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Protein

Protein Vpx

Gene

vpx

Organism
Human immunodeficiency virus type 2 subtype B (isolate UC1) (HIV-2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Vpx
Alternative name(s):
Viral protein X
X ORF protein
Gene namesi
Name:vpx
OrganismiHuman immunodeficiency virus type 2 subtype B (isolate UC1) (HIV-2)
Taxonomic identifieri388822 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007428 Componenti: Genome

Subcellular locationi

  • Virion
  • Host nucleus

  • Note: Nuclear just after virion uncoating, or if expressed in the absence of unprocessed GAG.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002467721 – 111Protein VpxAdd BLAST111

Interactioni

Subunit structurei

Interacts with the P6 region of unprocessed GAG. Interacts with host VPRBP/DCAF1, leading to change substrate specificity of the CUL4A-DDB1 E3 ligase complex (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ76636.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi64 – 71Nuclear localization signalBy similarity8

Sequence similaritiesi

Belongs to the lentivirus VPX protein family.Curated

Family and domain databases

InterProiIPR000012. RetroV_VpR/X.
[Graphical view]
PfamiPF00522. VPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q76636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPRERVPPG NSDEETIGEA FDWLERTITE LNRVAVNHLP RELIFQVWQR
60 70 80 90 100
CWAYWREEQG MSSSYTKYRY LLLMQKAMFV HYTKGCRCLQ EGHGPGGWRS
110
GPPPPPPPGL A
Length:111
Mass (Da):12,904
Last modified:November 1, 1996 - v1
Checksum:iCF152CDB66C0E55C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07625 Genomic RNA. Translation: AAA43944.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07625 Genomic RNA. Translation: AAA43944.1.

3D structure databases

ProteinModelPortaliQ76636.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000012. RetroV_VpR/X.
[Graphical view]
PfamiPF00522. VPR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVPX_HV2UC
AccessioniPrimary (citable) accession number: Q76636
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.