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Protein

GRB2-associated and regulator of MAPK protein 2

Gene

GAREM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-associated and regulator of MAPK protein 2
Alternative name(s):
GRB2-associated and regulator of MAPK1-like
Gene namesi
Name:GAREM2
Synonyms:FAM59B, GAREML, KIAA2038
ORF Names:HRIHFB2063
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:27172. GAREM2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671865.

Polymorphism and mutation databases

BioMutaiGAREML.
DMDMi288558847.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874GRB2-associated and regulator of MAPK protein 2PRO_0000340253Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei735 – 7351PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ75VX8.
PaxDbiQ75VX8.
PeptideAtlasiQ75VX8.
PRIDEiQ75VX8.

PTM databases

iPTMnetiQ75VX8.
PhosphoSiteiQ75VX8.

Expressioni

Gene expression databases

BgeeiENSG00000157833.
CleanExiHS_FAM59B.
GenevisibleiQ75VX8. HS.

Interactioni

Protein-protein interaction databases

BioGridi127333. 5 interactions.
IntActiQ75VX8. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ75VX8.
SMRiQ75VX8. Positions 797-872.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini807 – 87165SAMAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni12 – 339328CABITAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi179 – 20527Gly-richAdd
BLAST
Compositional biasi383 – 759377Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the GAREM family.Curated

Phylogenomic databases

eggNOGiENOG410II0U. Eukaryota.
ENOG410XSPW. LUCA.
GeneTreeiENSGT00530000063834.
HOGENOMiHOG000074085.
HOVERGENiHBG060860.
InParanoidiQ75VX8.
OMAiPLFKPSH.
OrthoDBiEOG091G0K06.
PhylomeDBiQ75VX8.
TreeFamiTF329726.

Family and domain databases

InterProiIPR025946. CABIT_dom.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF12736. CABIT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q75VX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKLAAGLAG LRWSMGAFPL DLIVSRCRLP TLACLGPGEY AEGVSERDIL
60 70 80 90 100
LIHSCRQWTT VTAHTLEEGH YVIGPKIDIP LQYPGKFKLL EQARDVREPV
110 120 130 140 150
RYFSSVEEVA SVFPDRIFVM EAITFSVKVV SGEFSEDSEV YNFTLHAGDE
160 170 180 190 200
LTLMGQAEIL CAKTTKERSR FTTLLRKLGR AGALAGVGGG GPASAGAAGG
210 220 230 240 250
TGGGGARPVK GKMPCLICMN HRTNESLSLP FQCQGRFSTR SPLELQMQEG
260 270 280 290 300
EHTVRAIIER VRLPVNVLVP SRPPRNPYDL HPVREGHCYK LVSIISKTVV
310 320 330 340 350
LGLALRREGP APLHFLLLTD TPRFALPQGL LAGDPRVERL VRDSASYCRE
360 370 380 390 400
RFDPDEYSTA VREAPAELAE DCASPRRARL CLPAPRAPGL ARAPGPLAPA
410 420 430 440 450
PAGEGDQEYV SPDWAAAPEP AAPPAEIPYE ELWAHQGPEG LVRPPPGLDL
460 470 480 490 500
ISFGAAGPPR REPEAPPPPV PPKSEAVKEE CRLLNAPPVP PRGGNGSGRL
510 520 530 540 550
SSSPPVPPRF PKLQPVHSPS SSLSYYSSGL QDGAGSRSGS GSPSPDTYSL
560 570 580 590 600
YCYPCTWGDC KVGESSSRPA PGPLPSTTQP SQASRALTEP LSGRAASLLG
610 620 630 640 650
ADTPVKTYHS CPPLFKPSHP QKRFAPFGAL NPFSGPAYPS GPSAALSSGP
660 670 680 690 700
RTTSGPVATS GPAYSPGPAS PGQAYSAAPP SSCAPSSSSS SEWQEPVLEP
710 720 730 740 750
FDPFELGQGS SPEPELLRSQ EPRAVGTPGP GPRLSPLGPS KAFEPEGLVL
760 770 780 790 800
HQVPTPLSPA ALQGPEAGGA LFLTQGRLEG PPASPRDGAT GFGVRDASSW
810 820 830 840 850
QPPADLSALS LEEVSRSLRF IGLSEDVVSF FARERIDGSI FVQLSEDILA
860 870
DDFHLTKLQV KKIMQFIKGW RPKI
Length:874
Mass (Da):92,882
Last modified:February 9, 2010 - v3
Checksum:iC5B7536971763523
GO
Isoform 2 (identifier: Q75VX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     562-694: Missing.

