Reviewed,
UniProtKB/Swiss-Prot Q75R65 (JAK2_CHICK)
Last modified
February 9, 2010.
Version 52.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tyrosine-protein kinase JAK2 EC=2.7.10.2 Alternative name(s): Janus kinase 2 Short name=JAK-2 | ||
| Gene names |
| ||
| Organism | Gallus gallus (Chicken) | ||
| Taxonomic identifier | 9031 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 1129 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Tyrosine kinase of the non-receptor type, involved in interleukin-3 and probably interleukin-23 signal transduction By similarity. |
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Subcellular location | Endomembrane system; Peripheral membrane protein By similarity. Note: Wholly intracellular, possibly membrane associated By similarity. |
| Domain | Possesses two phosphotransferase domains. The second one probably contains the catalytic domain By similarity, while the presence of slight differences suggest a different role for domain 1. |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Contains 1 FERM domain. Contains 1 protein kinase domain. Contains 1 SH2 domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Repeat SH2 domain |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase Tyrosine-protein kinase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | tyrosine phosphorylation of STAT protein Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoskeleton Inferred from electronic annotation. Source: InterPro extrinsic to membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW Janus kinase activityInferred from electronic annotation. Source: InterPro non-membrane spanning protein tyrosine kinase activityInferred from electronic annotation. Source: EC protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1129 | 1129 | Tyrosine-protein kinase JAK2 | PRO_0000324095 | |||||
Regions | |||||||||
| Domain | 35 – 378 | 344 | FERM | ||||||
| Domain | 399 – 480 | 82 | SH2; atypical | ||||||
| Domain | 542 – 806 | 265 | Protein kinase 1 | ||||||
| Domain | 846 – 1118 | 273 | Protein kinase 2 | ||||||
| Nucleotide binding | 852 – 860 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 973 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 879 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1004 | 1 | Phosphotyrosine; by autocatalysis By similarity | ||||||
Sequences
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References
| [1] | "molecular cloning and characterization of chicken tyrosine kinase JAK-2." Sayed A.A., Horiuchi H., Furusawa S., Matsuda H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: White leghorn. Tissue: Spleen. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB159042 mRNA. Translation: BAD07298.1. |
| IPI | IPI00584490. |
| RefSeq | NP_001025709.1. |
| UniGene | Gga.954 |
3D structure databases | |
| HSSP | HSSP built from PDB template 2B7A based on UniProtKB O60674. |
| SMR | Q75R65. Positions 395-808, 837-1129. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q75R65. |
Genome annotation databases | |
| Ensembl | ENSGALT00000024235; ENSGALP00000024189; ENSGALG00000015027; Gallus gallus. [Genome view] |
| GeneID | 374199. |
| KEGG | gga:374199. |
Organism-specific databases | |
| CTD | 374199. |
Phylogenomic databases | |
| HOVERGEN | Q75R65. |
Enzyme and pathway databases | |
| BRENDA | 2.7.10.2. 4. |
Family and domain databases | |
| InterPro | IPR019749. Band_41_domain. IPR000299. FERM_domain. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR000980. SH2. IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2. IPR020693. Tyr_kinase_non-rcpt_Jak2. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. IPR009129. Tyr_prot_kinase_JAK2_cons-reg. IPR009127. Tyr_prot_kinase_JAK_cons-reg. [Graphical view] |
| Gene3D | G3DSA:3.30.505.10. SH2. 1 hit. |
| PANTHER | PTHR23256:SF49. Tyr_kinase_non-rcpt_Jak2. 1 hit. PTHR23256. Tyr_prot_kinase. 1 hit. |
| Pfam | PF00017. SH2. 1 hit. [Graphical view] |
| PIRSF | PIRSF000636. TyrPK_Jak. 1 hit. |
| PRINTS | PR01823. JANUSKINASE. PR01825. JANUSKINASE2. |
| SMART | SM00295. B41. 1 hit. SM00252. SH2. 1 hit. SM00219. TyrKc. 2 hits. [Graphical view] |
| PROSITE | PS00660. FERM_1. False negative. PS00661. FERM_2. False negative. PS50057. FERM_3. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 2 hits. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | JAK2_CHICK | ||||||||
| Accession | Primary (citable) accession number: Q75R65 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

Clusters with


