Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q764S1 (ACDH_BACPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Name:nahO
OrganismBacillus sp. (strain JF8)
Taxonomic identifier209076 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387625

Regions

Nucleotide binding12 – 154NAD By similarity
Nucleotide binding158 – 1669NAD By similarity

Sites

Active site1271Acyl-thioester intermediate By similarity
Binding site2761NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q764S1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: DB9686FCD895A115

FASTA30232,513
        10         20         30         40         50         60 
MNRTVKVAIL GSGNIGTDLM YKILKKRWVL ELSMIAGIDP QSEGLARARA EGVYATAGGI 

        70         80         90        100        110        120 
DAILEDPEIK IVFDATSAKA HLKHAKRLKE AGKVAIDLTP AAVGPYVVPP VNLMEHVDKD 

       130        140        150        160        170        180 
NVNLITCGGQ ATIPLVYAVS RVANVKYAEM VSTVSSSSAG PGTRQNIDEF TFTTSRGLEV 

       190        200        210        220        230        240 
IGGAEKGKAI IILNPAKPPI LMRNTVYIAY EDGDDHQIRH SIGQMIHDVQ QYVPGYRLKG 

       250        260        270        280        290        300 
EPIFDRRETP KGRLDVVILL LEVEGAGDFL PVSAGNLDIM TASAKQVGEV IAKRLIEMTS 


TA 

« Hide

References

[1]"Genes for Mn(II)-dependent NahC and Fe(II)-dependent NahH located in close proximity in the thermophilic naphthalene and PCB degrader, Bacillus sp. JF8: cloning and characterization."
Miyazawa D., Mukerjee-Dhar G., Shimura M., Hatta T., Kimbara K.
Microbiology 150:993-1004(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB116258 Genomic DNA. Translation: BAD08310.1.

3D structure databases

ProteinModelPortalQ764S1.
SMRQ764S1. Positions 1-297.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_BACPJ
AccessionPrimary (citable) accession number: Q764S1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families