Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Urotensin-2B

Gene

UTS2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Potent vasoconstrictor.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Urotensin-2B
Alternative name(s):
Urotensin II-related peptide
Urotensin IIB
Short name:
U-IIB
Short name:
UIIB
Urotensin-2 domain-containing protein
Gene namesi
Name:UTS2B
Synonyms:URP, UTS2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30894. UTS2B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670632.

Polymorphism and mutation databases

BioMutaiUTS2B.
DMDMi212287929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Propeptidei29 – 10981By similarityPRO_0000036357Add
BLAST
Peptidei112 – 1198Urotensin-2BPRO_0000036358

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi113 ↔ 118By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ765I0.
PRIDEiQ765I0.

PTM databases

PhosphoSiteiQ765I0.

Expressioni

Gene expression databases

BgeeiENSG00000188958.
CleanExiHS_UTS2D.
ExpressionAtlasiQ765I0. baseline and differential.
GenevisibleiQ765I0. HS.

Organism-specific databases

HPAiHPA026992.

Interactioni

Protein-protein interaction databases

BioGridi129211. 1 interaction.
STRINGi9606.ENSP00000340526.

Structurei

3D structure databases

ProteinModelPortaliQ765I0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urotensin-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J14T. Eukaryota.
ENOG410XXYD. LUCA.
GeneTreeiENSGT00390000003511.
HOGENOMiHOG000133099.
HOVERGENiHBG063072.
InParanoidiQ765I0.
OrthoDBiEOG091G0VM1.
PhylomeDBiQ765I0.
TreeFamiTF338338.

Family and domain databases

InterProiIPR001483. Urotensin_II.
[Graphical view]
PfamiPF02083. Urotensin_II. 1 hit.
[Graphical view]
PROSITEiPS00984. UROTENSIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q765I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKILSSTVC FGLLTLLSVL SFLQSVHGRP YLTQGNEIFP DKKYTNREEL
60 70 80 90 100
LLALLNKNFD FQRPFNTDLA LPNKLEELNQ LEKLKEQLVE EKDSETSYAV
110
DGLFSSHPSK RACFWKYCV
Length:119
Mass (Da):13,749
Last modified:July 22, 2008 - v2
Checksum:i389E27F6469DA596
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211S → I.3 Publications
Corresponds to variant rs6788319 [ dbSNP | Ensembl ].
VAR_044517

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116021 mRNA. Translation: BAC98929.1.
AY321313 mRNA. Translation: AAQ83883.1.
AK090630 mRNA. Translation: BAG52200.1.
CH471052 Genomic DNA. Translation: EAW78091.1.
CH471052 Genomic DNA. Translation: EAW78092.1.
CH471052 Genomic DNA. Translation: EAW78093.1.
CH471052 Genomic DNA. Translation: EAW78094.1.
BC112166 mRNA. Translation: AAI12167.1.
CCDSiCCDS3300.1.
RefSeqiNP_937795.2. NM_198152.3.
XP_011510933.1. XM_011512631.1.
UniGeneiHs.518492.

Genome annotation databases

EnsembliENST00000340524; ENSP00000340526; ENSG00000188958.
ENST00000427544; ENSP00000398761; ENSG00000188958.
GeneIDi257313.
KEGGihsa:257313.
UCSCiuc003fsu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116021 mRNA. Translation: BAC98929.1.
AY321313 mRNA. Translation: AAQ83883.1.
AK090630 mRNA. Translation: BAG52200.1.
CH471052 Genomic DNA. Translation: EAW78091.1.
CH471052 Genomic DNA. Translation: EAW78092.1.
CH471052 Genomic DNA. Translation: EAW78093.1.
CH471052 Genomic DNA. Translation: EAW78094.1.
BC112166 mRNA. Translation: AAI12167.1.
CCDSiCCDS3300.1.
RefSeqiNP_937795.2. NM_198152.3.
XP_011510933.1. XM_011512631.1.
UniGeneiHs.518492.

3D structure databases

ProteinModelPortaliQ765I0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129211. 1 interaction.
STRINGi9606.ENSP00000340526.

PTM databases

PhosphoSiteiQ765I0.

Polymorphism and mutation databases

BioMutaiUTS2B.
DMDMi212287929.

Proteomic databases

PaxDbiQ765I0.
PRIDEiQ765I0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340524; ENSP00000340526; ENSG00000188958.
ENST00000427544; ENSP00000398761; ENSG00000188958.
GeneIDi257313.
KEGGihsa:257313.
UCSCiuc003fsu.4. human.

Organism-specific databases

CTDi257313.
GeneCardsiUTS2B.
H-InvDBHIX0017782.
HGNCiHGNC:30894. UTS2B.
HPAiHPA026992.
neXtProtiNX_Q765I0.
PharmGKBiPA142670632.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J14T. Eukaryota.
ENOG410XXYD. LUCA.
GeneTreeiENSGT00390000003511.
HOGENOMiHOG000133099.
HOVERGENiHBG063072.
InParanoidiQ765I0.
OrthoDBiEOG091G0VM1.
PhylomeDBiQ765I0.
TreeFamiTF338338.

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.

Miscellaneous databases

GenomeRNAii257313.
PROiQ765I0.

Gene expression databases

BgeeiENSG00000188958.
CleanExiHS_UTS2D.
ExpressionAtlasiQ765I0. baseline and differential.
GenevisibleiQ765I0. HS.

Family and domain databases

InterProiIPR001483. Urotensin_II.
[Graphical view]
PfamiPF02083. Urotensin_II. 1 hit.
[Graphical view]
PROSITEiPS00984. UROTENSIN_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUTS2B_HUMAN
AccessioniPrimary (citable) accession number: Q765I0
Secondary accession number(s): B3KQY8, D3DNW1, Q2M1Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 22, 2008
Last modified: September 7, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.