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Protein

Urotensin-2B

Gene

Uts2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potent vasoconstrictor.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD
  • hormone activity Source: UniProtKB-KW

GO - Biological processi

  • regulation of blood pressure Source: RGD
  • regulation of blood vessel diameter Source: InterPro

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Urotensin-2B
Alternative name(s):
Urotensin II-related peptide
Urotensin IIB
Short name:
U-IIB
Short name:
UIIB
Urotensin-2 domain-containing protein
Gene namesi
Name:Uts2b
Synonyms:Urp, Uts2d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi727977. Uts2b.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
PropeptideiPRO_000003636128 – 108Add BLAST81
PeptideiPRO_0000036362111 – 118Urotensin-2B8

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi112 ↔ 117By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ765I2.
PRIDEiQ765I2.

Expressioni

Tissue specificityi

Expressed in a number of tissues includinf brain, thymus, spleen, testis and spinal cord.1 Publication

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD
  • hormone activity Source: UniProtKB-KW

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039320.

Family & Domainsi

Sequence similaritiesi

Belongs to the urotensin-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J14T. Eukaryota.
ENOG410XXYD. LUCA.
GeneTreeiENSGT00390000003511.
HOVERGENiHBG063072.
InParanoidiQ765I2.
KOiK05248.
OMAiNFDFQRP.
OrthoDBiEOG091G0VM1.
PhylomeDBiQ765I2.

Family and domain databases

InterProiView protein in InterPro
IPR001483. Urotensin_II.
PfamiView protein in Pfam
PF02083. Urotensin_II. 1 hit.
PROSITEiView protein in PROSITE
PS00984. UROTENSIN_II. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q765I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFSTSLCF GLLALLSVTT LLHSVRGRPH LSSGHELFPA EEHTTQEKLP
60 70 80 90 100
LGLLIRNPGF QRPAHAGVDL PSKVEELRQL KKLREWFMEA KSAEPSNALD
110
KLSSSHPIKR ACFWKYCV
Length:118
Mass (Da):13,341
Last modified:July 5, 2004 - v1
Checksum:i824DC58F9E9B3877
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116019 mRNA. Translation: BAC98927.1.
AY321314 mRNA. Translation: AAQ83884.1.
RefSeqiNP_937766.1. NM_198133.2.
UniGeneiRn.105611.

Genome annotation databases

EnsembliENSRNOT00000042650; ENSRNOP00000039320; ENSRNOG00000038512.
GeneIDi378939.
KEGGirno:378939.
UCSCiRGD:727977. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUTS2B_RAT
AccessioniPrimary (citable) accession number: Q765I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families