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Q75WH8

- Q75WH8_PSEST

UniProt

Q75WH8 - Q75WH8_PSEST

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Protein
Submitted name: L-rhamnose isomerase
Gene
L-RhI
Organism
Pseudomonas stutzeri (Pseudomonas perfectomarina)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi219 – 2191Cobalt 1
Metal bindingi219 – 2191Copper 1Imported
Metal bindingi219 – 2191Manganese 1Imported
Metal bindingi219 – 2191Zinc 1Imported
Metal bindingi254 – 2541Cobalt 1
Metal bindingi254 – 2541Copper 1Imported
Metal bindingi254 – 2541Manganese 1Imported
Metal bindingi254 – 2541Zinc 1Imported
Metal bindingi257 – 2571Cobalt 2; via tele nitrogen
Metal bindingi257 – 2571Copper 2; via tele nitrogenImported
Metal bindingi257 – 2571Copper 3; via tele nitrogenImported
Metal bindingi257 – 2571Manganese 2; via tele nitrogenImported
Metal bindingi257 – 2571Manganese 3; via tele nitrogenImported
Metal bindingi257 – 2571Zinc 2; via tele nitrogenImported
Metal bindingi257 – 2571Zinc 3; via tele nitrogenImported
Metal bindingi281 – 2811Cobalt 1; via pros nitrogen
Metal bindingi281 – 2811Copper 1; via pros nitrogenImported
Metal bindingi281 – 2811Manganese 1; via pros nitrogenImported
Metal bindingi281 – 2811Zinc 1; via pros nitrogenImported
Metal bindingi289 – 2891Cobalt 2
Metal bindingi289 – 2891Copper 2Imported
Metal bindingi289 – 2891Copper 3Imported
Metal bindingi289 – 2891Manganese 2Imported
Metal bindingi289 – 2891Manganese 3Imported
Metal bindingi289 – 2891Zinc 2Imported
Metal bindingi289 – 2891Zinc 3Imported
Metal bindingi291 – 2911Cobalt 2
Metal bindingi291 – 2911Copper 2Imported
Metal bindingi291 – 2911Copper 3Imported
Metal bindingi291 – 2911Manganese 2Imported
Metal bindingi291 – 2911Manganese 3Imported
Metal bindingi291 – 2911Zinc 2Imported
Metal bindingi291 – 2911Zinc 3Imported
Metal bindingi298 – 2981Manganese 1Imported
Metal bindingi327 – 3271Cobalt 1
Metal bindingi327 – 3271Copper 1Imported
Metal bindingi327 – 3271Manganese 1Imported
Metal bindingi327 – 3271Zinc 1Imported

GO - Molecular functioni

  1. isomerase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Keywords - Ligandi

CobaltImported, CopperImported, ManganeseImported, Metal-bindingImported, ZincImported

Enzyme and pathway databases

BRENDAi5.3.1.14. 421.

Names & Taxonomyi

Protein namesi
Submitted name:
L-rhamnose isomeraseImported
Gene namesi
Name:L-RhIImported
OrganismiPseudomonas stutzeri (Pseudomonas perfectomarina)Imported
Taxonomic identifieri316 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Interactioni

Protein-protein interaction databases

MINTiMINT-7384859.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HCVX-ray2.00A/B/C/D1-430[»]
2I56X-ray1.97A/B/C/D1-430[»]
2I57X-ray1.97A/B/C/D1-430[»]
3ITLX-ray1.70A/B/C/D1-430[»]
3ITOX-ray1.90A/B/C/D1-430[»]
3ITTX-ray1.96A/B/C/D1-430[»]
3ITVX-ray1.60A/B/C/D1-430[»]
3ITXX-ray1.80A/B/C/D1-430[»]
3ITYX-ray1.84A/B/C/D1-430[»]
3IUDX-ray2.44A/B/C/D1-430[»]
3IUHX-ray2.00A/B/C/D1-430[»]
3IUIX-ray2.30A/B/C/D1-430[»]
3M0HX-ray1.58A/B/C/D1-430[»]
3M0LX-ray1.85A/B/C/D1-430[»]
3M0MX-ray1.45A/B/C/D1-430[»]
3M0VX-ray1.79A/B/C/D1-430[»]
3M0XX-ray1.79A/B/C/D1-430[»]
3M0YX-ray1.96A/B/C/D1-430[»]
4GJIX-ray1.70A/B/C/D1-430[»]
4GJJX-ray2.38A/B/C/D1-430[»]
ProteinModelPortaliQ75WH8.
SMRiQ75WH8. Positions 3-430.

Miscellaneous databases

EvolutionaryTraceiQ75WH8.

Family & Domainsi

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
InterProiIPR013451. L_rhamnose_iso.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02629. L_rham_iso_rhiz. 1 hit.

Sequencei

Sequence statusi: Complete.

