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Protein

von Willebrand factor A domain-containing protein 5A

Gene

Vwa5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in may contribute directly to or modify tumorigenesis (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor A domain-containing protein 5A
Alternative name(s):
Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog
Mast cell surface antigen 1
Short name:
Masa-1
Gene namesi
Name:Vwa5a
Synonyms:Loh11cr2a, Masa1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735145. Vwa5a.

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 822822von Willebrand factor A domain-containing protein 5APRO_0000084413Add
BLAST

Proteomic databases

PaxDbiQ75WE7.
PRIDEiQ75WE7.

PTM databases

iPTMnetiQ75WE7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015986.

Structurei

3D structure databases

ProteinModelPortaliQ75WE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 131131VITPROSITE-ProRule annotationAdd
BLAST
Domaini281 – 469189VWFAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 VIT domain.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IG85. Eukaryota.
COG2304. LUCA.
HOGENOMiHOG000006838.
InParanoidiQ75WE7.
OMAiATIDSKH.
OrthoDBiEOG74XS5X.
PhylomeDBiQ75WE7.
TreeFamiTF329720.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF08487. VIT. 1 hit.
PF13768. VWA_3. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75WE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHHWGLITG NKEKVPLKSI SVTLSINDFV AAVAATLHYE NEEKVPIEAM
60 70 80 90 100
FVFPMDEDSA VYSFEALVDG KKIVAELQDK TKAHSKYEEA LSQGHQAYLL
110 120 130 140 150
EEDDYSRDVF SCNVGNLQPG TKVAVTLRYV QELPLESDGA LRYLLPAVLN
160 170 180 190 200
PRYQLSEQSA SSCLNVQKPI VPLEALPYTL SMVATITSQH GIERVQSNCS
210 220 230 240 250
LSPIQYLTDD KTSAQVSLTE GHKFDRDVEL LIYYREVHSP SVAVEKGMQD
260 270 280 290 300
KKRDSLMGAP CAMVSFYPDI PEVNASKVCG EFVFLMDRSG SMQTPMRTEE
310 320 330 340 350
NSQLRIEAAK ETLLLLLKSL PMGCYFNIYG FGSSYEQFFP ESVKYTQETI
360 370 380 390 400
EEAVERVKRL DADLGGTEIL TPLRNIYKTS SIPGHPLQLF VFTDGEVSDT
410 420 430 440 450
YSVIREVKLN SKKHRCFSFG IGQGASTSLI KNIARVSGGT AEFITGKDRM
460 470 480 490 500
QAKALGSLKL ALQCALDDIS LSWELPPGLS VNMLSPEQPT IFRGQRLIIY
510 520 530 540 550
AQLTGPMPQA ESRGAVCLKH TLQGKSLENK VAFSLQPKEN ANFTIHRLAA
560 570 580 590 600
KFLIQTKDLG SHEVSKEEKK DVMNISLQSG VLSSFTAFVA INKELNKPVQ
610 620 630 640 650
GPLAHRVIPR PMIATSTSMF MRSCSRLTGP FKNSRLKRRL CAADYVPYGH
660 670 680 690 700
ESTVYSSMPS PAPIENQGVA DSSNEKSNSQ NEHKAFGENV VLQLIFLQNA
710 720 730 740 750
NGSWKLDENL TKILGTTLED TKAANPSQHG DPSAWATILA VLWLHANGQD
760 770 780 790 800
LKCEWELLER KAVAWLHDHA GRGTTPPPFP SFHLHPREPC LYVLQRTQES
810 820
LWLSQLCCLR TLSLQLILHF QD
Length:822
Mass (Da):91,483
Last modified:July 5, 2004 - v1
Checksum:iE64CD18EC083EA8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB121446 mRNA. Translation: BAC98429.1.
RefSeqiNP_942050.1. NM_198755.1.
XP_006235564.1. XM_006235502.2.
XP_006242901.1. XM_006242839.2.
UniGeneiRn.105620.

Genome annotation databases

GeneIDi301097.
KEGGirno:301097.
UCSCiRGD:735145. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB121446 mRNA. Translation: BAC98429.1.
RefSeqiNP_942050.1. NM_198755.1.
XP_006235564.1. XM_006235502.2.
XP_006242901.1. XM_006242839.2.
UniGeneiRn.105620.

3D structure databases

ProteinModelPortaliQ75WE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015986.

PTM databases

iPTMnetiQ75WE7.

Proteomic databases

PaxDbiQ75WE7.
PRIDEiQ75WE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi301097.
KEGGirno:301097.
UCSCiRGD:735145. rat.

Organism-specific databases

CTDi4013.
RGDi735145. Vwa5a.

Phylogenomic databases

eggNOGiENOG410IG85. Eukaryota.
COG2304. LUCA.
HOGENOMiHOG000006838.
InParanoidiQ75WE7.
OMAiATIDSKH.
OrthoDBiEOG74XS5X.
PhylomeDBiQ75WE7.
TreeFamiTF329720.

Miscellaneous databases

NextBioi648108.
PROiQ75WE7.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF08487. VIT. 1 hit.
PF13768. VWA_3. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mast cell surface antigen-1 (Masa-1); a novel marker for mast cell activation."
    Matsui T., Takagi H., Shiono H., Sakai J., Isaka K., Matsui S., Morishita M., Kondo K., Kato S., Sugiyama H., Shibata M., Atsumi F., Okada T.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiVWA5A_RAT
AccessioniPrimary (citable) accession number: Q75WE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 5, 2004
Last modified: January 20, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.