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Protein

Protein Vpr

Gene

vpr

Organism
Human immunodeficiency virus 2
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Stimulates gene expression driven by the HIV-2 LTR. Prevents infected cells from undergoing mitosis and proliferating, by inducing arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest creates a favorable environment for maximizing viral expression and production.UniRule annotation

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation
Biological processCell cycleUniRule annotation, Host-virus interactionUniRule annotationSAAS annotation, Transcription, Transcription regulationUniRule annotation, Viral penetration into host nucleusUniRule annotation, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Protein VprUniRule annotation
Alternative name(s):
Viral protein RUniRule annotation
Gene namesi
Name:vprUniRule annotationImported
OrganismiHuman immunodeficiency virus 2Imported
Taxonomic identifieri11709 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host nucleus SAAS annotation
  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleusUniRule annotationSAAS annotation, VirionUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ76624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR000012. RetroV_VpR/X.
PfamiView protein in Pfam
PF00522. VPR. 1 hit.
PRINTSiPR00444. HIVVPRVPX.

Sequencei

Sequence statusi: Complete.

Q76624-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEAPTELPP EDGTPPREPG DEWVIEILRE ITEEALKHFD RSLLTALGRH
60 70 80 90 100
IYTRHGDTLE GARELIRILQ RALFTHFRAG CGHSRIGQTR GGNPLSAIPT

PRSMQ
Length:105
Mass (Da):11,792
Last modified:November 1, 1996 - v1
Checksum:iC0A55343485984B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48731 Genomic RNA. Translation: CAA88624.1.
PIRiS53095.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ76624_9HIV2
AccessioniPrimary (citable) accession number: Q76624
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)