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Protein
Submitted name:

ATP7A protein

Gene

ATP7A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ATP7A proteinImported
Gene namesi
Name:ATP7AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA72.

PTM / Processingi

Proteomic databases

PaxDbiQ762B6.
PRIDEiQ762B6.

Expressioni

Gene expression databases

ExpressionAtlasiQ762B6. baseline and differential.
GenevisibleiQ762B6. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345728.

Structurei

3D structure databases

ProteinModelPortaliQ762B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 7567HMAInterPro annotationAdd
BLAST
Domaini172 – 23867HMAInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0207. Eukaryota.
COG2217. LUCA.
GeneTreeiENSGT00530000063773.
HOVERGENiHBG065948.
KOiK17686.

Family and domain databases

InterProiIPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
[Graphical view]
PfamiPF00403. HMA. 2 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
TIGRFAMsiTIGR00003. TIGR00003. 2 hits.
PROSITEiPS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q762B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSMGVNSV TISVEGMTCN SCVWTIEQQI GKVNGVHHIK VSLEEKNATI
60 70 80 90 100
IYDPKLQTPK TLQEAIDDMG FDAVIHNPDP LPVLTDTLFL TVTASLTLPW
110 120 130 140 150
DHIQSTLLKT KGVTDIKIYP QKRTVAVTII PSIVNANQIK ELVPELSLDT
160 170 180 190 200
GTLEKKSGAC EDHSMAQAGE VVLKMKVEGM TCHSCTSTIE GKIGKLQGVQ
210 220 230 240 250
RIKVSLDNQE ATIVYQPHLI SVEEMKKQIE AMGFPAFVKK QPKYLKLGAI
260 270
DVERLKNTPV KSSEGSQQRS PSYQ
Length:274
Mass (Da):30,124
Last modified:July 5, 2004 - v1
Checksum:i1233AE33CD302122
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB117973 mRNA. Translation: BAC82353.1.
RefSeqiNP_000043.4. NM_000052.6.
NP_001269153.1. NM_001282224.1.
UniGeneiHs.496414.
Hs.733232.

Genome annotation databases

GeneIDi538.
KEGGihsa:538.
UCSCiuc065abx.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB117973 mRNA. Translation: BAC82353.1.
RefSeqiNP_000043.4. NM_000052.6.
NP_001269153.1. NM_001282224.1.
UniGeneiHs.496414.
Hs.733232.

3D structure databases

ProteinModelPortaliQ762B6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000345728.

Proteomic databases

PaxDbiQ762B6.
PRIDEiQ762B6.

Protocols and materials databases

DNASUi538.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi538.
KEGGihsa:538.
UCSCiuc065abx.1. human.

Organism-specific databases

CTDi538.
PharmGKBiPA72.

Phylogenomic databases

eggNOGiKOG0207. Eukaryota.
COG2217. LUCA.
GeneTreeiENSGT00530000063773.
HOVERGENiHBG065948.
KOiK17686.

Miscellaneous databases

ChiTaRSiATP7A. human.
GenomeRNAii538.

Gene expression databases

ExpressionAtlasiQ762B6. baseline and differential.
GenevisibleiQ762B6. HS.

Family and domain databases

InterProiIPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
[Graphical view]
PfamiPF00403. HMA. 2 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
TIGRFAMsiTIGR00003. TIGR00003. 2 hits.
PROSITEiPS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Novel mutation of ATP7A (Menkes disease), (819-820 del TA in exon 4, which cause frameshift and termination codon)."
    Ueta A., Ito T., Sumi S., Ohkubo Y., Yamazaki D., Hironou T., Ban K., Togari H.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ762B6_HUMAN
AccessioniPrimary (citable) accession number: Q762B6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.