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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi49Zinc 1By similarity1
Binding sitei49NADBy similarity1
Binding sitei49SubstrateBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Binding sitei69SubstrateBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi177Zinc 1; catalyticBy similarity1
Binding sitei226NADBy similarity1
Binding sitei231NADBy similarity1
Binding sitei272NAD; via carbonyl oxygenBy similarity1
Binding sitei295NAD; via carbonyl oxygenBy similarity1
Binding sitei322NAD; via amide nitrogenBy similarity1
Binding sitei372NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 207NADBy similarity6
Nucleotide bindingi295 – 297NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1By similarity)
Gene namesi
Name:ADH1
ORF Names:OsI_034290
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000007015 Componenti: Chromosome 11

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002914611 – 379Alcohol dehydrogenase 1Add BLAST379

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi39946.BGIOSGA034312-PA.

Structurei

3D structure databases

ProteinModelPortaliQ75ZX4.
SMRiQ75ZX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.
OMAiDMRSGRN.
OrthoDBiEOG09360BVQ.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q75ZX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAGKVIKC KAAVAWEAAK PLVIEEVEVA PPQAMEVRVK ILFTSLCHTD
60 70 80 90 100
VYFWEAKGQT PVFPRIFGHE AGGIVESVGE GVTDLAPGDH VLPVFTGECK
110 120 130 140 150
ECAHCKSAES NMCDLLRINT DRGVMIGDGK SRFSINGKPI YHFVGTSTFS
160 170 180 190 200
EYTVMHVGCV AKINPAAPLD KVCVLSCGIS TGLGATINVA KPPKGSTVAI
210 220 230 240 250
FGLGAVGLAA AEGARIAGAS RIIGIDLNAN RFEEARKFGC TEFVNPKDHD
260 270 280 290 300
KPVQQVLAEM TNGGVDRSVE CTGNINAMIQ AFECVHDGWG VAVLVGVPHK
310 320 330 340 350
DAEFKTHPMN FLNERTLKGT FFGNYKPRTD LPNVVELYMK KELEVEKFIT
360 370
HSVPFSEINT AFDLMHKGEG IRCIIRMEN
Length:379
Mass (Da):40,984
Last modified:July 5, 2004 - v1
Checksum:i1281E87F3DB30545
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19A → G in CAA34363 (PubMed:2562760).Curated1
Sequence conflicti23V → S in CAA34363 (PubMed:2562760).Curated1
Sequence conflicti31 – 34PPQA → KE in CAA34363 (PubMed:2562760).Curated4
Sequence conflicti144V → I in CAA34363 (PubMed:2562760).Curated1
Sequence conflicti192Missing in CAA34363 (PubMed:2562760).Curated1
Sequence conflicti217A → R in CAA34363 (PubMed:2562760).Curated1
Sequence conflicti291V → I in CAA34363 (PubMed:2562760).Curated1
Sequence conflicti370G → A in CAA34363 (PubMed:2562760).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16296 mRNA. Translation: CAA34363.1.
AB118962 Genomic DNA. Translation: BAC87776.1.
CM000136 Genomic DNA. Translation: EAY80331.1.
PIRiJQ0474.

Genome annotation databases

EnsemblPlantsiBGIOSGA034312-TA; BGIOSGA034312-PA; BGIOSGA034312.
GrameneiBGIOSGA034312-TA; BGIOSGA034312-PA; BGIOSGA034312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16296 mRNA. Translation: CAA34363.1.
AB118962 Genomic DNA. Translation: BAC87776.1.
CM000136 Genomic DNA. Translation: EAY80331.1.
PIRiJQ0474.

3D structure databases

ProteinModelPortaliQ75ZX4.
SMRiQ75ZX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39946.BGIOSGA034312-PA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiBGIOSGA034312-TA; BGIOSGA034312-PA; BGIOSGA034312.
GrameneiBGIOSGA034312-TA; BGIOSGA034312-PA; BGIOSGA034312.

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.
OMAiDMRSGRN.
OrthoDBiEOG09360BVQ.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_ORYSI
AccessioniPrimary (citable) accession number: Q75ZX4
Secondary accession number(s): P20306
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.