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Q761V0

- SC6A5_MOUSE

UniProt

Q761V0 - SC6A5_MOUSE

Protein

Sodium- and chloride-dependent glycine transporter 2

Gene

Slc6a5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses By similarity.By similarity

    GO - Molecular functioni

    1. neurotransmitter:sodium symporter activity Source: InterPro

    Keywords - Biological processi

    Neurotransmitter transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.22.2.6. the neurotransmitter:sodium symporter (nss) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent glycine transporter 2
    Short name:
    GlyT-2
    Short name:
    GlyT2
    Alternative name(s):
    Solute carrier family 6 member 5
    Gene namesi
    Name:Slc6a5Imported
    Synonyms:Glyt2Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:105090. Slc6a5.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 799799Sodium- and chloride-dependent glycine transporter 2PRO_0000214763Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi714 – 7141N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ761V0.
    PaxDbiQ761V0.
    PRIDEiQ761V0.

    PTM databases

    PhosphoSiteiQ761V0.

    Expressioni

    Tissue specificityi

    Isoform a and isoform b are expressed at high levels in brain stem and spinal cord. Isoform a is also expressed in the cerebellum.1 Publication

    Gene expression databases

    GenevestigatoriQ761V0.

    Interactioni

    Protein-protein interaction databases

    IntActiQ761V0. 1 interaction.
    MINTiMINT-4133901.

    Structurei

    3D structure databases

    ProteinModelPortaliQ761V0.
    SMRiQ761V0. Positions 193-759.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 201201CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini294 – 396103ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini738 – 79962CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei202 – 22221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei397 – 41721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei433 – 45321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei472 – 49221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei510 – 53021Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei565 – 58521Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei611 – 63121Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei640 – 66021Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei677 – 69721Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei717 – 73721Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiQ761V0.
    PhylomeDBiQ761V0.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR00176. NANEUSMPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a1 Publication (identifier: Q761V0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDCSAPKEMN KQPANILEAA VPGHRDSPRA PRTSPEQDLP AEAPAATVQP    50
    PRVPRSASTG AQTFQSADAR ACEAQQSGVG FCNLSSPRAQ ATSAALRDLS 100
    EGHSAQANPP SGPAGAGNAL HCKIPALRGP EEDANVSVGK GTLEHNNTPA 150
    VGWVNMSQST VVLGTDGIAS VLPGSVATTT IPEDEQGDEN KARGNWSSKL 200
    DFILSMVGYA VGLGNVWRFP YLAFQNGGGA FLIPYLMMLA LAGLPIFFLE 250
    VSLGQFASQG PVSVWKAIPA LQGCGIAMLI ISVLIAIYYN VIICYTLFYL 300
    FASFVSVLPW GSCNNPWNTP ECKDKTKLLL DSCVIGDHPK IQIKNSTFCM 350
    TAYPNLTMVN FTSQTNKTFV SGSEEYFKYF VLKISAGIEY PGEIRWPLAF 400
    CLFLAWVIVY ASLAKGIKSS GKVVYFTATF PYVVLVILLI RGVTLPGAGA 450
    GIWYFITPKW EKLTDATVWK DAATQIFFSL SAAWGGLITL SSYNKFHNNC 500
    YRDTLIVTCT NSATSIFAGF VIFSVIGFMA NERKVNIENV ADQGPGIAFV 550
    VYPEALTRLP LSPFWAIIFF LMLLTLGLDT MFATIETIVT SISDEFPKYL 600
    RTHKPVFTLG CCICFFIMGF PMITQGGIYM FQLVDTYAAS YALVIIAIFE 650
    LVGISYVYGL QRFCEDIEMM IGFKPNIFWK VCWAFVTPTI LTFILCFSFY 700
    QWEPMTYGSY RYPNWSMVLG WLMLACSVIW IPIMFVIKMY LAPGRFIERL 750
    KLVCSPQPDW GPFLAQHRGE RYKNMIDPLG TSSLGLKLPV KDLELGTQC 799
    Length:799
    Mass (Da):87,861
    Last modified:July 5, 2004 - v1
    Checksum:i92AC7750C7023D45
    GO
    Isoform b1 Publication (identifier: Q761V0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-8: Missing.

    Show »
    Length:791
    Mass (Da):86,999
    Checksum:i5F7051201736EC01
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti151 – 1511V → E in AAL17054. 1 PublicationCurated
    Sequence conflicti151 – 1511V → E in AAN11408. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 88Missing in isoform b. 2 PublicationsVSP_051603

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB118159 mRNA. Translation: BAD16781.1.
    AF411042 mRNA. Translation: AAL17054.1.
    AY147186 mRNA. Translation: AAN11408.1.
    CCDSiCCDS21308.1. [Q761V0-2]
    UniGeneiMm.207053.

    Genome annotation databases

    UCSCiuc012fle.1. mouse. [Q761V0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB118159 mRNA. Translation: BAD16781.1 .
    AF411042 mRNA. Translation: AAL17054.1 .
    AY147186 mRNA. Translation: AAN11408.1 .
    CCDSi CCDS21308.1. [Q761V0-2 ]
    UniGenei Mm.207053.

    3D structure databases

    ProteinModelPortali Q761V0.
    SMRi Q761V0. Positions 193-759.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q761V0. 1 interaction.
    MINTi MINT-4133901.

    Protein family/group databases

    TCDBi 2.A.22.2.6. the neurotransmitter:sodium symporter (nss) family.

    PTM databases

    PhosphoSitei Q761V0.

    Proteomic databases

    MaxQBi Q761V0.
    PaxDbi Q761V0.
    PRIDEi Q761V0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc012fle.1. mouse. [Q761V0-1 ]

    Organism-specific databases

    MGIi MGI:105090. Slc6a5.

    Phylogenomic databases

    eggNOGi COG0733.
    HOGENOMi HOG000116406.
    HOVERGENi HBG071421.
    InParanoidi Q761V0.
    PhylomeDBi Q761V0.

    Miscellaneous databases

    PROi Q761V0.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q761V0.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR00176. NANEUSMPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene structure and alternative splicing of the mouse glycine transporter type-2."
      Ebihara S., Yamamoto T., Obata K., Yanagawa Y.
      Biochem. Biophys. Res. Commun. 317:857-864(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), TISSUE SPECIFICITY.
      Strain: 129/SvImported.
    2. "Cloning and expression of mouse sodium-dependent glycine transporter 2 (Glyt2)."
      Liu Q.-R., Li Q.-F.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
      Strain: BALB/cImported.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiSC6A5_MOUSE
    AccessioniPrimary (citable) accession number: Q761V0
    Secondary accession number(s): Q8CFM5, Q91ZQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3