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Q75WB5 (OPLA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-oxoprolinase

EC=3.5.2.9
Alternative name(s):
5-oxo-L-prolinase
Short name=5-OPase
Pyroglutamase
Gene names
Name:OPLAH
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length1288 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.

Catalytic activity

ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate.

Subunit structure

Homodimer By similarity.

Tissue specificity

Expressed in coronary artery and kidney. Ref.1

Sequence similarities

Belongs to the oxoprolinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 128812885-oxoprolinase
PRO_0000208576

Sequences

Sequence LengthMass (Da)Tools
Q75WB5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 61A97ADC5A1A23B1

FASTA1,288137,450
        10         20         30         40         50         60 
MGGPEGRFHF AIDRGGTFTD VFAQCPGGHV RVLKLLSEDP ANYVDAPTEG IRRILEQEGG 

        70         80         90        100        110        120 
VLLPRDRPLD TSRIASIRMG TTVATNALLE QQGERVALLV TRGFRDLLHV CTQARAXLFD 

       130        140        150        160        170        180 
LAVPMPETLY EEVLEVDERV VLYRGXPGAG TPVKGCTGDL LEVQQPVDLG GLRWKLEGLL 

       190        200        210        220        230        240 
SRGIRSLAVV LMHSYTWAQH EQQVGALARE LGFTHVSLSS EAMPMVRIVP RGHTACADAY 

       250        260        270        280        290        300 
LTPTIQRYVQ GFRRGFQGQL KDVQVLFMRS DGGLAPMDSF SGSRAVLSGP AGGVVGYSAT 

       310        320        330        340        350        360 
TYRVEGGQPV IGFDMGGTST DVSRYAGEFE HVFEASTAGV TLQAPQLDIN TVAAGGGSRL 

       370        380        390        400        410        420 
FFRSGLFVVG PESAGAHPGP ACYRKGGPVT VTDANLVLGR LLPASFPCIF GPGEDQPLSP 

       430        440        450        460        470        480 
EASRKALEAV ATEVNSFLTN GPCPASPLSL EEVAMGFVRV ANEAMCRPIR ALTQARGHDP 

       490        500        510        520        530        540 
SAHVLACFGG AGGQHACAIA RALGMDTVHI HRHSGLLSAL GLALADVVHE AQEPCSLPYA 

       550        560        570        580        590        600 
PETFAQLDQR LGRLEEQCVE ALRAQGFPRS QISTESFLHL RYQGTDCALM VSAHQHPASA 

       610        620        630        640        650        660 
RSPRAGDFGA AFVERYMREF GFIIPERPVV VDDVRVRGTG SSSLRLEDVP KAHSGPPRVD 

       670        680        690        700        710        720 
KMTQCYFEGG YQETPVYLLG ELGCGHKLQG PCLIIDSNST ILVEPGCQAE VTETGDIRIS 

       730        740        750        760        770        780 
VGAETASVVG TQLDPIHLTI FSHRFMSIAE QMGRILQRTA ISTNIKERLD FSCALFGPDG 

       790        800        810        820        830        840 
GLVSNVPHIP VHLGAMQETV QFQIQQLGAD LHPGDVLLSN HPSAGGSHLP DLTVITPVFW 

       850        860        870        880        890        900 
PGQTRPVFYV ASRGHHADIG GITPGSMPPH STSLQQEGAV FLSFKLVHGG VFQEEAVTEA 

       910        920        930        940        950        960 
LRAPGKIPGC SGTRNLHDNL SDLRAQVAAN QKGIQLVGEL IGQYGLDVVQ AYMGHIQANA 

       970        980        990       1000       1010       1020 
ELAVRDMLRA FGTARQARGL PLEVSAEDHM DDGSPIRLRV QINMSQGSAV FDFSGSGPEV 

      1030       1040       1050       1060       1070       1080 
FGNLNAPRAI TLSALIYCLR CLVGRDIPLN QGCLAPVRVV IPKGSILDPS PDAAVVGGNV 

      1090       1100       1110       1120       1130       1140 
LTSQRVVDVI LGAFGACAAS QGCMNNVTLG NAHMGYYETV AGGAGAGPGW HGRSGVHSHM 

      1150       1160       1170       1180       1190       1200 
TNTRITDPEI LESRYPVILR RFELRLGSGG RGRFRGGDGI IRELLFREEA LLSVLTERRA 

      1210       1220       1230       1240       1250       1260 
FQPYGLMGGE PGARGLNLLI RKDGRTVNLG GKTSVPVYPG DVFCLHTPGG GGYGDPGDPA 

      1270       1280 
PLPGSPLQPL AFPERGSVYE YRRAQEAV 

« Hide

References

[1]"Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery."
Watanabe T., Abe K., Ishikawa H., Iijima Y.
Biol. Pharm. Bull. 27:288-294(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 3-14, TISSUE SPECIFICITY.
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB121737 mRNA. Translation: BAD13433.1.
RefSeqNP_001001173.1. NM_001001173.1.
UniGeneBt.3369.

3D structure databases

ProteinModelPortalQ75WB5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000022981.

Proteomic databases

PRIDEQ75WB5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID408006.
KEGGbta:408006.

Organism-specific databases

CTD26873.

Phylogenomic databases

eggNOGCOG0146.
HOGENOMHOG000047200.
HOVERGENHBG007870.
InParanoidQ75WB5.
KOK01469.

Family and domain databases

InterProIPR008040. Hydant_A_N.
IPR002821. Hydantoinase_A.
IPR003692. Hydantoinase_B.
[Graphical view]
PfamPF05378. Hydant_A_N. 1 hit.
PF01968. Hydantoinase_A. 1 hit.
PF02538. Hydantoinase_B. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20818625.

Entry information

Entry nameOPLA_BOVIN
AccessionPrimary (citable) accession number: Q75WB5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families