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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:GK2395
ORF Names:GKC02
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001172 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003037881 – 448Exodeoxyribonuclease 7 large subunitAdd BLAST448

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

STRINGi235909.GK2395.

Structurei

3D structure databases

ProteinModelPortaliQ75TC0.
SMRiQ75TC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229266.
KOiK03601.
OMAiENAQVRC.
OrthoDBiPOG091H02EK.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q75TC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVKYVTVGA LTKYIKRKFD VDPHLRDLWV KGEISNFKQH SRGHMYFTLK
60 70 80 90 100
DSQGRIAAVM FAGYNQHLPF RPEDGMNVLA RGEISVYEPN GNYQLYVKEM
110 120 130 140 150
QPEGVGSLYL AYEQLKQRLE AEGLFSPVHK KPLPAFPRCI GVVTSPTGAA
160 170 180 190 200
VRDIMTTIRR RYPLAKVILF PALVQGDGAA PSIVRAIERA NSFGGVDVLI
210 220 230 240 250
VGRGGGSIEE LWAFNEEIVA RAIFASKIPI ISAVGHETDF TIADFVADLR
260 270 280 290 300
APTPTAAAEM AAPHVGELAE RLAERKWRLI RAMKEQLAAD KEQLRRLQGS
310 320 330 340 350
YAFRYPKRLY EQKEQQLDAL LERLSRQRER LVDKHRQRLH ELDMRLWRHH
360 370 380 390 400
PAAELERMKE RQKAAANALE KAMRTAVERH RFRFRSNLAR LEALSPLRIM
410 420 430 440
ERGYSLVYNE QGELVKRTNQ LRIGEHLSIQ VQDGRVDCQV TGVEEKHV
Length:448
Mass (Da):51,182
Last modified:July 5, 2004 - v1
Checksum:i1F69A7AFD12987DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126620 Genomic DNA. Translation: BAD18358.1.
BA000043 Genomic DNA. Translation: BAD76680.1.
RefSeqiWP_011231877.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD76680; BAD76680; GK2395.
GeneIDi3183508.
KEGGigka:GK2395.
PATRICi21966231. VBIGeoKau81518_2564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126620 Genomic DNA. Translation: BAD18358.1.
BA000043 Genomic DNA. Translation: BAD76680.1.
RefSeqiWP_011231877.1. NC_006510.1.

3D structure databases

ProteinModelPortaliQ75TC0.
SMRiQ75TC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi235909.GK2395.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD76680; BAD76680; GK2395.
GeneIDi3183508.
KEGGigka:GK2395.
PATRICi21966231. VBIGeoKau81518_2564.

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229266.
KOiK03601.
OMAiENAQVRC.
OrthoDBiPOG091H02EK.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEX7L_GEOKA
AccessioniPrimary (citable) accession number: Q75TC0
Secondary accession number(s): Q5KXA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.