Q75WH8-1 [UniParc]FASTAAdd to Basket

« Hide

MAEFRIAQDV VARENDRRAS ALKEDYEALG ANLARRGVDI EAVTAKVEKF    50
FVAVPSWGVG TGGTRFARFP GTGEPRGIFD KLDDCAVIQQ LTRATPNVSL 100
HIPWDKADPK ELKARGDALG LGFDAMNSNT FSDAPGQAHS YKYGSLSHTD 150
AATRAQAVEH NLECIEIGKA IGSKALTVWI GDGSNFPGQS NFTRAFERYL 200
SAMAEIYKGL PDDWKLFSEH KMYEPAFYST VVQDWGTNYL IAQTLGPKAQ 250
CLVDLGHHAP NTNIEMIVAR LIQFGKLGGF HFNDSKYGDD DLDAGAIEPY 300
RLFLVFNELV DAEARGVKGF HPAHMIDQSH NVTDPIESLI NSANEIRRAY 350
AQALLVDRAA LSGYQEDNDA LMATETLKRA YRTDVEPILA EARRRTGGAV 400
DPVATYRASG YRARVAAERP ASVAGGGGII 430
Length:430
Mass (Da):46,975
Last modified:July 5, 2004 - v1
Checksum:i2E2FBA87068472A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB121136 Genomic DNA. Translation: BAD14073.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB121136 Genomic DNA. Translation: BAD14073.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HCV X-ray 2.00 A/B/C/D 1-430 [» ]
2I56 X-ray 1.97 A/B/C/D 1-430 [» ]
2I57 X-ray 1.97 A/B/C/D 1-430 [» ]
3ITL X-ray 1.70 A/B/C/D 1-430 [» ]
3ITO X-ray 1.90 A/B/C/D 1-430 [» ]
3ITT X-ray 1.96 A/B/C/D 1-430 [» ]
3ITV X-ray 1.60 A/B/C/D 1-430 [» ]
3ITX X-ray 1.80 A/B/C/D 1-430 [» ]
3ITY X-ray 1.84 A/B/C/D 1-430 [» ]
3IUD X-ray 2.44 A/B/C/D 1-430 [» ]
3IUH X-ray 2.00 A/B/C/D 1-430 [» ]
3IUI X-ray 2.30 A/B/C/D 1-430 [» ]
3M0H X-ray 1.58 A/B/C/D 1-430 [» ]
3M0L X-ray 1.85 A/B/C/D 1-430 [» ]
3M0M X-ray 1.45 A/B/C/D 1-430 [» ]
3M0V X-ray 1.79 A/B/C/D 1-430 [» ]
3M0X X-ray 1.79 A/B/C/D 1-430 [» ]
3M0Y X-ray 1.96 A/B/C/D 1-430 [» ]
4GJI X-ray 1.70 A/B/C/D 1-430 [» ]
4GJJ X-ray 2.38 A/B/C/D 1-430 [» ]
ProteinModelPortali Q75WH8.
SMRi Q75WH8. Positions 3-430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-7384859.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 5.3.1.14. 421.

Miscellaneous databases

EvolutionaryTracei Q75WH8.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
InterProi IPR013451. L_rhamnose_iso.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02629. L_rham_iso_rhiz. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning, nucleotide sequence, and overexpression of the L-rhamnose isomerase gene from Pseudomonas stutzeri in Escherichia coli."
    Leang K., Takada G., Ishimura A., Okita M., Izumori K.
    Appl. Environ. Microbiol. 70:3298-3304(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The structures of L-rhamnose isomerase from Pseudomonas stutzeri in complexes with L-rhamnose and D-allose provide insights into broad substrate specificity."
    Yoshida H., Yamada M., Ohyama Y., Takada G., Izumori K., Kamitori S.
    J. Mol. Biol. 365:1505-1516(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) IN COMPLEX WITH ZINC.
  3. "Catalytic reaction mechanism of Pseudomonas stutzeri L-rhamnose isomerase deduced from X-ray structures."
    Yoshida H., Yamaji M., Ishii T., Izumori K., Kamitori S.
    FEBS J. 277:1045-1057(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH COBALT; COPPER; MANGANESE AND ZINC.
  4. "Elucidation of the role of Ser329 and the C-terminal region in the catalytic activity of Pseudomonas stutzeri L-rhamnose isomerase."
    Yoshida H., Takeda K., Izumori K., Kamitori S.
    Protein Eng. Des. Sel. 23:919-927(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) IN COMPLEX WITH MANGANESE.
  5. "Structure of l-rhamnose isomerase in complex with l-rhamnopyranose demonstrates the sugar-ring opening mechanism and the role of a substrate sub-binding site."
    Yoshida H., Yoshihara A., Teraoka M., Yamashita S., Izumori K., Kamitori S.
    FEBS Open Bio 3:35-40(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH MANGANESE.

Entry informationi

Entry nameiQ75WH8_PSEST
AccessioniPrimary (citable) accession number: Q75WH8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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