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Q76353

- Q76353_9HIV1

UniProt

Q76353 - Q76353_9HIV1

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Protein
Submitted name:

Integrase

Gene
N/A
Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651Chloride 1; via amide nitrogenImported
Binding sitei67 – 671Acetate 1Imported
Binding sitei67 – 671Sulfate 2Imported
Binding sitei71 – 711Sulfate 3Imported
Binding sitei87 – 871Acetate 1Imported
Binding sitei87 – 871Acetate 7Imported
Binding sitei87 – 871Acetate 8Imported
Binding sitei87 – 871Acetate 9
Binding sitei87 – 871Sulfate 6Imported
Binding sitei92 – 921Acetate 1; via amide nitrogenImported
Binding sitei92 – 921Chloride 2; via amide nitrogenImported
Binding sitei92 – 921Chloride 3; via amide nitrogenImported
Binding sitei92 – 921Sulfate 2; via amide nitrogenImported
Binding sitei95 – 951Acetate 10; via amide nitrogenImported
Binding sitei95 – 951Sulfate 3Imported
Binding sitei95 – 951Sulfate 7Imported
Binding sitei99 – 991Acetate 11Imported
Binding sitei99 – 991Acetate 12Imported
Binding sitei99 – 991Acetate 8Imported
Binding sitei99 – 991Sulfate 9Imported
Binding sitei103 – 1031Acetate 11Imported
Binding sitei103 – 1031Acetate 12Imported
Binding sitei103 – 1031Acetate 8Imported
Binding sitei103 – 1031Sulfate 6Imported
Binding sitei103 – 1031Sulfate 9Imported
Binding sitei107 – 1071Acetate 12Imported
Binding sitei107 – 1071Acetate 13; via carbonyl oxygenImported
Binding sitei107 – 1071Acetate 17Imported
Binding sitei107 – 1071Acetate 4Imported
Binding sitei107 – 1071Acetate 6Imported
Binding sitei107 – 1071Sulfate 12Imported
Binding sitei107 – 1071Sulfate 3Imported
Binding sitei107 – 1071Sulfate 5Imported
Binding sitei107 – 1071Sulfate 7Imported
Binding sitei107 – 1071Sulfate 8Imported
Binding sitei125 – 1251Acetate 10Imported
Binding sitei159 – 1591Sulfate 1Imported
Binding sitei166 – 1661Sulfate 3Imported
Binding sitei172 – 1721Sulfate 15; via amide nitrogenImported
Binding sitei184 – 1841Acetate 15; via carbonyl oxygenImported
Binding sitei184 – 1841Acetate 16; via carbonyl oxygenImported
Binding sitei184 – 1841Sulfate 4; via carbonyl oxygenImported
Binding sitei197 – 1971Acetate 2; via carbonyl oxygenImported

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. endonuclease activity Source: UniProtKB-KW
  3. RNA-directed DNA polymerase activity Source: UniProtKB-KW
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA integration Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseSAAS annotation, Hydrolase, Nuclease, Nucleotidyltransferase, RNA-directed DNA polymeraseSAAS annotation, Transferase

Keywords - Biological processi

DNA integrationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
IntegraseImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HDDC2Q7Z4H32EBI-6248077,EBI-6163836From a different organism.
HEATR1Q9H5833EBI-6248077,EBI-1048716From a different organism.
MCM6Q145662EBI-6248077,EBI-374900From a different organism.
PDIA4P136673EBI-6248077,EBI-1054653From a different organism.
PLAAQ9Y2633EBI-6248077,EBI-1994037From a different organism.
RANBP6O605182EBI-6248077,EBI-1055771From a different organism.
UBA1P223142EBI-6248077,EBI-709688From a different organism.
YWHABP319463EBI-6248077,EBI-359815From a different organism.

