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Q765A7

- PGAP1_RAT

UniProt

Q765A7 - PGAP1_RAT

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Protein

GPI inositol-deacylase

Gene

Pgap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei174 – 1741

GO - Molecular functioni

  1. nuclease activity Source: UniProtKB
  2. phosphoric ester hydrolase activity Source: UniProtKB

GO - Biological processi

  1. anterior/posterior axis specification Source: Ensembl
  2. embryonic pattern specification Source: Ensembl
  3. forebrain regionalization Source: Ensembl
  4. GPI anchor biosynthetic process Source: RGD
  5. head development Source: Ensembl
  6. intracellular protein transport Source: InterPro
  7. myo-inositol transport Source: UniProtKB
  8. nucleic acid phosphodiester bond hydrolysis Source: GOC
  9. sensory perception of sound Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
GPI inositol-deacylase (EC:3.1.-.-)
Alternative name(s):
Post-GPI attachment to proteins factor 1
Gene namesi
Name:Pgap1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1303213. Pgap1.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi174 – 1741S → A: Abolishes the inositol deacylation of GPI-anchor proteins. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 922922GPI inositol-deacylasePRO_0000277625Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi558 – 5581N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ765A7.
PRIDEiQ765A7.

Expressioni

Gene expression databases

GenevestigatoriQ765A7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017967.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini33 – 597565LumenalSequence AnalysisAdd
BLAST
Topological domaini619 – 64123CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini663 – 6686LumenalSequence Analysis
Topological domaini690 – 6945CytoplasmicSequence Analysis
Topological domaini716 – 73318LumenalSequence AnalysisAdd
BLAST
Topological domaini755 – 81662CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini838 – 85316LumenalSequence AnalysisAdd
BLAST
Topological domaini875 – 89420CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini916 – 9227LumenalSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Transmembranei598 – 61821HelicalSequence AnalysisAdd
BLAST
Transmembranei642 – 66221HelicalSequence AnalysisAdd
BLAST
Transmembranei669 – 68921HelicalSequence AnalysisAdd
BLAST
Transmembranei695 – 71521HelicalSequence AnalysisAdd
BLAST
Transmembranei734 – 75421HelicalSequence AnalysisAdd
BLAST
Transmembranei817 – 83721HelicalSequence AnalysisAdd
BLAST
Transmembranei854 – 87421HelicalSequence AnalysisAdd
BLAST
Transmembranei895 – 91521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI inositol-deacylase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG312611.
GeneTreeiENSGT00390000016484.
HOGENOMiHOG000090006.
HOVERGENiHBG082122.
InParanoidiQ765A7.
KOiK05294.
OMAiTKFVHEC.
OrthoDBiEOG7KM5RZ.
PhylomeDBiQ765A7.
TreeFamiTF314565.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR012908. PGAP1-like.
[Graphical view]
PfamiPF07819. PGAP1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q765A7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLHSVNLWN LAFYVFMVFL ATLGLWDVFF GFEENKCSMS YMFEYPEYQK
60 70 80 90 100
IELPKKLTKR YPAYELYLYG EGSYAEEHKI LPLTGIPVLF LPGNAGSYKQ
110 120 130 140 150
VRSIGSIALR KAEDIDFKYH FDFFSVNFNE ELVALYGGSL QKQTKFVHEC
160 170 180 190 200
IKAILKLYKG QEFPPTSVAI IGHSMGGLVA RALLTLKNFK QDLINLLVTQ
210 220 230 240 250
ATPHVAPVMP LDRFITEFYM TVNNYWILNA RHINLTTLSV AGGFRDYQVR
260 270 280 290 300
SGLTFLPTLS HHTSALSVVT SAVPKTWVST DHLSIVWCKQ LQLTTIRAFF
310 320 330 340 350
DLIDADTKQI TQKSKKKLSV LNHHFIRHPA KQFEENPSII SDLTGTSMWV
360 370 380 390 400
PVKVSRWSYV AYNESDKIYF AFPLANHRKV YTHAYCQSTM LDTNSWIFGC
410 420 430 440 450
INSTSMCRQG VDLSWKAELL PTIKSLTLRL QDYPSLSHIV VYVPSVHGSK
460 470 480 490 500
FVVDCEFFKK EARSIQLPVT HLFSFGLSSR KAIINTSGRY YNIELLNLGQ
510 520 530 540 550
IYQAFKVNVV SKCTGGKEEI TSIYKLHIPW SYEDSLTIAQ VPSSVDISLK
560 570 580 590 600
LHVAQPENDS HVALLKMYTS SDCQYEVTIK TSFPQILGQV VRFHGGALPA
610 620 630 640 650
YVVSSILLAY GGQLYSLLST GFCLEYGTML DKEAKPYKVD PFVIMIKFLL
660 670 680 690 700
GYKWFKELWD AVLLPELDAI VLTSQSMCFP LVSLILFLFG TCTAYWSGLL
710 720 730 740 750
SSASVQLLSS LWLALKRPAE LPKDVKVMSP DLPVLTVVFL IISWTTCGAL
760 770 780 790 800
AILLSYLYYV FKVVHLQASL TTFKNNQPVN PKHSRRSEKK SNHHKDSAIQ
810 820 830 840 850
NPRLSANDAE DSLRMHSTVI NLLTWVVLLS MPSLIYWSKN LRYYFKLNPD
860 870 880 890 900
PCKPLAFLLI PAIAVLGNTH TVSIKSSKLL KTASQFPLPL AVGVIAFGSS
910 920
HLYRVPCFVI IPLVFHSLCN FM
Length:922
Mass (Da):104,384
Last modified:July 5, 2004 - v1
Checksum:iB07E02DF99875FD3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB116149 mRNA. Translation: BAD08353.1.
RefSeqiNP_973719.1. NM_201990.1.
UniGeneiRn.205923.

Genome annotation databases

EnsembliENSRNOT00000017967; ENSRNOP00000017967; ENSRNOG00000013388.
GeneIDi316400.
KEGGirno:316400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB116149 mRNA. Translation: BAD08353.1 .
RefSeqi NP_973719.1. NM_201990.1.
UniGenei Rn.205923.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000017967.

Proteomic databases

PaxDbi Q765A7.
PRIDEi Q765A7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000017967 ; ENSRNOP00000017967 ; ENSRNOG00000013388 .
GeneIDi 316400.
KEGGi rno:316400.

Organism-specific databases

CTDi 80055.
RGDi 1303213. Pgap1.

Phylogenomic databases

eggNOGi NOG312611.
GeneTreei ENSGT00390000016484.
HOGENOMi HOG000090006.
HOVERGENi HBG082122.
InParanoidi Q765A7.
KOi K05294.
OMAi TKFVHEC.
OrthoDBi EOG7KM5RZ.
PhylomeDBi Q765A7.
TreeFami TF314565.

Miscellaneous databases

NextBioi 670811.
PROi Q765A7.

Gene expression databases

Genevestigatori Q765A7.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR012908. PGAP1-like.
[Graphical view ]
Pfami PF07819. PGAP1. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00120. LIPASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p."
    Tanaka S., Maeda Y., Tashima Y., Kinoshita T.
    J. Biol. Chem. 279:14256-14263(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, MUTAGENESIS OF SER-174.

Entry informationi

Entry nameiPGAP1_RAT
AccessioniPrimary (citable) accession number: Q765A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3