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family F member 1
Gene namesi
Name:ABCF1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933211 – 807ATP-binding cassette sub-family F member 1Add BLAST807

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineBy similarity1
Modified residuei106PhosphoserineBy similarity1
Modified residuei110Phosphoserine; by CK2By similarity1
Modified residuei141Phosphoserine; by CK2By similarity1
Modified residuei167PhosphoserineBy similarity1
Modified residuei557PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated at phosphoserine and phosphothreonine. Phosphorylation on Ser-110 and Ser-141 by CK2; inhibits association of EIF2 with ribosomes (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ767L0
PeptideAtlasiQ767L0
PRIDEiQ767L0

Expressioni

Gene expression databases

BgeeiENSSSCG00000001346
ExpressionAtlasiQ767L0 baseline and differential
GenevisibleiQ767L0 SS

Interactioni

Subunit structurei

Interacts (via N-terminus) with EIF2S1; the interaction is independent of its phosphorylated status. Associates (via both ABC transporter domains) with the ribosomes (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000028530

Structurei

3D structure databases

ProteinModelPortaliQ767L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini266 – 510ABC transporter 1PROSITE-ProRule annotationAdd BLAST245
Domaini587 – 802ABC transporter 2PROSITE-ProRule annotationAdd BLAST216

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi112 – 115Poly-Glu4
Compositional biasi142 – 148Poly-Glu7

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0927 Eukaryota
COG0488 LUCA
GeneTreeiENSGT00630000089843
HOGENOMiHOG000271637
HOVERGENiHBG050440
InParanoidiQ767L0
KOiK06184
TreeFamiTF105207

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR032781 ABC_tran_Xtn
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
PF12848 ABC_tran_Xtn, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q767L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKGPKQQPP EPEWIGDGES TSPTDKVVKK GKKDKKTKKT FFEELAVEDR
60 70 80 90 100
QAGEEEKVLK EKEQQQQHQQ QQQKKKRDTR KGRRKKDVDD DDGEEKELME
110 120 130 140 150
RLKKLSVPAS DEEEEAPAPV PRGGKKNKGG NVFAALIQDQ SEEEEEEEKH
160 170 180 190 200
PPKPAKPEKN RINKAVSQEQ QPGPKGRKGK EEKSKGKAKP QNKFAALDDE
210 220 230 240 250
EEQDEEEIKE KEPPKQGKEK AKKAEQMEYE RQVASLKAAN AAENDFSVSQ
260 270 280 290 300
AEMSSRQAML ENASDIKLEK FSISAHGKEL FVNADLYIVA GRRYGLVGPN
310 320 330 340 350
GKGKTTLLKH IANRALSIPP NIDVLLCEQE VVADETPAVQ AVLRADTKRL
360 370 380 390 400
KLLEEERRLQ GQLEQGDDTA ADRLEKVYEE LRATGAAAAE AKARRILAGL
410 420 430 440 450
GFDPEMQNRP TQKFSGGWRM RVSLARALFM EPTLLMLDEP TNHLDLNAVI
460 470 480 490 500
WLNNYLQGWR KTLLIVSHDQ GFLDDVCTDI IHLDAQRLHY YRGNYMTFKK
510 520 530 540 550
MYQQKQKELL KQYEKQEKKL KELKAGGKST KQAEKQTKEA LTRKQQKCRR
560 570 580 590 600
KNQDEESQEA PELLKRPKEY TVRFTFPDPP PLSPPVLGLH GVTFGYEGQK
610 620 630 640 650
PLFKNLDFGI DMDSRICIVG PNGVGKSTLL LLLTGKLTPT RGEMRKNHRL
660 670 680 690 700
KIGFFNQQYA EQLRMEETPT EYLQRGFNLP YQDARKCLGR FGLESHAHTI
710 720 730 740 750
QICKLSGGQK ARVVFAELAC REPDVLILDE PTNNLDIESI DALGEAINEY
760 770 780 790 800
KGAVIVVSHD ARLITETNCQ LWVVEEQSVS QIDGDFDDYK REVLEALGEV

MVSRPRE
Length:807
Mass (Da):91,637
Last modified:July 5, 2004 - v1
Checksum:iA12F61517E5C7987
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB113357 Genomic DNA Translation: BAD08439.1
RefSeqiNP_001116541.1, NM_001123069.1
UniGeneiSsc.1504

Genome annotation databases

EnsembliENSSSCT00000001462; ENSSSCP00000001420; ENSSSCG00000001346
GeneIDi100144452
KEGGissc:100144452

Similar proteinsi

Entry informationi

Entry nameiABCF1_PIG
AccessioniPrimary (citable) accession number: Q767L0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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