Protein-protein interaction databases

IntActiQ76353. 25 interactions.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HYVX-ray1.70A47-212[»]
1HYZX-ray2.30A47-212[»]
3ZCMX-ray1.80A/B56-212[»]
3ZSOX-ray1.75A/B56-212[»]
3ZSQX-ray1.70A/B56-212[»]
3ZSRX-ray1.70A/B56-212[»]
3ZSVX-ray1.75A/B56-212[»]
3ZSWX-ray1.80A/B56-212[»]
3ZSXX-ray1.95A/B56-212[»]
3ZSYX-ray2.20A/B56-212[»]
3ZSZX-ray2.00A/B56-212[»]
3ZT0X-ray1.95A/B56-212[»]
3ZT1X-ray1.75A/B56-212[»]
3ZT2X-ray1.70A/B56-212[»]
3ZT3X-ray1.95A/B56-212[»]
3ZT4X-ray2.20A/B56-212[»]
4CE9X-ray2.10A/B50-212[»]
4CEAX-ray1.80A/B50-212[»]
4CEBX-ray1.75A/B50-212[»]
4CECX-ray1.75A/B50-212[»]
4CEDX-ray1.75A/B50-212[»]
4CEEX-ray1.80A/B50-212[»]
4CEFX-ray1.70A/B50-212[»]
4CEOX-ray1.90A/B50-212[»]
4CEQX-ray1.70A/B50-212[»]
4CERX-ray1.70A/B50-212[»]
4CESX-ray1.85A/B50-212[»]
4CEZX-ray1.70A/B50-212[»]
4CF0X-ray1.85A/B50-212[»]
4CF1X-ray1.95A/B50-212[»]
4CF2X-ray1.95A/B50-212[»]
4CF8X-ray1.65A/B50-212[»]
4CF9X-ray2.10A/B50-212[»]
4CFAX-ray2.05A/B50-212[»]
4CFBX-ray1.95A/B50-212[»]
4CFCX-ray1.90A/B50-212[»]
4CFDX-ray2.15A/B50-212[»]
4CGDX-ray2.00A/B50-212[»]
4CGFX-ray1.70A/B50-212[»]
4CGGX-ray1.75A/B50-212[»]
4CGHX-ray1.76A/B50-212[»]
4CGIX-ray2.07A/B50-212[»]
4CGJX-ray2.15A/B50-212[»]
4CHNX-ray2.00A/B50-212[»]
4CHOX-ray1.70A/B50-212[»]
4CHPX-ray1.90A/B50-212[»]
4CHQX-ray1.95A/B50-212[»]
4CHYX-ray1.70A/B50-212[»]
4CHZX-ray1.80A/B50-212[»]
4CIEX-ray1.70A/B50-212[»]
4CIFX-ray1.80A/B50-212[»]
4CIGX-ray1.70A/B50-212[»]
4CJ3X-ray1.70A/B50-212[»]
4CJ4X-ray1.80A/B50-212[»]
4CJ5X-ray1.95A/B50-212[»]
4CJEX-ray1.90A/B50-212[»]
4CJFX-ray1.90A/B50-212[»]
4CJKX-ray1.75A/B50-212[»]
4CJLX-ray1.77A50-212[»]
4CJPX-ray2.00A/B50-212[»]
4CJQX-ray1.70A/B50-212[»]
4CJRX-ray1.80A/B50-212[»]
4CJSX-ray1.80A/B50-212[»]
4CJTX-ray1.71A/B50-212[»]
4CJUX-ray1.70A/B50-212[»]
4CJVX-ray1.95A/B50-212[»]
4CJWX-ray1.95A/B50-212[»]
4CK1X-ray1.75A/B50-212[»]
4CK2X-ray1.85A/B50-212[»]
4CK3X-ray1.79A/B50-212[»]
4LH4X-ray1.80A50-212[»]
4LH5X-ray2.19A50-212[»]
4OVLX-ray1.70A/B50-212[»]
ProteinModelPortaliQ76353.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ76353.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 672Sulfate 1 bindingImported
Regioni85 – 873Acetate 4 bindingImported
Regioni85 – 873Acetate 5 bindingImported
Regioni85 – 873Acetate 6 bindingImported
Regioni85 – 873Sulfate 3 binding
Regioni85 – 873Sulfate 5 bindingImported
Regioni99 – 1035Acetate 4 bindingImported
Regioni100 – 1078Acetate 5 bindingImported
Regioni100 – 1034Acetate 6 bindingImported
Regioni100 – 1034Sulfate 3 binding
Regioni100 – 1034Sulfate 5 bindingImported
Regioni105 – 1095Sulfate 10 bindingImported
Regioni105 – 1084Sulfate 11 bindingImported
Regioni106 – 1094Acetate 15 bindingImported
Regioni106 – 1094Acetate 16 bindingImported
Regioni107 – 1093Acetate 2 bindingImported
Regioni123 – 1253Acetate 18 bindingImported
Regioni123 – 1253Sulfate 10 bindingImported
Regioni123 – 1253Sulfate 13 bindingImported
Regioni123 – 1253Sulfate 7 bindingImported
Regioni123 – 1253Sulfate 8 bindingImported
Regioni170 – 1745Sulfate 14 bindingImported
Regioni171 – 1744Chloride 5 bindingImported
Regioni171 – 1722Sulfate 3 bindingImported

Sequence similaritiesi

Contains RNase H domain.SAAS annotation
Contains integrase catalytic domain.SAAS annotation
Contains integrase-type DNA-binding domain.SAAS annotation
Contains integrase-type zinc finger.SAAS annotation
Contains reverse transcriptase domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Family and domain databases

