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Protein

GPI inositol-deacylase

Gene

Pgap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1741

GO - Molecular functioni

  • nuclease activity Source: UniProtKB
  • phosphoric ester hydrolase activity Source: UniProtKB

GO - Biological processi

  • anterior/posterior axis specification Source: Ensembl
  • embryonic pattern specification Source: Ensembl
  • forebrain regionalization Source: Ensembl
  • GPI anchor biosynthetic process Source: RGD
  • myo-inositol transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • sensory perception of sound Source: Ensembl

Keywordsi

Molecular functionHydrolase
Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-162791 Attachment of GPI anchor to uPAR

Protein family/group databases

ESTHERiratno-q765a7 PGAP1

Names & Taxonomyi

Protein namesi
Recommended name:
GPI inositol-deacylase (EC:3.1.-.-)
Alternative name(s):
Post-GPI attachment to proteins factor 1
Gene namesi
Name:Pgap1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1303213 Pgap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 597LumenalSequence analysisAdd BLAST565
Transmembranei598 – 618HelicalSequence analysisAdd BLAST21
Topological domaini619 – 641CytoplasmicSequence analysisAdd BLAST23
Transmembranei642 – 662HelicalSequence analysisAdd BLAST21
Topological domaini663 – 668LumenalSequence analysis6
Transmembranei669 – 689HelicalSequence analysisAdd BLAST21
Topological domaini690 – 694CytoplasmicSequence analysis5
Transmembranei695 – 715HelicalSequence analysisAdd BLAST21
Topological domaini716 – 733LumenalSequence analysisAdd BLAST18
Transmembranei734 – 754HelicalSequence analysisAdd BLAST21
Topological domaini755 – 816CytoplasmicSequence analysisAdd BLAST62
Transmembranei817 – 837HelicalSequence analysisAdd BLAST21
Topological domaini838 – 853LumenalSequence analysisAdd BLAST16
Transmembranei854 – 874HelicalSequence analysisAdd BLAST21
Topological domaini875 – 894CytoplasmicSequence analysisAdd BLAST20
Transmembranei895 – 915HelicalSequence analysisAdd BLAST21
Topological domaini916 – 922LumenalSequence analysis7

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi174S → A: Abolishes the inositol deacylation of GPI-anchor proteins. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002776251 – 922GPI inositol-deacylaseAdd BLAST922

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi558N-linked (GlcNAc...) asparagine; alternateSequence analysis1
Glycosylationi558N-linked (HexNAc...) asparagine; alternateCombined sources1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ765A7
PRIDEiQ765A7

PTM databases

SwissPalmiQ765A7
UniCarbKBiQ765A7

Expressioni

Gene expression databases

BgeeiENSRNOG00000013388

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017967

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI inositol-deacylase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3724 Eukaryota
ENOG410YD9N LUCA
GeneTreeiENSGT00390000016484
HOGENOMiHOG000090006
HOVERGENiHBG082122
InParanoidiQ765A7
KOiK05294
OMAiTKFVHEC
OrthoDBiEOG091G06G8
PhylomeDBiQ765A7
TreeFamiTF314565

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR012908 PGAP1-like
PfamiView protein in Pfam
PF07819 PGAP1, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q765A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLHSVNLWN LAFYVFMVFL ATLGLWDVFF GFEENKCSMS YMFEYPEYQK
60 70 80 90 100
IELPKKLTKR YPAYELYLYG EGSYAEEHKI LPLTGIPVLF LPGNAGSYKQ
110 120 130 140 150
VRSIGSIALR KAEDIDFKYH FDFFSVNFNE ELVALYGGSL QKQTKFVHEC
160 170 180 190 200
IKAILKLYKG QEFPPTSVAI IGHSMGGLVA RALLTLKNFK QDLINLLVTQ
210 220 230 240 250
ATPHVAPVMP LDRFITEFYM TVNNYWILNA RHINLTTLSV AGGFRDYQVR
260 270 280 290 300
SGLTFLPTLS HHTSALSVVT SAVPKTWVST DHLSIVWCKQ LQLTTIRAFF
310 320 330 340 350
DLIDADTKQI TQKSKKKLSV LNHHFIRHPA KQFEENPSII SDLTGTSMWV
360 370 380 390 400
PVKVSRWSYV AYNESDKIYF AFPLANHRKV YTHAYCQSTM LDTNSWIFGC
410 420 430 440 450
INSTSMCRQG VDLSWKAELL PTIKSLTLRL QDYPSLSHIV VYVPSVHGSK
460 470 480 490 500
FVVDCEFFKK EARSIQLPVT HLFSFGLSSR KAIINTSGRY YNIELLNLGQ
510 520 530 540 550
IYQAFKVNVV SKCTGGKEEI TSIYKLHIPW SYEDSLTIAQ VPSSVDISLK
560 570 580 590 600
LHVAQPENDS HVALLKMYTS SDCQYEVTIK TSFPQILGQV VRFHGGALPA
610 620 630 640 650
YVVSSILLAY GGQLYSLLST GFCLEYGTML DKEAKPYKVD PFVIMIKFLL
660 670 680 690 700
GYKWFKELWD AVLLPELDAI VLTSQSMCFP LVSLILFLFG TCTAYWSGLL
710 720 730 740 750
SSASVQLLSS LWLALKRPAE LPKDVKVMSP DLPVLTVVFL IISWTTCGAL
760 770 780 790 800
AILLSYLYYV FKVVHLQASL TTFKNNQPVN PKHSRRSEKK SNHHKDSAIQ
810 820 830 840 850
NPRLSANDAE DSLRMHSTVI NLLTWVVLLS MPSLIYWSKN LRYYFKLNPD
860 870 880 890 900
PCKPLAFLLI PAIAVLGNTH TVSIKSSKLL KTASQFPLPL AVGVIAFGSS
910 920
HLYRVPCFVI IPLVFHSLCN FM
Length:922
Mass (Da):104,384
Last modified:July 5, 2004 - v1
Checksum:iB07E02DF99875FD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB116149 mRNA Translation: BAD08353.1
RefSeqiNP_973719.1, NM_201990.1
UniGeneiRn.205923

Genome annotation databases

EnsembliENSRNOT00000017967; ENSRNOP00000017967; ENSRNOG00000013388
GeneIDi316400
KEGGirno:316400

Similar proteinsi

Entry informationi

Entry nameiPGAP1_RAT
AccessioniPrimary (citable) accession number: Q765A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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