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Protein
Submitted name:

Integrase

Gene
N/A
Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12Zinc; via tele nitrogenCombined sources1
Metal bindingi16Zinc; via pros nitrogenCombined sources1
Metal bindingi43ZincCombined sources1
Metal bindingi64MagnesiumCombined sources1
Metal bindingi116MagnesiumCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi223 – 270Integrase-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingSAAS annotation, EndonucleaseSAAS annotation, Hydrolase, Nuclease, Nucleotidyltransferase, RNA-directed DNA polymeraseSAAS annotation, Transferase
Biological processDNA integrationSAAS annotation
LigandMagnesiumCombined sources, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
IntegraseImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2366505.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ76353. 25 interactors.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HYVX-ray1.70A47-212[»]
1HYZX-ray2.30A47-212[»]
3LPTX-ray2.00A50-212[»]
3LPUX-ray1.95A50-212[»]
3ZCMX-ray1.80A/B56-212[»]
3ZSOX-ray1.75A/B56-212[»]
3ZSQX-ray1.70A/B56-212[»]
3ZSRX-ray1.70A/B56-212[»]
3ZSVX-ray1.75A/B56-212[»]
3ZSWX-ray1.80A/B56-212[»]
3ZSXX-ray1.95A/B56-212[»]
3ZSYX-ray2.20A/B56-212[»]
3ZSZX-ray2.00A/B56-212[»]
3ZT0X-ray1.95A/B56-212[»]
3ZT1X-ray1.75A/B56-212[»]
3ZT2X-ray1.70A/B56-212[»]
3ZT3X-ray1.95A/B56-212[»]
3ZT4X-ray2.20A/B56-212[»]
4CE9X-ray2.10A/B50-212[»]
4CEAX-ray1.80A/B50-212[»]
4CEBX-ray1.75A/B50-212[»]
4CECX-ray1.75A/B50-212[»]
4CEDX-ray1.75A/B50-212[»]
4CEEX-ray1.80A/B50-212[»]
4CEFX-ray1.70A/B50-212[»]
4CEOX-ray1.90A/B50-212[»]
4CEQX-ray1.70A/B50-212[»]
4CERX-ray1.70A/B50-212[»]
4CESX-ray1.85A/B50-212[»]
4CEZX-ray1.70A/B50-212[»]
4CF0X-ray1.85A/B50-212[»]
4CF1X-ray1.95A/B50-212[»]
4CF2X-ray1.95A/B50-212[»]
4CF8X-ray1.65A/B50-212[»]
4CF9X-ray2.10A/B50-212[»]
4CFAX-ray2.05A/B50-212[»]
4CFBX-ray1.95A/B50-212[»]
4CFCX-ray1.90A/B50-212[»]
4CFDX-ray2.15A/B50-212[»]
4CGDX-ray2.00A/B50-212[»]
4CGFX-ray1.70A/B50-212[»]
4CGGX-ray1.75A/B50-212[»]
4CGHX-ray1.76A/B50-212[»]
4CGIX-ray2.07A/B50-212[»]
4CGJX-ray2.15A/B50-212[»]
4CHNX-ray2.00A/B50-212[»]
4CHOX-ray1.70A/B50-212[»]
4CHPX-ray1.90A/B50-212[»]
4CHQX-ray1.95A/B50-212[»]
4CHYX-ray1.70A/B50-212[»]
4CHZX-ray1.80A/B50-212[»]
4CIEX-ray1.70A/B50-212[»]
4CIFX-ray1.80A/B50-212[»]
4CIGX-ray1.70A/B50-212[»]
4CJ3X-ray1.70A/B50-212[»]
4CJ4X-ray1.80A/B50-212[»]
4CJ5X-ray1.95A/B50-212[»]
4CJEX-ray1.90A/B50-212[»]
4CJFX-ray1.90A/B50-212[»]
4CJKX-ray1.75A/B50-212[»]
4CJLX-ray1.77A50-212[»]
4CJPX-ray2.00A/B50-212[»]
4CJQX-ray1.70A/B50-212[»]
4CJRX-ray1.80A/B50-212[»]
4CJSX-ray1.80A/B50-212[»]
4CJTX-ray1.71A/B50-212[»]
4CJUX-ray1.70A/B50-212[»]
4CJVX-ray1.95A/B50-212[»]
4CJWX-ray1.95A/B50-212[»]
4CK1X-ray1.75A/B50-212[»]
4CK2X-ray1.85A/B50-212[»]
4CK3X-ray1.79A/B50-212[»]
4LH4X-ray1.80A50-212[»]
4LH5X-ray2.19A50-212[»]
4OVLX-ray1.70A/B50-212[»]
4Y1CX-ray2.30A/B50-212[»]
4Y1DX-ray1.93A/B50-212[»]
5KGWX-ray2.34A50-212[»]
5KGXX-ray2.67A50-212[»]
5KRSX-ray1.70A57-207[»]
5KRTX-ray1.65A57-207[»]
5U1Celectron microscopy3.90A/B/C/D1-288[»]
ProteinModelPortaliQ76353.
SMRiQ76353.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ76353.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 44Integrase-typeInterPro annotationAdd BLAST42
Domaini54 – 204Integrase catalyticInterPro annotationAdd BLAST151
Domaini223 – 270Integrase-type DNA-bindingInterPro annotationAdd BLAST48

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.10.200. 1 hit.
2.30.30.10. 1 hit.
3.30.420.10. 1 hit.
InterProiView protein in InterPro
IPR001037. Integrase_C_retrovir.
IPR001584. Integrase_cat-core.
IPR017856. Integrase_Zn-bd_dom-like_N.
IPR003308. Integrase_Zn-bd_dom_N.
IPR012337. RNaseH-like_dom.
PfamiView protein in Pfam
PF00552. IN_DBD_C. 1 hit.
PF02022. Integrase_Zn. 1 hit.
PF00665. rve. 1 hit.
SUPFAMiSSF46919. SSF46919. 1 hit.
SSF50122. SSF50122. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiView protein in PROSITE
PS50994. INTEGRASE. 1 hit.
PS51027. INTEGRASE_DBD. 1 hit.
PS50876. ZF_INTEGRASE. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q76353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FLDGIDKAQE EHEKYHSNWR AMASDFNLPP VVAKEIVASC DKCQLKGEAM
60 70 80 90 100
HGQVDCSPGI WQLDCTHLEG KVILVAVHVA SGYIEAEVIP AETGQETAYF
110 120 130 140 150
LLKLAGRWPV KTVHTDNGSN FTSTTVKAAC WWAGIKQEFG IPYNPQSQGV
160 170 180 190 200
IESMNKELKK IIGQVRDQAE HLKTAVQMAV FIHNFKRKGG IGGYSAGERI
210 220 230 240 250
VDIIATDIQT KELQKQITKI QNFRVYYRDS RDPVWKGPAK LLWKGEGAVV
260 270 280
IQDNSDIKVV PRRKAKIIRD YGKQMAGDDC VASRQDED
Length:288
Mass (Da):32,199
Last modified:November 1, 1996 - v1
Checksum:i0680E5CD1E201580
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21188 Unassigned RNA. Translation: AAC37875.1.

Similar proteinsi

Entry informationi

Entry nameiQ76353_9HIV1
AccessioniPrimary (citable) accession number: Q76353
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources