SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q75W64

- AICDA_CANFA

UniProt

Q75W64 - AICDA_CANFA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Single-stranded DNA cytosine deaminase

Gene
AICDA, AID
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation By similarity.

Catalytic activityi

Cytosine in single-stranded DNA + H2O = uracil in single-stranded DNA + NH3.

Cofactori

Zinc By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi56 – 561Zinc; catalytic By similarity
Active sitei58 – 581Proton donor By similarity
Metal bindingi87 – 871Zinc; catalytic By similarity
Metal bindingi90 – 901Zinc; catalytic By similarity

GO - Molecular functioni

  1. cytidine deaminase activity Source: UniProtKB
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. cellular response to lipopolysaccharide Source: Ensembl
  2. cytidine deamination Source: UniProtKB
  3. DNA demethylation Source: UniProtKB
  4. isotype switching Source: Ensembl
  5. mRNA processing Source: UniProtKB-KW
  6. negative regulation of methylation-dependent chromatin silencing Source: UniProtKB
  7. somatic hypermutation of immunoglobulin genes Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA cytosine deaminase (EC:3.5.4.38)
Alternative name(s):
Activation-induced cytidine deaminase
Cytidine aminohydrolase
Gene namesi
Name:AICDA
Synonyms:AID
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. exosome (RNase complex) Source: Ensembl
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Single-stranded DNA cytosine deaminasePRO_0000171686Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271Phosphothreonine; by PKA By similarity
Modified residuei38 – 381Phosphoserine; by PKA By similarity

Post-translational modificationi

Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity By similarity.

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Expressed in thymus, lung, spleen, kidney, small intestine, lymph node and tonsil.1 Publication

Interactioni

Subunit structurei

Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA. Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1 By similarity. Interacts with SUPT6H, TRIM28 and NCL By similarity.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020480.

Structurei

3D structure databases

ProteinModelPortaliQ75W64.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3030Nuclear localization signal By similarityAdd
BLAST
Regioni2 – 2625Interaction with SUPT6H By similarityAdd
BLAST
Regioni39 – 424Important for interaction with CTNNBL1 By similarity
Regioni183 – 19816Nuclear export signal By similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG39659.
HOGENOMiHOG000033754.
HOVERGENiHBG050434.
InParanoidiQ75W64.
KOiK10989.
OrthoDBiEOG708W0R.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR013158. APOBEC_N.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75W64-1 [UniParc]FASTAAdd to Basket

« Hide

MDSLLMKQRK FLYHFKNVRW AKGRHETYLC YVVKRRDSAT SFSLDFGHLR    50
NKSGCHVELL FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG 100
YPNLSLRIFA ARLYFCEDRK AEPEGLRRLH RAGVQIAIMT FKDYFYCWNT 150
FVENREKTFK AWEGLHENSV RLSRQLRRIL LPLYEVDDLR DAFRTLGL 198
Length:198
Mass (Da):23,887
Last modified:July 5, 2004 - v1
Checksum:i4BE00D9B9D1550D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB122019 mRNA. Translation: BAD15112.1.
RefSeqiNP_001003380.1. NM_001003380.1.
UniGeneiCfa.4560.

Genome annotation databases

GeneIDi442983.
KEGGicfa:442983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB122019 mRNA. Translation: BAD15112.1 .
RefSeqi NP_001003380.1. NM_001003380.1.
UniGenei Cfa.4560.

3D structure databases

ProteinModelPortali Q75W64.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000020480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 442983.
KEGGi cfa:442983.

Organism-specific databases

CTDi 57379.

Phylogenomic databases

eggNOGi NOG39659.
HOGENOMi HOG000033754.
HOVERGENi HBG050434.
InParanoidi Q75W64.
KOi K10989.
OrthoDBi EOG708W0R.

Miscellaneous databases

NextBioi 20831654.

Family and domain databases

InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR013158. APOBEC_N.
IPR016193. Cytidine_deaminase-like.
[Graphical view ]
Pfami PF08210. APOBEC_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53927. SSF53927. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of canine activation-induced cytidine deaminase (AID) cDNA and its expression in normal tissues."
    Ohmori K., Maeda S., Okayama T., Masuda K., Ohno K., Tsujimoto H.
    J. Vet. Med. Sci. 66:739-741(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Lymph node.

Entry informationi

Entry nameiAICDA_CANFA
AccessioniPrimary (citable) accession number: Q75W64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi