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Q75WB5

- OPLA_BOVIN

UniProt

Q75WB5 - OPLA_BOVIN

Protein

5-oxoprolinase

Gene

OPLAH

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.

    Catalytic activityi

    ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate.

    GO - Molecular functioni

    1. 5-oxoprolinase (ATP-hydrolyzing) activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-oxoprolinase (EC:3.5.2.9)
    Alternative name(s):
    5-oxo-L-prolinase
    Short name:
    5-OPase
    Pyroglutamase
    Gene namesi
    Name:OPLAH
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 128812885-oxoprolinasePRO_0000208576Add
    BLAST

    Proteomic databases

    PRIDEiQ75WB5.

    Expressioni

    Tissue specificityi

    Expressed in coronary artery and kidney.1 Publication

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000022981.

    Structurei

    3D structure databases

    ProteinModelPortaliQ75WB5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the oxoprolinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0146.
    HOGENOMiHOG000047200.
    HOVERGENiHBG007870.
    InParanoidiQ75WB5.
    KOiK01469.

    Family and domain databases

    InterProiIPR008040. Hydant_A_N.
    IPR002821. Hydantoinase_A.
    IPR003692. Hydantoinase_B.
    [Graphical view]
    PfamiPF05378. Hydant_A_N. 1 hit.
    PF01968. Hydantoinase_A. 1 hit.
    PF02538. Hydantoinase_B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q75WB5-1 [UniParc]FASTAAdd to Basket

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    MGGPEGRFHF AIDRGGTFTD VFAQCPGGHV RVLKLLSEDP ANYVDAPTEG     50
    IRRILEQEGG VLLPRDRPLD TSRIASIRMG TTVATNALLE QQGERVALLV 100
    TRGFRDLLHV CTQARAXLFD LAVPMPETLY EEVLEVDERV VLYRGXPGAG 150
    TPVKGCTGDL LEVQQPVDLG GLRWKLEGLL SRGIRSLAVV LMHSYTWAQH 200
    EQQVGALARE LGFTHVSLSS EAMPMVRIVP RGHTACADAY LTPTIQRYVQ 250
    GFRRGFQGQL KDVQVLFMRS DGGLAPMDSF SGSRAVLSGP AGGVVGYSAT 300
    TYRVEGGQPV IGFDMGGTST DVSRYAGEFE HVFEASTAGV TLQAPQLDIN 350
    TVAAGGGSRL FFRSGLFVVG PESAGAHPGP ACYRKGGPVT VTDANLVLGR 400
    LLPASFPCIF GPGEDQPLSP EASRKALEAV ATEVNSFLTN GPCPASPLSL 450
    EEVAMGFVRV ANEAMCRPIR ALTQARGHDP SAHVLACFGG AGGQHACAIA 500
    RALGMDTVHI HRHSGLLSAL GLALADVVHE AQEPCSLPYA PETFAQLDQR 550
    LGRLEEQCVE ALRAQGFPRS QISTESFLHL RYQGTDCALM VSAHQHPASA 600
    RSPRAGDFGA AFVERYMREF GFIIPERPVV VDDVRVRGTG SSSLRLEDVP 650
    KAHSGPPRVD KMTQCYFEGG YQETPVYLLG ELGCGHKLQG PCLIIDSNST 700
    ILVEPGCQAE VTETGDIRIS VGAETASVVG TQLDPIHLTI FSHRFMSIAE 750
    QMGRILQRTA ISTNIKERLD FSCALFGPDG GLVSNVPHIP VHLGAMQETV 800
    QFQIQQLGAD LHPGDVLLSN HPSAGGSHLP DLTVITPVFW PGQTRPVFYV 850
    ASRGHHADIG GITPGSMPPH STSLQQEGAV FLSFKLVHGG VFQEEAVTEA 900
    LRAPGKIPGC SGTRNLHDNL SDLRAQVAAN QKGIQLVGEL IGQYGLDVVQ 950
    AYMGHIQANA ELAVRDMLRA FGTARQARGL PLEVSAEDHM DDGSPIRLRV 1000
    QINMSQGSAV FDFSGSGPEV FGNLNAPRAI TLSALIYCLR CLVGRDIPLN 1050
    QGCLAPVRVV IPKGSILDPS PDAAVVGGNV LTSQRVVDVI LGAFGACAAS 1100
    QGCMNNVTLG NAHMGYYETV AGGAGAGPGW HGRSGVHSHM TNTRITDPEI 1150
    LESRYPVILR RFELRLGSGG RGRFRGGDGI IRELLFREEA LLSVLTERRA 1200
    FQPYGLMGGE PGARGLNLLI RKDGRTVNLG GKTSVPVYPG DVFCLHTPGG 1250
    GGYGDPGDPA PLPGSPLQPL AFPERGSVYE YRRAQEAV 1288
    Length:1,288
    Mass (Da):137,450
    Last modified:July 5, 2004 - v1
    Checksum:i61A97ADC5A1A23B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB121737 mRNA. Translation: BAD13433.1.
    RefSeqiNP_001001173.1. NM_001001173.1.
    UniGeneiBt.3369.

    Genome annotation databases

    GeneIDi408006.
    KEGGibta:408006.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB121737 mRNA. Translation: BAD13433.1 .
    RefSeqi NP_001001173.1. NM_001001173.1.
    UniGenei Bt.3369.

    3D structure databases

    ProteinModelPortali Q75WB5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000022981.

    Proteomic databases

    PRIDEi Q75WB5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 408006.
    KEGGi bta:408006.

    Organism-specific databases

    CTDi 26873.

    Phylogenomic databases

    eggNOGi COG0146.
    HOGENOMi HOG000047200.
    HOVERGENi HBG007870.
    InParanoidi Q75WB5.
    KOi K01469.

    Miscellaneous databases

    NextBioi 20818625.

    Family and domain databases

    InterProi IPR008040. Hydant_A_N.
    IPR002821. Hydantoinase_A.
    IPR003692. Hydantoinase_B.
    [Graphical view ]
    Pfami PF05378. Hydant_A_N. 1 hit.
    PF01968. Hydantoinase_A. 1 hit.
    PF02538. Hydantoinase_B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery."
      Watanabe T., Abe K., Ishikawa H., Iijima Y.
      Biol. Pharm. Bull. 27:288-294(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 3-14, TISSUE SPECIFICITY.
      Tissue: Kidney.

    Entry informationi

    Entry nameiOPLA_BOVIN
    AccessioniPrimary (citable) accession number: Q75WB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3