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Protein

Chemokine C-C motif receptor-like 2

Gene

CCRL2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-SSC-380108. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
Chemokine C-C motif receptor-like 2
Gene namesi
Name:CCRL2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 13

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence analysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini65 – 7410CytoplasmicSequence analysis
Transmembranei75 – 9521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini96 – 11015ExtracellularSequence analysisAdd
BLAST
Transmembranei111 – 13121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini132 – 14918CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini171 – 20434ExtracellularSequence analysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini226 – 24419CytoplasmicSequence analysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini266 – 28823ExtracellularSequence analysisAdd
BLAST
Transmembranei289 – 30921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini310 – 35041CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Chemokine C-C motif receptor-like 2PRO_0000236801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi109 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ75ZH0.

Expressioni

Gene expression databases

GenevisibleiQ75ZH0. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000024934.

Structurei

3D structure databases

ProteinModelPortaliQ75ZH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKE4. Eukaryota.
ENOG411157E. LUCA.
GeneTreeiENSGT00760000118785.
HOVERGENiHBG106917.
InParanoidiQ75ZH0.
KOiK08373.
OMAiDETFWKH.
OrthoDBiEOG77HDFH.
TreeFamiTF330966.

Family and domain databases

InterProiIPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75ZH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANYTSAPED DYDVFIEDDL SNDERELCSP YDPQALLAQL VPYLFITVFL
60 70 80 90 100
VGLLDNILVV LIMVKYKGLK QVENIYLLNL AVCNLCFLCT LPFWVHMAWH
110 120 130 140 150
EGDPGEPLCK ILLVLYSVGL FSEAFFNVLL TVQRYQKFFQ MRGFFSATRM
160 170 180 190 200
VAGSIFPSAL VWVIAVLVML PELAFYKPQM ENQKYKCFFG RPLFLPADET
210 220 230 240 250
FWKHFLTLKM NILGFLLPLF VFVFCYVRMR RTLKFGERGY DLFKLVFTIM
260 270 280 290 300
VVFLLMWGPY NIALFLSAFN EHFSLHGCES SHNLDRSTLI TKIIATTHCC
310 320 330 340 350
VNPLLYVFFD EAFRKHLYHF CHLCNDTAPQ PTEEPAQGTS REEPCLSTKM
Length:350
Mass (Da):40,592
Last modified:July 5, 2004 - v1
Checksum:i468622AAF673A363
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB119273 mRNA. Translation: BAD12136.1.
AB119274 mRNA. Translation: BAD12137.1.
AP006185 Genomic DNA. Translation: BAD08650.1.
AP006435 Genomic DNA. Translation: BAD08657.1.
RefSeqiNP_001001617.1. NM_001001617.1.
XP_005669514.1. XM_005669457.1.
XP_005669515.1. XM_005669458.2.
XP_013837019.1. XM_013981565.1.
XP_013837020.1. XM_013981566.1.
XP_013837021.1. XM_013981567.1.
XP_013837022.1. XM_013981568.1.
UniGeneiSsc.27201.

Genome annotation databases

EnsembliENSSSCT00000030552; ENSSSCP00000024934; ENSSSCG00000023557.
GeneIDi414370.
KEGGissc:414370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB119273 mRNA. Translation: BAD12136.1.
AB119274 mRNA. Translation: BAD12137.1.
AP006185 Genomic DNA. Translation: BAD08650.1.
AP006435 Genomic DNA. Translation: BAD08657.1.
RefSeqiNP_001001617.1. NM_001001617.1.
XP_005669514.1. XM_005669457.1.
XP_005669515.1. XM_005669458.2.
XP_013837019.1. XM_013981565.1.
XP_013837020.1. XM_013981566.1.
XP_013837021.1. XM_013981567.1.
XP_013837022.1. XM_013981568.1.
UniGeneiSsc.27201.

3D structure databases

ProteinModelPortaliQ75ZH0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000024934.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ75ZH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000030552; ENSSSCP00000024934; ENSSSCG00000023557.
GeneIDi414370.
KEGGissc:414370.

Organism-specific databases

CTDi9034.

Phylogenomic databases

eggNOGiENOG410IKE4. Eukaryota.
ENOG411157E. LUCA.
GeneTreeiENSGT00760000118785.
HOVERGENiHBG106917.
InParanoidiQ75ZH0.
KOiK08373.
OMAiDETFWKH.
OrthoDBiEOG77HDFH.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-SSC-380108. Chemokine receptors bind chemokines.

Gene expression databases

GenevisibleiQ75ZH0. SS.

Family and domain databases

InterProiIPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic structure of eight porcine chemokine receptors and intergene sharing of an exon between CCR1 and XCR1."
    Shinkai H., Morozumi T., Toki D., Eguchi T., Muneta Y., Awata T., Uenishi H.
    Gene 349:55-66(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiCCRL2_PIG
AccessioniPrimary (citable) accession number: Q75ZH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.