Note: No experimental confirmation available.
Show »
Length:741
Mass (Da):79,710
Checksum:iB674FD8A80F38FA9
GO
Isoform 3 (identifier: Q75VX8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     78-83: DIPLQY → MHRMPD
     562-694: Missing.

Note: No experimental confirmation available.
Show »
Length:664
Mass (Da):71,345
Checksum:i34DEF674129AF41D
GO

Sequence cautioni

The sequence BAC03435 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC99057 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti407 – 4071Q → R in BAC03435 (Ref. 1) Curated
Sequence conflicti473 – 4753KSE → DAW in BAA88120 (PubMed:9853615).Curated
Sequence conflicti733 – 7331R → P in BAC03435 (Ref. 1) Curated
Sequence conflicti819 – 8191R → G in BAC03435 (Ref. 1) Curated
Sequence conflicti864 – 8641M → I in BAC03435 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7777Missing in isoform 3. 1 PublicationVSP_047321Add
BLAST
Alternative sequencei78 – 836DIPLQY → MHRMPD in isoform 3. 1 PublicationVSP_047322
Alternative sequencei562 – 694133Missing in isoform 2 and isoform 3. 2 PublicationsVSP_034201Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB124552 mRNA. Translation: BAC99057.1. Different initiation.
AC011742 Genomic DNA. No translation available.
AK090454 mRNA. Translation: BAC03435.1. Different initiation.
AB015349 mRNA. Translation: BAA88120.1.
CCDSiCCDS54336.1. [Q75VX8-1]
CCDS54337.1. [Q75VX8-3]
RefSeqiNP_001161713.1. NM_001168241.1. [Q75VX8-1]
NP_001177962.1. NM_001191033.1. [Q75VX8-3]
XP_006712014.1. XM_006711951.3. [Q75VX8-2]
UniGeneiHs.187912.

Genome annotation databases

EnsembliENST00000401533; ENSP00000384593; ENSG00000157833. [Q75VX8-1]
ENST00000407684; ENSP00000384581; ENSG00000157833. [Q75VX8-3]
GeneIDi150946.
KEGGihsa:150946.
UCSCiuc002rgw.2. human. [Q75VX8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB124552 mRNA. Translation: BAC99057.1. Different initiation.
AC011742 Genomic DNA. No translation available.
AK090454 mRNA. Translation: BAC03435.1. Different initiation.
AB015349 mRNA. Translation: BAA88120.1.
CCDSiCCDS54336.1. [Q75VX8-1]
CCDS54337.1. [Q75VX8-3]
RefSeqiNP_001161713.1. NM_001168241.1. [Q75VX8-1]
NP_001177962.1. NM_001191033.1. [Q75VX8-3]
XP_006712014.1. XM_006711951.3. [Q75VX8-2]
UniGeneiHs.187912.

3D structure databases

ProteinModelPortaliQ75VX8.
SMRiQ75VX8. Positions 797-872.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127333. 5 interactions.
IntActiQ75VX8. 1 interaction.

PTM databases

iPTMnetiQ75VX8.
PhosphoSiteiQ75VX8.

Polymorphism and mutation databases

BioMutaiGAREML.
DMDMi288558847.

Proteomic databases

EPDiQ75VX8.
PaxDbiQ75VX8.
PeptideAtlasiQ75VX8.
PRIDEiQ75VX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401533; ENSP00000384593; ENSG00000157833. [Q75VX8-1]
ENST00000407684; ENSP00000384581; ENSG00000157833. [Q75VX8-3]
GeneIDi150946.
KEGGihsa:150946.
UCSCiuc002rgw.2. human. [Q75VX8-1]

Organism-specific databases

CTDi150946.
GeneCardsiGAREML.
H-InvDBHIX0001889.
HGNCiHGNC:27172. GAREM2.
neXtProtiNX_Q75VX8.
PharmGKBiPA142671865.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II0U. Eukaryota.
ENOG410XSPW. LUCA.
GeneTreeiENSGT00530000063834.
HOGENOMiHOG000074085.
HOVERGENiHBG060860.
InParanoidiQ75VX8.
OMAiPLFKPSH.
OrthoDBiEOG091G0K06.
PhylomeDBiQ75VX8.
TreeFamiTF329726.

Miscellaneous databases

GenomeRNAii150946.
PROiQ75VX8.

Gene expression databases

BgeeiENSG00000157833.
CleanExiHS_FAM59B.
GenevisibleiQ75VX8. HS.

Family and domain databases

InterProiIPR025946. CABIT_dom.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF12736. CABIT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGARE2_HUMAN
AccessioniPrimary (citable) accession number: Q75VX8
Secondary accession number(s): B5MC97
, B7WNK9, Q8NF27, Q9UIK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 9, 2010
Last modified: September 7, 2016
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.