Gene3Di1.10.10.200. 1 hit.
2.30.30.10. 1 hit.
3.30.420.10. 1 hit.
InterProiIPR001037. Integrase_C_retrovir.
IPR001584. Integrase_cat-core.
IPR017856. Integrase_Zn-bd_dom-like_N.
IPR003308. Integrase_Zn-bd_dom_N.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00552. IN_DBD_C. 1 hit.
PF02022. Integrase_Zn. 1 hit.
PF00665. rve. 1 hit.
[Graphical view]
SUPFAMiSSF46919. SSF46919. 1 hit.
SSF50122. SSF50122. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50994. INTEGRASE. 1 hit.
PS51027. INTEGRASE_DBD. 1 hit.
PS50876. ZF_INTEGRASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q76353 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
FLDGIDKAQE EHEKYHSNWR AMASDFNLPP VVAKEIVASC DKCQLKGEAM
60 70 80 90 100
HGQVDCSPGI WQLDCTHLEG KVILVAVHVA SGYIEAEVIP AETGQETAYF
110 120 130 140 150
LLKLAGRWPV KTVHTDNGSN FTSTTVKAAC WWAGIKQEFG IPYNPQSQGV
160 170 180 190 200
IESMNKELKK IIGQVRDQAE HLKTAVQMAV FIHNFKRKGG IGGYSAGERI
210 220 230 240 250
VDIIATDIQT KELQKQITKI QNFRVYYRDS RDPVWKGPAK LLWKGEGAVV
260 270 280
IQDNSDIKVV PRRKAKIIRD YGKQMAGDDC VASRQDED
Length:288
Mass (Da):32,199
Last modified:November 1, 1996 - v1
Checksum:i0680E5CD1E201580
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L21188 Unassigned RNA. Translation: AAC37875.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L21188 Unassigned RNA. Translation: AAC37875.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1HYV X-ray 1.70 A 47-212 [» ]
1HYZ X-ray 2.30 A 47-212 [» ]
3ZCM X-ray 1.80 A/B 56-212 [» ]
3ZSO X-ray 1.75 A/B 56-212 [» ]
3ZSQ X-ray 1.70 A/B 56-212 [» ]
3ZSR X-ray 1.70 A/B 56-212 [» ]
3ZSV X-ray 1.75 A/B 56-212 [» ]
3ZSW X-ray 1.80 A/B 56-212 [» ]
3ZSX X-ray 1.95 A/B 56-212 [» ]
3ZSY X-ray 2.20 A/B 56-212 [» ]
3ZSZ X-ray 2.00 A/B 56-212 [» ]
3ZT0 X-ray 1.95 A/B 56-212 [» ]
3ZT1 X-ray 1.75 A/B 56-212 [» ]
3ZT2 X-ray 1.70 A/B 56-212 [» ]
3ZT3 X-ray 1.95 A/B 56-212 [» ]
3ZT4 X-ray 2.20 A/B 56-212 [» ]
4CE9 X-ray 2.10 A/B 50-212 [» ]
4CEA X-ray 1.80 A/B 50-212 [» ]
4CEB X-ray 1.75 A/B 50-212 [» ]
4CEC X-ray 1.75 A/B 50-212 [» ]
4CED X-ray 1.75 A/B 50-212 [» ]
4CEE X-ray 1.80 A/B 50-212 [» ]
4CEF X-ray 1.70 A/B 50-212 [» ]
4CEO X-ray 1.90 A/B 50-212 [» ]
4CEQ X-ray 1.70 A/B 50-212 [» ]
4CER X-ray 1.70 A/B 50-212 [» ]
4CES X-ray 1.85 A/B 50-212 [» ]
4CEZ X-ray 1.70 A/B 50-212 [» ]
4CF0 X-ray 1.85 A/B 50-212 [» ]
4CF1 X-ray 1.95 A/B 50-212 [» ]
4CF2 X-ray 1.95 A/B 50-212 [» ]
4CF8 X-ray 1.65 A/B 50-212 [» ]
4CF9 X-ray 2.10 A/B 50-212 [» ]
4CFA X-ray 2.05 A/B 50-212 [» ]
4CFB X-ray 1.95 A/B 50-212 [» ]
4CFC X-ray 1.90 A/B 50-212 [» ]
4CFD X-ray 2.15 A/B 50-212 [» ]
4CGD X-ray 2.00 A/B 50-212 [» ]
4CGF X-ray 1.70 A/B 50-212 [» ]
4CGG X-ray 1.75 A/B 50-212 [» ]
4CGH X-ray 1.76 A/B 50-212 [» ]
4CGI X-ray 2.07 A/B 50-212 [» ]
4CGJ X-ray 2.15 A/B 50-212 [» ]
4CHN X-ray 2.00 A/B 50-212 [» ]
4CHO X-ray 1.70 A/B 50-212 [» ]
4CHP X-ray 1.90 A/B 50-212 [» ]
4CHQ X-ray 1.95 A/B 50-212 [» ]
4CHY X-ray 1.70 A/B 50-212 [» ]
4CHZ X-ray 1.80 A/B 50-212 [» ]
4CIE X-ray 1.70 A/B 50-212 [» ]
4CIF X-ray 1.80 A/B 50-212 [» ]
4CIG X-ray 1.70 A/B 50-212 [» ]
4CJ3 X-ray 1.70 A/B 50-212 [» ]
4CJ4 X-ray 1.80 A/B 50-212 [» ]
4CJ5 X-ray 1.95 A/B 50-212 [» ]
4CJE X-ray 1.90 A/B 50-212 [» ]
4CJF X-ray 1.90 A/B 50-212 [» ]
4CJK X-ray 1.75 A/B 50-212 [» ]
4CJL X-ray 1.77 A 50-212 [» ]
4CJP X-ray 2.00 A/B 50-212 [» ]
4CJQ X-ray 1.70 A/B 50-212 [» ]
4CJR X-ray 1.80 A/B 50-212 [» ]
4CJS X-ray 1.80 A/B 50-212 [» ]
4CJT X-ray 1.71 A/B 50-212 [» ]
4CJU X-ray 1.70 A/B 50-212 [» ]
4CJV X-ray 1.95 A/B 50-212 [» ]
4CJW X-ray 1.95 A/B 50-212 [» ]
4CK1 X-ray 1.75 A/B 50-212 [» ]
4CK2 X-ray 1.85 A/B 50-212 [» ]
4CK3 X-ray 1.79 A/B 50-212 [» ]
4LH4 X-ray 1.80 A 50-212 [» ]
4LH5 X-ray 2.19 A 50-212 [» ]
4OVL X-ray 1.70 A/B 50-212 [» ]
ProteinModelPortali Q76353.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q76353. 25 interactions.

