Reviewed, UniProtKB/Swiss-Prot Q75ZX4 (ADH1_ORYSI)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1

Gene names

Name:	ADH1
ORF Names:	OsI_034290

Organism

Oryza sativa subsp. indica (Rice)

Taxonomic identifier

39946 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit.
Subunit structure	Homodimer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 379	379	Alcohol dehydrogenase 1		PRO_0000291461
Sites
	Metal binding	47	1	Zinc 1; catalytic By similarity
	Metal binding	69	1	Zinc 1; catalytic By similarity
	Metal binding	100	1	Zinc 2 By similarity
	Metal binding	102	1	Zinc 2 By similarity
	Metal binding	105	1	Zinc 2 By similarity
	Metal binding	113	1	Zinc 2 By similarity
	Metal binding	177	1	Zinc 1; catalytic By similarity
Experimental info
	Sequence conflict	19	1	A → G in CAA34363. Ref.1
	Sequence conflict	23	1	V → S in CAA34363. Ref.1
	Sequence conflict	31 – 34	4	PPQA → KE in CAA34363. Ref.1
	Sequence conflict	144	1	V → I in CAA34363. Ref.1
	Sequence conflict	192	1	Missing in CAA34363. Ref.1
	Sequence conflict	217	1	A → R in CAA34363. Ref.1
	Sequence conflict	291	1	V → I in CAA34363. Ref.1
	Sequence conflict	370	1	G → A in CAA34363. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q75ZX4-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1281E87F3DB30545	FASTA	379	40,984
	10 20 30 40 50 60 MATAGKVIKC KAAVAWEAAK PLVIEEVEVA PPQAMEVRVK ILFTSLCHTD VYFWEAKGQT 70 80 90 100 110 120 PVFPRIFGHE AGGIVESVGE GVTDLAPGDH VLPVFTGECK ECAHCKSAES NMCDLLRINT 130 140 150 160 170 180 DRGVMIGDGK SRFSINGKPI YHFVGTSTFS EYTVMHVGCV AKINPAAPLD KVCVLSCGIS 190 200 210 220 230 240 TGLGATINVA KPPKGSTVAI FGLGAVGLAA AEGARIAGAS RIIGIDLNAN RFEEARKFGC 250 260 270 280 290 300 TEFVNPKDHD KPVQQVLAEM TNGGVDRSVE CTGNINAMIQ AFECVHDGWG VAVLVGVPHK 310 320 330 340 350 360 DAEFKTHPMN FLNERTLKGT FFGNYKPRTD LPNVVELYMK KELEVEKFIT HSVPFSEINT 370 AFDLMHKGEG IRCIIRMEN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rice alcohol dehydrogenase genes: anaerobic induction, organ specific expression and characterization of cDNA clones." Xie Y., Wu R. Plant Mol. Biol. 13:53-68(1989) [PubMed: 2562760] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. IR26. Tissue: Seedling.
[2]	"Nucleotide polymorphism in the Adh1 locus region of the wild rice Oryza rufipogon." Yoshida K., Miyashita N.T., Ishii T. Theor. Appl. Genet. 109:1406-1416(2004) [PubMed: 15480535] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The genomes of Oryza sativa: a history of duplications." Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H. PLoS Biol. 3:266-281(2005) [PubMed: 15685292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. 93-11.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X16296 mRNA. Translation: CAA34363.1. AB118962 Genomic DNA. Translation: BAC87776.1. CM000136 Genomic DNA. Translation: EAY80331.1.
PIR	JQ0474.
3D structure databases
HSSP	HSSP built from PDB template 1M6H based on UniProtKB P11766.
ModBase	Search...
Organism-specific databases
Gramene	Q75ZX4.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002328. AlcDHase_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH1_ORYSI

Accession

Primary (citable) accession number: Q75ZX4
Secondary accession number(s): P20306

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	July 5, 2004
Last modified:	November 25, 2008
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)