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Protein

Calcitonin receptor-stimulating peptide 1

Gene

CRSP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates cAMP production in porcine kidney cell line LLC-PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor.1 Publication

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-BTA-418555. G alpha (s) signalling events.
R-BTA-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin receptor-stimulating peptide 1
Short name:
CRSP-1
Gene namesi
Name:CRSP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000035307026 – 77By similarityAdd BLAST52
PeptideiPRO_000035307180 – 125Calcitonin receptor-stimulating peptide 1Add BLAST46

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi81 ↔ 86By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ75V95.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001987.

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KFWH. Eukaryota.
ENOG4110SXD. LUCA.
GeneTreeiENSGT00390000010511.
HOVERGENiHBG031362.
InParanoidiQ75V95.
OrthoDBiEOG091G0RF5.
TreeFamiTF333069.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00817. CALCITONINB.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q75V95-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFWKFPPFL VLSILVLYQA GMFHAAPFRS VFDGRFDPAT LDEEESRLLL
60 70 80 90 100
AAMVNDYEQM RARESEKAQK TEGSRIQKRA CNTATCMTHR LAGWLSRSGS
110 120
MVRSNLLPTK MGFKIFNGPR RNSWF
Length:125
Mass (Da):14,356
Last modified:July 5, 2004 - v1
Checksum:i39929D89FB61CFD7
GO
Isoform 2 (identifier: Q75V95-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-125: IQKRACNTAT...FNGPRRNSWF → PFLFLYAANQ...MTLGIRSPGS

Show »
Length:149
Mass (Da):17,028
Checksum:iC9CA09D8AA015F3E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03562276 – 125IQKRA…RNSWF → PFLFLYAANQHPEESLQHCH LHDPSPGRLAEQIWEYGEEQ LAADQDGFQDLQWAPQELLV LNSEMTLGIRSPGS in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB125101 mRNA. Translation: BAD05115.1.
BC118475 mRNA. Translation: AAI18476.1.
RefSeqiNP_001001149.1. NM_001001149.2. [Q75V95-1]
NP_001128134.1. NM_001134662.1. [Q75V95-2]
UniGeneiBt.29881.

Genome annotation databases

EnsembliENSBTAT00000001987; ENSBTAP00000001987; ENSBTAG00000001516. [Q75V95-2]
GeneIDi407218.
KEGGibta:407218.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB125101 mRNA. Translation: BAD05115.1.
BC118475 mRNA. Translation: AAI18476.1.
RefSeqiNP_001001149.1. NM_001001149.2. [Q75V95-1]
NP_001128134.1. NM_001134662.1. [Q75V95-2]
UniGeneiBt.29881.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001987.

Proteomic databases

PaxDbiQ75V95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001987; ENSBTAP00000001987; ENSBTAG00000001516. [Q75V95-2]
GeneIDi407218.
KEGGibta:407218.

Organism-specific databases

CTDi797.

Phylogenomic databases

eggNOGiENOG410KFWH. Eukaryota.
ENOG4110SXD. LUCA.
GeneTreeiENSGT00390000010511.
HOVERGENiHBG031362.
InParanoidiQ75V95.
OrthoDBiEOG091G0RF5.
TreeFamiTF333069.

Enzyme and pathway databases

ReactomeiR-BTA-418555. G alpha (s) signalling events.
R-BTA-419812. Calcitonin-like ligand receptors.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00817. CALCITONINB.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRSP1_BOVIN
AccessioniPrimary (citable) accession number: Q75V95
Secondary accession number(s): Q17Q98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.