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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi49Zinc 1By similarity1
Binding sitei49NADBy similarity1
Binding sitei49SubstrateBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Binding sitei69SubstrateBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi177Zinc 1; catalyticBy similarity1
Binding sitei226NADBy similarity1
Binding sitei231NADBy similarity1
Binding sitei272NAD; via carbonyl oxygenBy similarity1
Binding sitei295NAD; via carbonyl oxygenBy similarity1
Binding sitei322NAD; via amide nitrogenBy similarity1
Binding sitei372NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 207NADBy similarity6
Nucleotide bindingi295 – 297NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1By similarity)
Gene namesi
Name:ADH1
ORF Names:OsI_034290
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000007015 Componenti: Chromosome 11

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002914611 – 379Alcohol dehydrogenase 1Add BLAST379

Expressioni

Gene expression databases

ExpressionAtlasiQ75ZX4 baseline and differential

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi39946.BGIOSGA034312-PA

Structurei

3D structure databases

ProteinModelPortaliQ75ZX4
SMRiQ75ZX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
OMAiSNETYNE
OrthoDBiEOG09360BVQ

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q75ZX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAGKVIKC KAAVAWEAAK PLVIEEVEVA PPQAMEVRVK ILFTSLCHTD
60 70 80 90 100
VYFWEAKGQT PVFPRIFGHE AGGIVESVGE GVTDLAPGDH VLPVFTGECK
110 120 130 140 150
ECAHCKSAES NMCDLLRINT DRGVMIGDGK SRFSINGKPI YHFVGTSTFS
160 170 180 190 200
EYTVMHVGCV AKINPAAPLD KVCVLSCGIS TGLGATINVA KPPKGSTVAI
210 220 230 240 250
FGLGAVGLAA AEGARIAGAS RIIGIDLNAN RFEEARKFGC TEFVNPKDHD
260 270 280 290 300
KPVQQVLAEM TNGGVDRSVE CTGNINAMIQ AFECVHDGWG VAVLVGVPHK
310 320 330 340 350
DAEFKTHPMN FLNERTLKGT FFGNYKPRTD LPNVVELYMK KELEVEKFIT
360 370
HSVPFSEINT AFDLMHKGEG IRCIIRMEN
Length:379
Mass (Da):40,984
Last modified:July 5, 2004 - v1
Checksum:i1281E87F3DB30545
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19A → G in CAA34363 (PubMed:2562760).Curated1
Sequence conflicti23V → S in CAA34363 (PubMed:2562760).Curated1
Sequence conflicti31 – 34PPQA → KE in CAA34363 (PubMed:2562760).Curated4
Sequence conflicti144V → I in CAA34363 (PubMed:2562760).Curated1
Sequence conflicti192Missing in CAA34363 (PubMed:2562760).Curated1
Sequence conflicti217A → R in CAA34363 (PubMed:2562760).Curated1
Sequence conflicti291V → I in CAA34363 (PubMed:2562760).Curated1
Sequence conflicti370G → A in CAA34363 (PubMed:2562760).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16296 mRNA Translation: CAA34363.1
AB118962 Genomic DNA Translation: BAC87776.1
CM000136 Genomic DNA Translation: EAY80331.1
PIRiJQ0474

Genome annotation databases

EnsemblPlantsiBGIOSGA034312-TA; BGIOSGA034312-PA; BGIOSGA034312
Os11t0210300-01; Os11t0210300-01; Os11g0210300
GrameneiBGIOSGA034312-TA; BGIOSGA034312-PA; BGIOSGA034312
Os11t0210300-01; Os11t0210300-01; Os11g0210300

Similar proteinsi

Entry informationi

Entry nameiADH1_ORYSI
AccessioniPrimary (citable) accession number: Q75ZX4
Secondary accession number(s): P20306
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health