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Protein

Testis-specific H1 histone

Gene

H1FNT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1 (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • chromosome condensation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • spermatid nucleus elongation Source: UniProtKB
  • sperm chromatin condensation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, DNA condensation, Spermatogenesis

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32794-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific H1 histone
Alternative name(s):
Haploid germ cell-specific nuclear protein 1
Histone H1t2
Gene namesi
Name:H1FNT
Synonyms:HANP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24893. H1FNT.

Subcellular locationi

  • Nucleus By similarity
  • Chromosome By similarity

  • Note: In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole.By similarity

GO - Cellular componenti

  • nuclear chromatin Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187166.
PharmGKBiPA143485486.

Polymorphism and mutation databases

BioMutaiH1FNT.
DMDMi215274115.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003434141 – 255Testis-specific H1 histoneAdd BLAST255

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ75WM6.
PeptideAtlasiQ75WM6.
PRIDEiQ75WM6.

PTM databases

PhosphoSitePlusiQ75WM6.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Gene expression databases

BgeeiENSG00000187166.
CleanExiHS_H1FNT.
ExpressionAtlasiQ75WM6. baseline and differential.
GenevisibleiQ75WM6. HS.

Organism-specific databases

HPAiHPA046204.

Interactioni

Protein-protein interaction databases

BioGridi131143. 2 interactors.
IntActiQ75WM6. 1 interactor.
STRINGi9606.ENSP00000334805.

Structurei

3D structure databases

ProteinModelPortaliQ75WM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 195Arg-richAdd BLAST67

Sequence similaritiesi

Belongs to the histone H1/H5 family.Curated

Phylogenomic databases

eggNOGiENOG410IX90. Eukaryota.
ENOG4111BIG. LUCA.
GeneTreeiENSGT00730000111596.
HOGENOMiHOG000112840.
InParanoidiQ75WM6.
OMAiKEPPCAR.
OrthoDBiEOG091G0RLA.
PhylomeDBiQ75WM6.
TreeFamiTF338403.

Sequencei

Sequence statusi: Complete.

Q75WM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQALTGEAQ SRWPRRGGSG AMAEAPGPSG ESRGHSATQL PAEKTVGGPS
60 70 80 90 100
RGCSSSVLRV SQLVLQAIST HKGLTLAALK KELRNAGYEV RRKSGRHEAP
110 120 130 140 150
RGQAKATLLR VSGSDAAGYF RVWKVPKPRR KPGRARQEEG TRAPWRTPAA
160 170 180 190 200
PRSSRRRRQP LRKAARKARE VWRRNARAKA KANARARRTR RARPRAKEPP
210 220 230 240 250
CARAKEEAGA TAADEGRGQA VKEDTTPRSG KDKRRSSKPR EEKQEPKKPA

QRTIQ
Length:255
Mass (Da):28,116
Last modified:November 25, 2008 - v3
Checksum:iF5BA8AB6A4D4E912
GO

Sequence cautioni

The sequence BAD13382 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231K → N in AAI18636 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04437184R → G.1 PublicationCorresponds to variant rs2732441dbSNPEnsembl.1
Natural variantiVAR_044372108L → P.1 PublicationCorresponds to variant rs766280749dbSNPEnsembl.1
Natural variantiVAR_044373136R → S.1 PublicationCorresponds to variant rs752698412dbSNPEnsembl.1
Natural variantiVAR_044374174R → Q.2 PublicationsCorresponds to variant rs1471997dbSNPEnsembl.1
Natural variantiVAR_047359195R → Q.Corresponds to variant rs1471997dbSNPEnsembl.1
Natural variantiVAR_044375237S → F.1 PublicationCorresponds to variant rs2291483dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY302593 mRNA. Translation: AAP60022.1.
AC024257 Genomic DNA. No translation available.
BC118635 mRNA. Translation: AAI18636.1.
BC119787 mRNA. Translation: AAI19788.1.
AB121028 mRNA. Translation: BAD13382.2. Different initiation.
AY496854 Genomic DNA. Translation: AAS49492.1.
CCDSiCCDS8762.1.
RefSeqiNP_861453.1. NM_181788.1.
UniGeneiHs.155833.

Genome annotation databases

EnsembliENST00000335017; ENSP00000334805; ENSG00000187166.
GeneIDi341567.
KEGGihsa:341567.
UCSCiuc001rrm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY302593 mRNA. Translation: AAP60022.1.
AC024257 Genomic DNA. No translation available.
BC118635 mRNA. Translation: AAI18636.1.
BC119787 mRNA. Translation: AAI19788.1.
AB121028 mRNA. Translation: BAD13382.2. Different initiation.
AY496854 Genomic DNA. Translation: AAS49492.1.
CCDSiCCDS8762.1.
RefSeqiNP_861453.1. NM_181788.1.
UniGeneiHs.155833.

3D structure databases

ProteinModelPortaliQ75WM6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131143. 2 interactors.
IntActiQ75WM6. 1 interactor.
STRINGi9606.ENSP00000334805.

PTM databases

PhosphoSitePlusiQ75WM6.

Polymorphism and mutation databases

BioMutaiH1FNT.
DMDMi215274115.

Proteomic databases

PaxDbiQ75WM6.
PeptideAtlasiQ75WM6.
PRIDEiQ75WM6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335017; ENSP00000334805; ENSG00000187166.
GeneIDi341567.
KEGGihsa:341567.
UCSCiuc001rrm.3. human.

Organism-specific databases

CTDi341567.
GeneCardsiH1FNT.
HGNCiHGNC:24893. H1FNT.
HPAiHPA046204.
neXtProtiNX_Q75WM6.
OpenTargetsiENSG00000187166.
PharmGKBiPA143485486.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX90. Eukaryota.
ENOG4111BIG. LUCA.
GeneTreeiENSGT00730000111596.
HOGENOMiHOG000112840.
InParanoidiQ75WM6.
OMAiKEPPCAR.
OrthoDBiEOG091G0RLA.
PhylomeDBiQ75WM6.
TreeFamiTF338403.

Enzyme and pathway databases

BioCyciZFISH:G66-32794-MONOMER.

Miscellaneous databases

GenomeRNAii341567.
PROiQ75WM6.

Gene expression databases

BgeeiENSG00000187166.
CleanExiHS_H1FNT.
ExpressionAtlasiQ75WM6. baseline and differential.
GenevisibleiQ75WM6. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiH1FNT_HUMAN
AccessioniPrimary (citable) accession number: Q75WM6
Secondary accession number(s): Q147U8, Q5GKZ5, Q7Z694
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-22 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.