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Protein

Calcitonin receptor-stimulating peptide 1

Gene

CRSP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stimulates cAMP production in porcine kidney cell line LLC-PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin receptor-stimulating peptide 1
Short name:
CRSP-1
Gene namesi
Name:CRSP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000035307026 – 77By similarityAdd BLAST52
PeptideiPRO_000035307180 – 125Calcitonin receptor-stimulating peptide 1Add BLAST46

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi81 ↔ 86By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ75V95

Expressioni

Gene expression databases

BgeeiENSBTAG00000001516

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001987

Structurei

3D structure databases

SMRiQ75V95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KFWH Eukaryota
ENOG4110SXD LUCA
GeneTreeiENSGT00390000010511
HOVERGENiHBG031362
InParanoidiQ75V95
OrthoDBiEOG091G0RF5
TreeFamiTF333069

Family and domain databases

InterProiView protein in InterPro
IPR021117 Calcitonin-like
IPR021116 Calcitonin/adrenomedullin
IPR018360 Calcitonin_CS
IPR015476 Calcitonin_gene-rel_peptide
IPR001693 Calcitonin_peptide-like
PANTHERiPTHR10505 PTHR10505, 1 hit
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00817 CALCITONINB
SMARTiView protein in SMART
SM00113 CALCITONIN, 1 hit
PROSITEiView protein in PROSITE
PS00258 CALCITONIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q75V95-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFWKFPPFL VLSILVLYQA GMFHAAPFRS VFDGRFDPAT LDEEESRLLL
60 70 80 90 100
AAMVNDYEQM RARESEKAQK TEGSRIQKRA CNTATCMTHR LAGWLSRSGS
110 120
MVRSNLLPTK MGFKIFNGPR RNSWF
Length:125
Mass (Da):14,356
Last modified:July 5, 2004 - v1
Checksum:i39929D89FB61CFD7
GO
Isoform 2 (identifier: Q75V95-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-125: IQKRACNTAT...FNGPRRNSWF → PFLFLYAANQ...MTLGIRSPGS

Show »
Length:149
Mass (Da):17,028
Checksum:iC9CA09D8AA015F3E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03562276 – 125IQKRA…RNSWF → PFLFLYAANQHPEESLQHCH LHDPSPGRLAEQIWEYGEEQ LAADQDGFQDLQWAPQELLV LNSEMTLGIRSPGS in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB125101 mRNA Translation: BAD05115.1
BC118475 mRNA Translation: AAI18476.1
RefSeqiNP_001001149.1, NM_001001149.2 [Q75V95-1]
NP_001128134.1, NM_001134662.1 [Q75V95-2]
UniGeneiBt.29881

Genome annotation databases

EnsembliENSBTAT00000001987; ENSBTAP00000001987; ENSBTAG00000001516 [Q75V95-2]
GeneIDi407218
KEGGibta:407218

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCRSP1_BOVIN
AccessioniPrimary (citable) accession number: Q75V95
Secondary accession number(s): Q17Q98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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