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Protein

Urotensin-2B

Gene

Uts2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potent vasoconstrictor.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD

GO - Biological processi

  • regulation of blood pressure Source: RGD
  • regulation of vasodilation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Urotensin-2B
Alternative name(s):
Urotensin II-related peptide
Urotensin IIB
Short name:
U-IIB
Short name:
UIIB
Urotensin-2 domain-containing protein
Gene namesi
Name:Uts2b
Synonyms:Urp, Uts2d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi727977. Uts2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Propeptidei28 – 10881PRO_0000036361Add
BLAST
Peptidei111 – 1188Urotensin-2BPRO_0000036362

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi112 ↔ 117By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ765I2.
PRIDEiQ765I2.

Expressioni

Tissue specificityi

Expressed in a number of tissues includinf brain, thymus, spleen, testis and spinal cord.1 Publication

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039320.

Family & Domainsi

Sequence similaritiesi

Belongs to the urotensin-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J14T. Eukaryota.
ENOG410XXYD. LUCA.
GeneTreeiENSGT00390000003511.
HOVERGENiHBG063072.
InParanoidiQ765I2.
KOiK05248.
OMAiHPNKRAC.
OrthoDBiEOG7B05FZ.
PhylomeDBiQ765I2.

Family and domain databases

InterProiIPR001483. Urotensin_II.
[Graphical view]
PfamiPF02083. Urotensin_II. 1 hit.
[Graphical view]
PROSITEiPS00984. UROTENSIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q765I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFSTSLCF GLLALLSVTT LLHSVRGRPH LSSGHELFPA EEHTTQEKLP
60 70 80 90 100
LGLLIRNPGF QRPAHAGVDL PSKVEELRQL KKLREWFMEA KSAEPSNALD
110
KLSSSHPIKR ACFWKYCV
Length:118
Mass (Da):13,341
Last modified:July 5, 2004 - v1
Checksum:i824DC58F9E9B3877
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116019 mRNA. Translation: BAC98927.1.
AY321314 mRNA. Translation: AAQ83884.1.
RefSeqiNP_937766.1. NM_198133.2.
UniGeneiRn.105611.

Genome annotation databases

EnsembliENSRNOT00000042650; ENSRNOP00000039320; ENSRNOG00000038512.
GeneIDi378939.
KEGGirno:378939.
UCSCiRGD:727977. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116019 mRNA. Translation: BAC98927.1.
AY321314 mRNA. Translation: AAQ83884.1.
RefSeqiNP_937766.1. NM_198133.2.
UniGeneiRn.105611.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039320.

Proteomic databases

PaxDbiQ765I2.
PRIDEiQ765I2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000042650; ENSRNOP00000039320; ENSRNOG00000038512.
GeneIDi378939.
KEGGirno:378939.
UCSCiRGD:727977. rat.

Organism-specific databases

CTDi257313.
RGDi727977. Uts2b.

Phylogenomic databases

eggNOGiENOG410J14T. Eukaryota.
ENOG410XXYD. LUCA.
GeneTreeiENSGT00390000003511.
HOVERGENiHBG063072.
InParanoidiQ765I2.
KOiK05248.
OMAiHPNKRAC.
OrthoDBiEOG7B05FZ.
PhylomeDBiQ765I2.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

NextBioi692435.
PROiQ765I2.

Family and domain databases

InterProiIPR001483. Urotensin_II.
[Graphical view]
PfamiPF02083. Urotensin_II. 1 hit.
[Graphical view]
PROSITEiPS00984. UROTENSIN_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain."
    Sugo T., Murakami Y., Shimomura Y., Harada M., Abe M., Ishibashi Y., Kitada C., Miyajima N., Suzuki N., Mori M., Fujino M.
    Biochem. Biophys. Res. Commun. 310:860-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 111-118, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Characterization of a novel urotensin II precursor: urotensin II B (U2B)."
    Nothacker H.-P., Civelli O.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiUTS2B_RAT
AccessioniPrimary (citable) accession number: Q765I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: November 11, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.