Reviewed,
UniProtKB/Swiss-Prot Q75W64 (AICDA_CANFA)
Last modified
January 19, 2010.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Activation-induced cytidine deaminase EC=3.5.4.5 Alternative name(s): Cytidine aminohydrolase | ||||
| Gene names |
| ||||
| Organism | Canis familiaris (Dog) | ||||
| Taxonomic identifier | 9615 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis |
Protein attributes
| Sequence length | 198 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses By similarity. |
| Catalytic activity | Cytidine + H2O = uridine + NH3. |
| Cofactor | Zinc By similarity. |
| Tissue specificity | Expressed in thymus, lung, spleen, kidney, small intestine, lymph node and tonsil. Ref.1 |
| Sequence similarities | Belongs to the cytidine and deoxycytidylate deaminase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | mRNA processing |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| Gene Ontology (GO) | |
| Biological process | mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | cytidine deaminase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 198 | 198 | Activation-induced cytidine deaminase | PRO_0000171686 | |||||
Sites | |||||||||
| Active site | 58 | 1 | Proton donor By similarity | ||||||
| Metal binding | 56 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 87 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 90 | 1 | Zinc; catalytic By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Molecular cloning of canine activation-induced cytidine deaminase (AID) cDNA and its expression in normal tissues." Ohmori K., Maeda S., Okayama T., Masuda K., Ohno K., Tsujimoto H. J. Vet. Med. Sci. 66:739-741(2004) [PubMed: 15240955] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Lymph node. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB122019 mRNA. Translation: BAD15112.1. |
| RefSeq | NP_001003380.1. |
| UniGene | Cfa.4560 |
3D structure databases | |
| SMR | Q75W64. Positions 9-183. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q75W64. |
Genome annotation databases | |
| Ensembl | ENSCAFT00000022054; ENSCAFP00000020480; ENSCAFG00000013897; Canis familiaris. [Genome view] |
| GeneID | 442983. |
| KEGG | cfa:442983. |
Organism-specific databases | |
| CTD | 442983. |
Phylogenomic databases | |
| eggNOG | maNOG07788. |
| HOVERGEN | Q75W64. |
| InParanoid | Q75W64. |
| OMA | CWNTFVE. |
| OrthoDB | EOG934ZRM. |
Enzyme and pathway databases | |
| BRENDA | 3.5.4.5. 463. |
Family and domain databases | |
| InterPro | IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR007904. APOBEC_C. IPR013158. APOBEC_N. IPR016193. Cytidine_deaminase-like. [Graphical view] |
| Pfam | PF05240. APOBEC_C. 1 hit. PF08210. APOBEC_N. 1 hit. [Graphical view] |
| PROSITE | PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AICDA_CANFA | ||||||||
| Accession | Primary (citable) accession number: Q75W64 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


