Q75W64 (AICDA_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Activation-induced cytidine deaminase
EC=3.5.4.5

Alternative name(s):
Cytidine aminohydrolase

Gene names

Name:	AICDA
Synonyms:	AID

Organism

Canis familiaris (Dog) (Canis lupus familiaris)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3.
Cofactor	Zinc By similarity.
Tissue specificity	Expressed in thymus, lung, spleen, kidney, small intestine, lymph node and tonsil. Ref.1
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Biological process	mRNA processing
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA demethylation Inferred from sequence or structural similarity. Source: UniProtKB mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of methylation-dependent chromatin silencing Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	cytidine deaminase activity Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Activation-induced cytidine deaminase		PRO_0000171686
Sites
	Active site	58	1	Proton donor By similarity
	Metal binding	56	1	Zinc; catalytic By similarity
	Metal binding	87	1	Zinc; catalytic By similarity
	Metal binding	90	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q75W64 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 4BE00D9B9D1550D2	FASTA	198	23,887
	10 20 30 40 50 60 MDSLLMKQRK FLYHFKNVRW AKGRHETYLC YVVKRRDSAT SFSLDFGHLR NKSGCHVELL 70 80 90 100 110 120 FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG YPNLSLRIFA ARLYFCEDRK 130 140 150 160 170 180 AEPEGLRRLH RAGVQIAIMT FKDYFYCWNT FVENREKTFK AWEGLHENSV RLSRQLRRIL 190 LPLYEVDDLR DAFRTLGL

References

[1]

"Molecular cloning of canine activation-induced cytidine deaminase (AID) cDNA and its expression in normal tissues." Ohmori K., Maeda S., Okayama T., Masuda K., Ohno K., Tsujimoto H. J. Vet. Med. Sci. 66:739-741(2004) [PubMed: 15240955] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Lymph node.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB122019 mRNA. Translation: BAD15112.1.
RefSeq	NP_001003380.1. NM_001003380.1.
UniGene	Cfa.4560.
3D structure databases
ProteinModelPortal	Q75W64.
ModBase	Search...
Protein-protein interaction databases
STRING	Q75W64.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCAFT00000022054; ENSCAFP00000020480; ENSCAFG00000013897.
GeneID	442983.
KEGG	cfa:442983.
Organism-specific databases
CTD	57379.
Phylogenomic databases
eggNOG	maNOG07788.
GeneTree	ENSGT00530000062933.
HOVERGEN	HBG050434.
InParanoid	Q75W64.
OMA	CWNTFVE.
OrthoDB	EOG4GQQ5W.
Family and domain databases
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR007904. APOBEC_C. IPR013158. APOBEC_N. IPR016193. Cytidine_deaminase-like. [Graphical view]
KO	K10989.
Pfam	PF05240. APOBEC_C. 1 hit. PF08210. APOBEC_N. 1 hit. [Graphical view]
SUPFAM	SSF53927. Cytidine_deaminase-like. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AICDA_CANFA

Accession

Primary (citable) accession number: Q75W64

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program