Q762C8 (Q762C8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
HUp84 EMBL BAD16649.1

Gene names

Name:

CAPN3 EMBL BAD16649.1

Organism

Homo sapiens (Human) EMBL BAD16649.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	728 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 calpain catalytic domain. SAAS SAAS022683

Ontologies

Keywords
Ligand	Calcium RuleBase RU000331
Molecular function	Hydrolase Protease Thiol protease SAAS SAAS001300
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro calcium-dependent cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q762C8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 565ED6138908F5F0	FASTA	728	84,084
	10 20 30 40 50 60 MSWQISLKTQ TTQQKNEICE NPRFIIDGAN RTDICQGELG DCWFLAAIAC LTLNQHLLFR 70 80 90 100 110 120 VIPHDQSFIE NYAGIFHFQF WRYGEWVDVV IDDCLPTYNN QLVFTKSNHR NEFWSALLEK 130 140 150 160 170 180 AYAKLHGSYE ALKGGNTTEA MEDFTGGVAE FFEIRDAPSD MYKIMKKAIE RGSLMGCSID 190 200 210 220 230 240 DGTNMAYGTS PSGLNMGELI ARMVRNMDNS LLQGSDLDPR GSDERPTRTI IPVQYETRMA 250 260 270 280 290 300 CGLVRGHAYS VTELDEVPFK GEKVKLVRLR NPWGQVEWNG SWSDRWKDWS FVDKDEKARL 310 320 330 340 350 360 QHQVTEDGEF WMSYEDFIYH FTKLEICNLT ADALQSDKLQ TWTVSVNEGR WVRGCSAGGC 370 380 390 400 410 420 RNFPDTFWTN PQYRLKLLEE DDDPDDSEVI CSFLVALMQK NRRKDRKLGA SLFTIGFAIY 430 440 450 460 470 480 EVPKEMHGNK QHLQKDFFLY NASKARSKTY INMREVSQRF RLPPSEYVIV PSTYEPHQEG 490 500 510 520 530 540 EFILRVFSEK RNLSEEVENT ISVDRPVPII FVSDRANSNK ELGVDQESEE GKGKTSPDKQ 550 560 570 580 590 600 KQSPQPQPGS SDQESEEQQQ FRNIFKQIAG DDMEICADEL KKVLNTVVNK HKDLKTHGFT 610 620 630 640 650 660 LESCRSMIAL MDTDGSGKLN LQEFHHLWNK IKAWQKIFKH YDTDQSGTIN SYEMRNAVND 670 680 690 700 710 720 AGFHLNNQLY DIITMRYADK HMNIDFDSFI CCFVRLEGMF RAFHAFDKDG DGIIKLNVLE WLQLTMYA

References

[1]	"Newly identified exons encoding novel variants of p94/calpain 3 are expressed ubiquitously and overlap the alpha-glucosidase C gene." Kawabata Y., Hata S., Ono Y., Ito Y., Suzuki K., Abe K., Sorimachi H. FEBS Lett. 555:623-630(2003) [PubMed: 14675785] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Yukiko K., Sorimachi H. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB117940 mRNA. Translation: BAD16649.1.
IPI	IPI00218764.
UniGene	Hs.143261.
3D structure databases
HSSP	HSSP built from PDB template 1KFX based on UniProtKB P17655.
ProteinModelPortal	Q762C8.
SMR	Q762C8. Positions 6-330, 556-728.
ModBase	Search...
Protein-protein interaction databases
STRING	Q762C8.
Proteomic databases
PRIDE	Q762C8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc001zpl.1. human.
Phylogenomic databases
HOVERGEN	HBG012645.
Gene expression databases
ArrayExpress	Q762C8.
Family and domain databases
InterPro	IPR022684. Calpain_cysteine_protease. IPR022682. Calpain_domain_III. IPR022683. Calpain_III. IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca-bd. IPR000169. Pept_cys_AS. IPR001300. Peptidase_C2_calpain_cat. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
Pfam	PF01067. Calpain_III. 1 hit. PF00648. Peptidase_C2. 2 hits. [Graphical view]
PRINTS	PR00704. CALPAIN.
SMART	SM00720. calpain_III. 1 hit. SM00230. CysPc. 1 hit. SM00054. EFh. 3 hits. [Graphical view]
SUPFAM	SSF49758. Peptidase_C2. 1 hit.
PROSITE	PS50203. CALPAIN_CAT. 1 hit. PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 4 hits. PS00139. THIOL_PROTEASE_CYS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	3378.

Entry information

Entry name

Q762C8_HUMAN

Accession

Primary (citable) accession number: Q762C8

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	November 16, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.