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Protein

UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter

Gene

Slc35d2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
Alternative name(s):
Solute carrier family 35 member D2
UDP-galactose transporter-related protein 8
Short name:
UGTrel8
Gene namesi
Name:Slc35d2
Synonyms:Ugtrel8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917734. Slc35d2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515ExtracellularSequence analysisAdd
BLAST
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Topological domaini37 – 415CytoplasmicSequence analysis
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Topological domaini63 – 13068ExtracellularSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Topological domaini152 – 1554CytoplasmicSequence analysis
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Topological domaini177 – 18913ExtracellularSequence analysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST
Topological domaini211 – 22515CytoplasmicSequence analysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Topological domaini247 – 2537ExtracellularSequence analysis
Transmembranei254 – 27623HelicalSequence analysisAdd
BLAST
Topological domaini277 – 2804CytoplasmicSequence analysis
Transmembranei281 – 30323HelicalSequence analysisAdd
BLAST
Topological domaini304 – 32623ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporterPRO_0000313081Add
BLAST

Proteomic databases

MaxQBiQ762D5.
PaxDbiQ762D5.
PRIDEiQ762D5.

Expressioni

Gene expression databases

BgeeiQ762D5.
CleanExiMM_SLC35D2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097040.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1444. Eukaryota.
COG5070. LUCA.
HOGENOMiHOG000038339.
HOVERGENiHBG054071.
InParanoidiQ762D5.
KOiK15281.
OrthoDBiEOG76DTT0.
PhylomeDBiQ762D5.
TreeFamiTF313307.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q762D5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEPNAAPLP SRLARLLSAL FYGTCSFLIV LVNKALLTTY GFPSPIVLGI
60 70 80 90 100
GQMATTIMIL YVFKLNKIIH FPDFDKKIPG KLFPLPLLYV GNHISGLSST
110 120 130 140 150
SKLSLPMFTV LRKFTIPFTL LLEAIILGTQ YSLNIILSVL AIVLGAFIAA
160 170 180 190 200
GSDLTFNLEG YVFVFLNDIF TAANGVYTKQ KMDPKELGKY GVLFYNACFM
210 220 230 240 250
LIPTVIISVS TGDFQQATEF RHWKNVLFII QFLLSCLLGF LLMYSTALCS
260 270 280 290 300
YYNSALTTAV VGAIKNVSVA YIGMLVGGDY IFSLLNFIGL NICMAGGLRY
310 320
SFLTLSSQLK PKQPVDEESI PLDLKS
Length:326
Mass (Da):35,896
Last modified:July 5, 2004 - v1
Checksum:iF469DC23D635DB2F
GO
Isoform 2 (identifier: Q762D5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-283: NVSVAYIGMLVGGDYIFS → HGRWFKIFLFNTQQPVET
     284-326: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):31,507
Checksum:i6FDBFEA463ECC858
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti162 – 1621V → I in BAE34855 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei266 – 28318NVSVA…DYIFS → HGRWFKIFLFNTQQPVET in isoform 2. 1 PublicationVSP_030007Add
BLAST
Alternative sequencei284 – 32643Missing in isoform 2. 1 PublicationVSP_030008Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB117931 mRNA. Translation: BAD18884.1.
AB117932 mRNA. Translation: BAD18885.1.
AK154257 mRNA. Translation: BAE32469.1.
AK159148 mRNA. Translation: BAE34855.1.
BC046402 mRNA. Translation: AAH46402.1.
BC107211 mRNA. Translation: AAI07212.1.
CCDSiCCDS26595.1. [Q762D5-1]
RefSeqiNP_001001321.2. NM_001001321.3.
UniGeneiMm.133731.

Genome annotation databases

GeneIDi70484.
KEGGimmu:70484.
UCSCiuc007qyg.1. mouse. [Q762D5-1]
uc007qyi.1. mouse. [Q762D5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB117931 mRNA. Translation: BAD18884.1.
AB117932 mRNA. Translation: BAD18885.1.
AK154257 mRNA. Translation: BAE32469.1.
AK159148 mRNA. Translation: BAE34855.1.
BC046402 mRNA. Translation: AAH46402.1.
BC107211 mRNA. Translation: AAI07212.1.
CCDSiCCDS26595.1. [Q762D5-1]
RefSeqiNP_001001321.2. NM_001001321.3.
UniGeneiMm.133731.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097040.

Proteomic databases

MaxQBiQ762D5.
PaxDbiQ762D5.
PRIDEiQ762D5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi70484.
KEGGimmu:70484.
UCSCiuc007qyg.1. mouse. [Q762D5-1]
uc007qyi.1. mouse. [Q762D5-2]

Organism-specific databases

CTDi11046.
MGIiMGI:1917734. Slc35d2.

Phylogenomic databases

eggNOGiKOG1444. Eukaryota.
COG5070. LUCA.
HOGENOMiHOG000038339.
HOVERGENiHBG054071.
InParanoidiQ762D5.
KOiK15281.
OrthoDBiEOG76DTT0.
PhylomeDBiQ762D5.
TreeFamiTF313307.

Miscellaneous databases

ChiTaRSiSlc35d2. mouse.
PROiQ762D5.
SOURCEiSearch...

Gene expression databases

BgeeiQ762D5.
CleanExiMM_SLC35D2.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Targeted inactivation of the mouse UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter gene."
    Hiraoka S., Ogawa M., Koseki H.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiS35D2_MOUSE
AccessioniPrimary (citable) accession number: Q762D5
Secondary accession number(s): Q3TXR0, Q762D4, Q811G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.