ID   Q76353_9HIV1            Unreviewed;       288 AA.
AC   Q76353;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 159.
DE   SubName: Full=Integrase {ECO:0000313|EMBL:AAC37875.1};
DE   Flags: Fragment;
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AAC37875.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAC37875.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NY5 {ECO:0000313|EMBL:AAC37875.1};
RX   PubMed=7916726; DOI=10.1016/0378-1119(93)90488-O;
RA   Holler T.P., Foltin S.K., Ye Q.Z., Hupe D.J.;
RT   "HIV1 integrase expressed in Escherichia coli from a synthetic gene.";
RL   Gene 136:323-328(1993).
RN   [2] {ECO:0007829|PDB:6L0C}
RP   X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 50-212.
RX   PubMed=32611758; DOI=10.1128/jvi.00486-20;
RA   Nakamura T., Nakamura T., Amano M., Miyakawa T., Yamagata Y., Matsuoka M.,
RA   Nakata H.;
RT   "A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase
RT   Inhibitor. .";
RL   J. Virol. 94:e00486-e00420(2020).
CC   -!- INTERACTION:
CC       Q76353; Q7Z4H3: HDDC2; Xeno; NbExp=2; IntAct=EBI-6248077, EBI-6163836;
CC       Q76353; Q9H583: HEATR1; Xeno; NbExp=3; IntAct=EBI-6248077, EBI-1048716;
CC       Q76353; Q14566: MCM6; Xeno; NbExp=2; IntAct=EBI-6248077, EBI-374900;
CC       Q76353; P13667: PDIA4; Xeno; NbExp=3; IntAct=EBI-6248077, EBI-1054653;
CC       Q76353; Q9Y263: PLAA; Xeno; NbExp=3; IntAct=EBI-6248077, EBI-1994037;
CC       Q76353; O60518: RANBP6; Xeno; NbExp=2; IntAct=EBI-6248077, EBI-1055771;
CC       Q76353; P22314: UBA1; Xeno; NbExp=2; IntAct=EBI-6248077, EBI-709688;
CC       Q76353; P31946: YWHAB; Xeno; NbExp=3; IntAct=EBI-6248077, EBI-359815;
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DR   EMBL; L21188; AAC37875.1; -; Unassigned_RNA.
DR   PDB; 6L0C; X-ray; 2.10 A; A=50-212.
DR   PDBsum; 6PUT; -.
DR   PDBsum; 6PUW; -.
DR   PDBsum; 6PUY; -.
DR   PDBsum; 6PUZ; -.
DR   PDBsum; 6U8Q; -.
DR   PDBsum; 6UM8; -.
DR   PDBsum; 6V3K; -.
DR   SMR; Q76353; -.
DR   IntAct; Q76353; 25.
DR   BindingDB; Q76353; -.
DR   DrugCentral; Q76353; -.
DR   EvolutionaryTrace; Q76353; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.200; -; 1.
DR   Gene3D; 2.30.30.10; Integrase, C-terminal domain superfamily, retroviral; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR017856; Integrase-like_N.
DR   InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
DR   InterPro; IPR001037; Integrase_C_retrovir.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR   Pfam; PF00552; IN_DBD_C; 1.
DR   Pfam; PF02022; Integrase_Zn; 1.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF50122; DNA-binding domain of retroviral integrase; 1.
DR   SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS51027; INTEGRASE_DBD; 1.
DR   PROSITE; PS50876; ZF_INTEGRASE; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:6L0C};
KW   DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00450}.
FT   DOMAIN          3..44
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50876"
FT   DOMAIN          54..204
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   DOMAIN          223..270
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51027"
FT   DNA_BIND        223..270
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00506"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAC37875.1"
SQ   SEQUENCE   288 AA;  32199 MW;  0680E5CD1E201580 CRC64;
     FLDGIDKAQE EHEKYHSNWR AMASDFNLPP VVAKEIVASC DKCQLKGEAM HGQVDCSPGI
     WQLDCTHLEG KVILVAVHVA SGYIEAEVIP AETGQETAYF LLKLAGRWPV KTVHTDNGSN
     FTSTTVKAAC WWAGIKQEFG IPYNPQSQGV IESMNKELKK IIGQVRDQAE HLKTAVQMAV
     FIHNFKRKGG IGGYSAGERI VDIIATDIQT KELQKQITKI QNFRVYYRDS RDPVWKGPAK
     LLWKGEGAVV IQDNSDIKVV PRRKAKIIRD YGKQMAGDDC VASRQDED
//