Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q761V0 (SC6A5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium- and chloride-dependent glycine transporter 2

Short name=GlyT-2
Short name=GlyT2
Alternative name(s):
Solute carrier family 6 member 5
Gene names
Name:Slc6a5
Synonyms:Glyt2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length799 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Isoform a and isoform b are expressed at high levels in brain stem and spinal cord. Isoform a is also expressed in the cerebellum. Ref.1

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A5 subfamily. [View classification]

Ontologies

Keywords
   Biological processNeurotransmitter transport
Symport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionneurotransmitter:sodium symporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a Ref.1 (identifier: Q761V0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform b Ref.1 (identifier: Q761V0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 799799Sodium- and chloride-dependent glycine transporter 2
PRO_0000214763

Regions

Topological domain1 – 201201Cytoplasmic Potential
Transmembrane202 – 22221Helical; Name=1; Potential
Transmembrane229 – 24921Helical; Name=2; Potential
Transmembrane273 – 29321Helical; Name=3; Potential
Topological domain294 – 396103Extracellular Potential
Transmembrane397 – 41721Helical; Name=4; Potential
Transmembrane433 – 45321Helical; Name=5; Potential
Transmembrane472 – 49221Helical; Name=6; Potential
Transmembrane510 – 53021Helical; Name=7; Potential
Transmembrane565 – 58521Helical; Name=8; Potential
Transmembrane611 – 63121Helical; Name=9; Potential
Transmembrane640 – 66021Helical; Name=10; Potential
Transmembrane677 – 69721Helical; Name=11; Potential
Transmembrane717 – 73721Helical; Name=12; Potential
Topological domain738 – 79962Cytoplasmic Potential

Amino acid modifications

Glycosylation3451N-linked (GlcNAc...) Potential
Glycosylation3551N-linked (GlcNAc...) Potential
Glycosylation3601N-linked (GlcNAc...) Potential
Glycosylation3661N-linked (GlcNAc...) Potential
Glycosylation7141N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 88Missing in isoform b. Ref.1
VSP_051603

Experimental info

Sequence conflict1511V → E in AAL17054. Ref.2
Sequence conflict1511V → E in AAN11408. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 92AC7750C7023D45

FASTA79987,861
        10         20         30         40         50         60 
MDCSAPKEMN KQPANILEAA VPGHRDSPRA PRTSPEQDLP AEAPAATVQP PRVPRSASTG 

        70         80         90        100        110        120 
AQTFQSADAR ACEAQQSGVG FCNLSSPRAQ ATSAALRDLS EGHSAQANPP SGPAGAGNAL 

       130        140        150        160        170        180 
HCKIPALRGP EEDANVSVGK GTLEHNNTPA VGWVNMSQST VVLGTDGIAS VLPGSVATTT 

       190        200        210        220        230        240 
IPEDEQGDEN KARGNWSSKL DFILSMVGYA VGLGNVWRFP YLAFQNGGGA FLIPYLMMLA 

       250        260        270        280        290        300 
LAGLPIFFLE VSLGQFASQG PVSVWKAIPA LQGCGIAMLI ISVLIAIYYN VIICYTLFYL 

       310        320        330        340        350        360 
FASFVSVLPW GSCNNPWNTP ECKDKTKLLL DSCVIGDHPK IQIKNSTFCM TAYPNLTMVN 

       370        380        390        400        410        420 
FTSQTNKTFV SGSEEYFKYF VLKISAGIEY PGEIRWPLAF CLFLAWVIVY ASLAKGIKSS 

       430        440        450        460        470        480 
GKVVYFTATF PYVVLVILLI RGVTLPGAGA GIWYFITPKW EKLTDATVWK DAATQIFFSL 

       490        500        510        520        530        540 
SAAWGGLITL SSYNKFHNNC YRDTLIVTCT NSATSIFAGF VIFSVIGFMA NERKVNIENV 

       550        560        570        580        590        600 
ADQGPGIAFV VYPEALTRLP LSPFWAIIFF LMLLTLGLDT MFATIETIVT SISDEFPKYL 

       610        620        630        640        650        660 
RTHKPVFTLG CCICFFIMGF PMITQGGIYM FQLVDTYAAS YALVIIAIFE LVGISYVYGL 

       670        680        690        700        710        720 
QRFCEDIEMM IGFKPNIFWK VCWAFVTPTI LTFILCFSFY QWEPMTYGSY RYPNWSMVLG 

       730        740        750        760        770        780 
WLMLACSVIW IPIMFVIKMY LAPGRFIERL KLVCSPQPDW GPFLAQHRGE RYKNMIDPLG 

       790 
TSSLGLKLPV KDLELGTQC 

« Hide

Isoform b [UniParc].

Checksum: 5F7051201736EC01
Show »

FASTA79186,999

References

[1]"Gene structure and alternative splicing of the mouse glycine transporter type-2."
Ebihara S., Yamamoto T., Obata K., Yanagawa Y.
Biochem. Biophys. Res. Commun. 317:857-864(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), TISSUE SPECIFICITY.
Strain: 129/Sv.
[2]"Cloning and expression of mouse sodium-dependent glycine transporter 2 (Glyt2)."
Liu Q.-R., Li Q.-F.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
Strain: BALB/c.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB118159 mRNA. Translation: BAD16781.1.
AF411042 mRNA. Translation: AAL17054.1.
AY147186 mRNA. Translation: AAN11408.1.
CCDSCCDS21308.1. [Q761V0-2]
UniGeneMm.207053.

3D structure databases

ProteinModelPortalQ761V0.
SMRQ761V0. Positions 193-759.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ761V0. 1 interaction.
MINTMINT-4133901.

Protein family/group databases

TCDB2.A.22.2.6. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSiteQ761V0.

Proteomic databases

MaxQBQ761V0.
PaxDbQ761V0.
PRIDEQ761V0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc012fle.1. mouse. [Q761V0-1]

Organism-specific databases

MGIMGI:105090. Slc6a5.

Phylogenomic databases

eggNOGCOG0733.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidQ761V0.
PhylomeDBQ761V0.

Gene expression databases

GenevestigatorQ761V0.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR00176. NANEUSMPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ761V0.
SOURCESearch...

Entry information

Entry nameSC6A5_MOUSE
AccessionPrimary (citable) accession number: Q761V0
Secondary accession number(s): Q8CFM5, Q91ZQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot