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Q765A7

- PGAP1_RAT

UniProt

Q765A7 - PGAP1_RAT

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Protein

GPI inositol-deacylase

Gene
Pgap1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei174 – 1741

GO - Molecular functioni

  1. nuclease activity Source: UniProtKB
  2. phosphoric ester hydrolase activity Source: UniProtKB

GO - Biological processi

  1. anterior/posterior axis specification Source: Ensembl
  2. embryonic pattern specification Source: Ensembl
  3. forebrain regionalization Source: Ensembl
  4. GPI anchor biosynthetic process Source: RGD
  5. head development Source: Ensembl
  6. intracellular protein transport Source: InterPro
  7. myo-inositol transport Source: UniProtKB
  8. nucleic acid phosphodiester bond hydrolysis Source: GOC
  9. sensory perception of sound Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
GPI inositol-deacylase (EC:3.1.-.-)
Alternative name(s):
Post-GPI attachment to proteins factor 1
Gene namesi
Name:Pgap1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1303213. Pgap1.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei12 – 3221Helical; Reviewed predictionAdd
BLAST
Topological domaini33 – 597565Lumenal Reviewed predictionAdd
BLAST
Transmembranei598 – 61821Helical; Reviewed predictionAdd
BLAST
Topological domaini619 – 64123Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei642 – 66221Helical; Reviewed predictionAdd
BLAST
Topological domaini663 – 6686Lumenal Reviewed prediction
Transmembranei669 – 68921Helical; Reviewed predictionAdd
BLAST
Topological domaini690 – 6945Cytoplasmic Reviewed prediction
Transmembranei695 – 71521Helical; Reviewed predictionAdd
BLAST
Topological domaini716 – 73318Lumenal Reviewed predictionAdd
BLAST
Transmembranei734 – 75421Helical; Reviewed predictionAdd
BLAST
Topological domaini755 – 81662Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei817 – 83721Helical; Reviewed predictionAdd
BLAST
Topological domaini838 – 85316Lumenal Reviewed predictionAdd
BLAST
Transmembranei854 – 87421Helical; Reviewed predictionAdd
BLAST
Topological domaini875 – 89420Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei895 – 91521Helical; Reviewed predictionAdd
BLAST
Topological domaini916 – 9227Lumenal Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi174 – 1741S → A: Abolishes the inositol deacylation of GPI-anchor proteins. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 922922GPI inositol-deacylasePRO_0000277625Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi363 – 3631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi402 – 4021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi558 – 5581N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ765A7.
PRIDEiQ765A7.

Expressioni

Gene expression databases

GenevestigatoriQ765A7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017967.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG312611.
GeneTreeiENSGT00390000016484.
HOGENOMiHOG000090006.
HOVERGENiHBG082122.
InParanoidiQ765A7.
KOiK05294.
OMAiTKFVHEC.
OrthoDBiEOG7KM5RZ.
PhylomeDBiQ765A7.
TreeFamiTF314565.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR012908. PGAP1-like.
[Graphical view]
PfamiPF07819. PGAP1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q765A7-1 [UniParc]FASTAAdd to Basket

« Hide

MFLHSVNLWN LAFYVFMVFL ATLGLWDVFF GFEENKCSMS YMFEYPEYQK    50
IELPKKLTKR YPAYELYLYG EGSYAEEHKI LPLTGIPVLF LPGNAGSYKQ 100
VRSIGSIALR KAEDIDFKYH FDFFSVNFNE ELVALYGGSL QKQTKFVHEC 150
IKAILKLYKG QEFPPTSVAI IGHSMGGLVA RALLTLKNFK QDLINLLVTQ 200
ATPHVAPVMP LDRFITEFYM TVNNYWILNA RHINLTTLSV AGGFRDYQVR 250
SGLTFLPTLS HHTSALSVVT SAVPKTWVST DHLSIVWCKQ LQLTTIRAFF 300
DLIDADTKQI TQKSKKKLSV LNHHFIRHPA KQFEENPSII SDLTGTSMWV 350
PVKVSRWSYV AYNESDKIYF AFPLANHRKV YTHAYCQSTM LDTNSWIFGC 400
INSTSMCRQG VDLSWKAELL PTIKSLTLRL QDYPSLSHIV VYVPSVHGSK 450
FVVDCEFFKK EARSIQLPVT HLFSFGLSSR KAIINTSGRY YNIELLNLGQ 500
IYQAFKVNVV SKCTGGKEEI TSIYKLHIPW SYEDSLTIAQ VPSSVDISLK 550
LHVAQPENDS HVALLKMYTS SDCQYEVTIK TSFPQILGQV VRFHGGALPA 600
YVVSSILLAY GGQLYSLLST GFCLEYGTML DKEAKPYKVD PFVIMIKFLL 650
GYKWFKELWD AVLLPELDAI VLTSQSMCFP LVSLILFLFG TCTAYWSGLL 700
SSASVQLLSS LWLALKRPAE LPKDVKVMSP DLPVLTVVFL IISWTTCGAL 750
AILLSYLYYV FKVVHLQASL TTFKNNQPVN PKHSRRSEKK SNHHKDSAIQ 800
NPRLSANDAE DSLRMHSTVI NLLTWVVLLS MPSLIYWSKN LRYYFKLNPD 850
PCKPLAFLLI PAIAVLGNTH TVSIKSSKLL KTASQFPLPL AVGVIAFGSS 900
HLYRVPCFVI IPLVFHSLCN FM 922
Length:922
Mass (Da):104,384
Last modified:July 5, 2004 - v1
Checksum:iB07E02DF99875FD3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB116149 mRNA. Translation: BAD08353.1.
RefSeqiNP_973719.1. NM_201990.1.
UniGeneiRn.205923.

Genome annotation databases

EnsembliENSRNOT00000017967; ENSRNOP00000017967; ENSRNOG00000013388.
GeneIDi316400.
KEGGirno:316400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB116149 mRNA. Translation: BAD08353.1 .
RefSeqi NP_973719.1. NM_201990.1.
UniGenei Rn.205923.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000017967.

Proteomic databases

PaxDbi Q765A7.
PRIDEi Q765A7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000017967 ; ENSRNOP00000017967 ; ENSRNOG00000013388 .
GeneIDi 316400.
KEGGi rno:316400.

Organism-specific databases

CTDi 80055.
RGDi 1303213. Pgap1.

Phylogenomic databases

eggNOGi NOG312611.
GeneTreei ENSGT00390000016484.
HOGENOMi HOG000090006.
HOVERGENi HBG082122.
InParanoidi Q765A7.
KOi K05294.
OMAi TKFVHEC.
OrthoDBi EOG7KM5RZ.
PhylomeDBi Q765A7.
TreeFami TF314565.

Miscellaneous databases

NextBioi 670811.
PROi Q765A7.

Gene expression databases

Genevestigatori Q765A7.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR012908. PGAP1-like.
[Graphical view ]
Pfami PF07819. PGAP1. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00120. LIPASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p."
    Tanaka S., Maeda Y., Tashima Y., Kinoshita T.
    J. Biol. Chem. 279:14256-14263(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, MUTAGENESIS OF SER-174.

Entry informationi

Entry nameiPGAP1_RAT
AccessioniPrimary (citable) accession number: Q765A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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