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Q75WB5

- OPLA_BOVIN

UniProt

Q75WB5 - OPLA_BOVIN

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Protein
5-oxoprolinase
Gene
OPLAH
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.

Catalytic activityi

ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate.

GO - Molecular functioni

  1. 5-oxoprolinase (ATP-hydrolyzing) activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
5-oxoprolinase (EC:3.5.2.9)
Alternative name(s):
5-oxo-L-prolinase
Short name:
5-OPase
Pyroglutamase
Gene namesi
Name:OPLAH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128812885-oxoprolinase
PRO_0000208576Add
BLAST

Proteomic databases

PRIDEiQ75WB5.

Expressioni

Tissue specificityi

Expressed in coronary artery and kidney.1 Publication

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022981.

Structurei

3D structure databases

ProteinModelPortaliQ75WB5.

Family & Domainsi

Sequence similaritiesi

Belongs to the oxoprolinase family.

Phylogenomic databases

eggNOGiCOG0146.
HOGENOMiHOG000047200.
HOVERGENiHBG007870.
InParanoidiQ75WB5.
KOiK01469.

Family and domain databases

InterProiIPR008040. Hydant_A_N.
IPR002821. Hydantoinase_A.
IPR003692. Hydantoinase_B.
[Graphical view]
PfamiPF05378. Hydant_A_N. 1 hit.
PF01968. Hydantoinase_A. 1 hit.
PF02538. Hydantoinase_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75WB5-1 [UniParc]FASTAAdd to Basket

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MGGPEGRFHF AIDRGGTFTD VFAQCPGGHV RVLKLLSEDP ANYVDAPTEG     50
IRRILEQEGG VLLPRDRPLD TSRIASIRMG TTVATNALLE QQGERVALLV 100
TRGFRDLLHV CTQARAXLFD LAVPMPETLY EEVLEVDERV VLYRGXPGAG 150
TPVKGCTGDL LEVQQPVDLG GLRWKLEGLL SRGIRSLAVV LMHSYTWAQH 200
EQQVGALARE LGFTHVSLSS EAMPMVRIVP RGHTACADAY LTPTIQRYVQ 250
GFRRGFQGQL KDVQVLFMRS DGGLAPMDSF SGSRAVLSGP AGGVVGYSAT 300
TYRVEGGQPV IGFDMGGTST DVSRYAGEFE HVFEASTAGV TLQAPQLDIN 350
TVAAGGGSRL FFRSGLFVVG PESAGAHPGP ACYRKGGPVT VTDANLVLGR 400
LLPASFPCIF GPGEDQPLSP EASRKALEAV ATEVNSFLTN GPCPASPLSL 450
EEVAMGFVRV ANEAMCRPIR ALTQARGHDP SAHVLACFGG AGGQHACAIA 500
RALGMDTVHI HRHSGLLSAL GLALADVVHE AQEPCSLPYA PETFAQLDQR 550
LGRLEEQCVE ALRAQGFPRS QISTESFLHL RYQGTDCALM VSAHQHPASA 600
RSPRAGDFGA AFVERYMREF GFIIPERPVV VDDVRVRGTG SSSLRLEDVP 650
KAHSGPPRVD KMTQCYFEGG YQETPVYLLG ELGCGHKLQG PCLIIDSNST 700
ILVEPGCQAE VTETGDIRIS VGAETASVVG TQLDPIHLTI FSHRFMSIAE 750
QMGRILQRTA ISTNIKERLD FSCALFGPDG GLVSNVPHIP VHLGAMQETV 800
QFQIQQLGAD LHPGDVLLSN HPSAGGSHLP DLTVITPVFW PGQTRPVFYV 850
ASRGHHADIG GITPGSMPPH STSLQQEGAV FLSFKLVHGG VFQEEAVTEA 900
LRAPGKIPGC SGTRNLHDNL SDLRAQVAAN QKGIQLVGEL IGQYGLDVVQ 950
AYMGHIQANA ELAVRDMLRA FGTARQARGL PLEVSAEDHM DDGSPIRLRV 1000
QINMSQGSAV FDFSGSGPEV FGNLNAPRAI TLSALIYCLR CLVGRDIPLN 1050
QGCLAPVRVV IPKGSILDPS PDAAVVGGNV LTSQRVVDVI LGAFGACAAS 1100
QGCMNNVTLG NAHMGYYETV AGGAGAGPGW HGRSGVHSHM TNTRITDPEI 1150
LESRYPVILR RFELRLGSGG RGRFRGGDGI IRELLFREEA LLSVLTERRA 1200
FQPYGLMGGE PGARGLNLLI RKDGRTVNLG GKTSVPVYPG DVFCLHTPGG 1250
GGYGDPGDPA PLPGSPLQPL AFPERGSVYE YRRAQEAV 1288
Length:1,288
Mass (Da):137,450
Last modified:July 5, 2004 - v1
Checksum:i61A97ADC5A1A23B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB121737 mRNA. Translation: BAD13433.1.
RefSeqiNP_001001173.1. NM_001001173.1.
UniGeneiBt.3369.

Genome annotation databases

GeneIDi408006.
KEGGibta:408006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB121737 mRNA. Translation: BAD13433.1 .
RefSeqi NP_001001173.1. NM_001001173.1.
UniGenei Bt.3369.

3D structure databases

ProteinModelPortali Q75WB5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000022981.

Proteomic databases

PRIDEi Q75WB5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 408006.
KEGGi bta:408006.

Organism-specific databases

CTDi 26873.

Phylogenomic databases

eggNOGi COG0146.
HOGENOMi HOG000047200.
HOVERGENi HBG007870.
InParanoidi Q75WB5.
KOi K01469.

Miscellaneous databases

NextBioi 20818625.

Family and domain databases

InterProi IPR008040. Hydant_A_N.
IPR002821. Hydantoinase_A.
IPR003692. Hydantoinase_B.
[Graphical view ]
Pfami PF05378. Hydant_A_N. 1 hit.
PF01968. Hydantoinase_A. 1 hit.
PF02538. Hydantoinase_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery."
    Watanabe T., Abe K., Ishikawa H., Iijima Y.
    Biol. Pharm. Bull. 27:288-294(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 3-14, TISSUE SPECIFICITY.
    Tissue: Kidney.

Entry informationi

Entry nameiOPLA_BOVIN
AccessioniPrimary (citable) accession number: Q75WB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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