Q765P7 (MTSSL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MTSS1-like protein

Alternative name(s):
Actin-bundling with BAIAP2 homology protein 1
Short name=ABBA-1

Gene names

Name:

MTSS1L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	747 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function in actin bundling. Ref.1
Sequence similarities	Belongs to the MTSS1 family. Contains 1 IMD (IRSp53/MIM homology) domain. Contains 1 WH2 domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Ligand	Actin-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	filopodium assembly Inferred from electronic annotation. Source: InterPro signal transduction Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q765P7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q765P7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     153-155: Missing.
     264-294: SPSSSSSRKSSMCSAPSSSSSAKGGGAPWPG → VPSEPFVSFLSVRFWKNSPLLPAPSTPSSPI
     295-747: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 747	747	MTSS1-like protein		PRO_0000319610
Regions
	Domain	1 – 252	252	IMD
	Domain	719 – 736	18	WH2
	Coiled coil	135 – 159	25	Potential
	Compositional bias	252 – 383	132	Ser-rich
Amino acid modifications
	Modified residue	260	1	Phosphothreonine By similarity
	Modified residue	264	1	Phosphoserine By similarity
	Modified residue	441	1	Phosphoserine Ref.5 Ref.7
	Modified residue	456	1	Phosphoserine By similarity
	Modified residue	579	1	Phosphoserine Ref.5
	Modified residue	601	1	Phosphoserine Ref.4
	Modified residue	612	1	Phosphoserine Ref.5
	Modified residue	624	1	Phosphoserine Ref.5
	Modified residue	634	1	Phosphoserine Ref.5
	Modified residue	639	1	Phosphoserine Ref.4 Ref.5
	Modified residue	643	1	Phosphothreonine Ref.4
Natural variations
	Alternative sequence	153 – 155	3	Missing in isoform 2.		VSP_031513
	Alternative sequence	264 – 294	31	SPSSS…APWPG → VPSEPFVSFLSVRFWKNSPL LPAPSTPSSPI in isoform 2.		VSP_031514
	Alternative sequence	295 – 747	453	Missing in isoform 2.		VSP_031515

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 9D0EEF31702E9736	FASTA	747	79,929
	10 20 30 40 50 60 METAEKECGA LGGLFQAIVN DMKSSYPIWE DFNSKATKLH SQLRTTVLAA VAFLDAFQKV 70 80 90 100 110 120 ADMATNTRGA TRDIGSALTR MCMRHRSIET KLRQFTNALL ESLINPLQER IEDWKKAANQ 130 140 150 160 170 180 LDKDHAKEYK RARHEIKKKS SDTLKLQKKA RKELLGKGDL QPQLDSALQD VNDMYLLLEE 190 200 210 220 230 240 TEKQAVRRAL IEERGRFCTF ITFLQPVVNG ELTMLGEITH LQGIIDDLVV LTAEPHKLPP 250 260 270 280 290 300 ASEQVIKDLK GSDYSWSYQT PPSSPSSSSS RKSSMCSAPS SSSSAKGGGA PWPGGAQTYS 310 320 330 340 350 360 PSSTCRYRSL AQPATTTARL SSVSSHDSGF VSQDATYSKP PSPMPSDITS QKSSSSASSE 370 380 390 400 410 420 ASETCQSVSE CSSPTSDWSK VGSHEQPSGA TLQRRKDRVE LLRDTEPGPA SGGTLGPSGE 430 440 450 460 470 480 EAPRPRMSPA TIAAKHGEEV SPAASDLAMV LTRGLSLEHQ KSSRDSLQYS SGYSTQTTTP 490 500 510 520 530 540 SCSEDTIPSQ GSDYDCYSVN GDADSEGPPE FDKSSTIPRN SNIAQNYRRL IQTKRPASTA 550 560 570 580 590 600 GLPTAGLPTA TGLPSGAPPG VATIRRTPST KPTVRRALSS AGPIPIRPPI VPVKTPTVPD 610 620 630 640 650 660 SPGYMGPTRA GSEECVFYTD ETASPLAPDL AKASPKRLSL PNTAWGSPSP EAAGYPGAGA 670 680 690 700 710 720 EDEQQQLAAN RHSLVEKLGE LVAGAHALGE GQFPFPTALS ATPTEETPTP PPAATSDPPA 730 740 EDMLVAIRRG VRLRRTVTND RSAPRIL
	Isoform 2 [UniParc]. Checksum: CF46678FF8C4A83D	FASTA	291	32,799
	10 20 30 40 50 60 METAEKECGA LGGLFQAIVN DMKSSYPIWE DFNSKATKLH SQLRTTVLAA VAFLDAFQKV 70 80 90 100 110 120 ADMATNTRGA TRDIGSALTR MCMRHRSIET KLRQFTNALL ESLINPLQER IEDWKKAANQ 130 140 150 160 170 180 LDKDHAKEYK RARHEIKKKS SDTLKLQKKA RKGKGDLQPQ LDSALQDVND MYLLLEETEK 190 200 210 220 230 240 QAVRRALIEE RGRFCTFITF LQPVVNGELT MLGEITHLQG IIDDLVVLTA EPHKLPPASE 250 260 270 280 290 QVIKDLKGSD YSWSYQTPPS VPSEPFVSFL SVRFWKNSPL LPAPSTPSSP I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein." Yamagishi A., Masuda M., Ohki T., Onishi H., Mochizuki N. J. Biol. Chem. 279:14929-14936(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DOMAIN.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-747 (ISOFORM 2). Tissue: Skin.
[4]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601; SER-639 AND THR-643, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-441; SER-579; SER-612; SER-624; SER-634 AND SER-639, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-441, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB115770 mRNA. Translation: BAC98378.1. AC020763 Genomic DNA. No translation available. BC002770 mRNA. Translation: AAH02770.1.
IPI	IPI00783109. IPI00884952.
RefSeq	NP_612392.1. NM_138383.2.
UniGene	Hs.432387.
3D structure databases
ProteinModelPortal	Q765P7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q765P7. 1 interaction.
STRING	9606.ENSP00000341171.
PTM databases
PhosphoSite	Q765P7.
Polymorphism databases
DMDM	74727332.
Proteomic databases
PaxDb	Q765P7.
PRIDE	Q765P7.
Protocols and materials databases
DNASU	92154.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000338779; ENSP00000341171; ENSG00000132613.
GeneID	92154.
KEGG	hsa:92154.
UCSC	uc002ezj.3. human. uc002ezk.1. human.
Organism-specific databases
CTD	92154.
GeneCards	GC16M070695.
HGNC	HGNC:25094. MTSS1L.
HPA	HPA048531.
neXtProt	NX_Q765P7.
PharmGKB	PA164723215.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG72831.
HOGENOM	HOG000113691.
HOVERGEN	HBG052530.
InParanoid	Q765P7.
OMA	YVGPTRA.
OrthoDB	EOG4JHCFB.
Gene expression databases
Bgee	Q765P7.
Genevestigator	Q765P7.
Family and domain databases
InterPro	IPR013606. IRSp53/MIM_homology_IMD. [Graphical view]
Pfam	PF08397. IMD. 1 hit. [Graphical view]
PROSITE	PS51338. IMD. 1 hit. PS51082. WH2. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MTSS1L. human.
GenomeRNAi	92154.
NextBio	77613.

Entry information

Entry name

MTSSL_HUMAN

Accession

Primary (citable) accession number: Q765P7
Secondary accession number(s): A6NJI7, Q9BUA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.