Chemistry

ChEMBLi CHEMBL2366505.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q76353.

Family and domain databases

Gene3Di 1.10.10.200. 1 hit.
2.30.30.10. 1 hit.
3.30.420.10. 1 hit.
InterProi IPR001037. Integrase_C_retrovir.
IPR001584. Integrase_cat-core.
IPR017856. Integrase_Zn-bd_dom-like_N.
IPR003308. Integrase_Zn-bd_dom_N.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF00552. IN_DBD_C. 1 hit.
PF02022. Integrase_Zn. 1 hit.
PF00665. rve. 1 hit.
[Graphical view ]
SUPFAMi SSF46919. SSF46919. 1 hit.
SSF50122. SSF50122. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEi PS50994. INTEGRASE. 1 hit.
PS51027. INTEGRASE_DBD. 1 hit.
PS50876. ZF_INTEGRASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "HIV1 integrase expressed in Escherichia coli from a synthetic gene."
    Holler T.P., Foltin S.K., Ye Q.Z., Hupe D.J.
    Gene 136:323-328(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NY5Imported.
  2. "Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain."
    Molteni V., Greenwald J., Rhodes D., Hwang Y., Kwiatkowski W., Bushman F.D., Siegel J.S., Choe S.
    Acta Crystallogr. D 57:536-544(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 47-212.
  3. "Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design."
    Peat T.S., Rhodes D.I., Vandegraaff N., Le G., Smith J.A., Clark L.J., Jones E.D., Coates J.A., Thienthong N., Newman J., Dolezal O., Mulder R., Ryan J.H., Savage G.P., Francis C.L., Deadman J.J.
    PLoS ONE 7:e40147-e40147(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 56-212.
  4. "Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage."
    Le Rouzic E., Bonnard D., Chasset S., Bruneau J.M., Chevreuil F., Le Strat F., Nguyen J., Beauvoir R., Amadori C., Brias J., Vomscheid S., Eiler S., Levy N., Delelis O., Deprez E., Saib A., Zamborlini A., Emiliani S.
    , Ruff M., Ledoussal B., Moreau F., Benarous R.
    Retrovirology 10:144-144(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 50-212.
  5. "Interrogating HIV integrase for compounds that bind--a SAMPL challenge."
    Peat T.S., Dolezal O., Newman J., Mobley D., Deadman J.J.
    J. Comput. Aided Mol. Des. 28:347-362(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 50-212.

Entry informationi

Entry nameiQ76353_9HIV1
AccessioniPrimary (citable) accession number: Q76353
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3