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Q75R65

- JAK2_CHICK

UniProt

Q75R65 - JAK2_CHICK

Protein

Tyrosine-protein kinase JAK2

Gene

JAK2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors, which constitutes an initiating step in signaling for many members of the cytokine receptor superfamily. Following stimulation with erythropoietin (EPO) during erythropoiesis, it is autophosphorylated and activated, leading to its association with erythropoietin receptor (EPOR) and tyrosine phosphorylation of residues in the EPOR cytoplasmic domain. Also involved in promoting the localization of EPOR to the plasma membrane. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Enzyme regulationi

    Regulated by autophosphorylation, can both activate or decrease activity. Heme regulates its activity by enhancing the phosphorylation on Tyr-1004 and Tyr-1005 By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei879 – 8791ATPPROSITE-ProRule annotation
    Active sitei973 – 9731Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi852 – 8609ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. heme binding Source: UniProtKB
    3. histone binding Source: UniProtKB
    4. histone kinase activity (H3-Y41 specific) Source: UniProtKB
    5. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
    6. protein tyrosine kinase activity Source: UniProtKB

    GO - Biological processi

    1. activation of JAK2 kinase activity Source: UniProtKB
    2. cytokine-mediated signaling pathway Source: UniProtKB
    3. erythrocyte differentiation Source: UniProtKB
    4. histone H3-Y41 phosphorylation Source: UniProtKB
    5. JAK-STAT cascade involved in growth hormone signaling pathway Source: UniProtKB
    6. protein autophosphorylation Source: UniProtKB
    7. signal transduction Source: UniProtKB

    Keywords - Molecular functioni

    Chromatin regulator, Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase JAK2 (EC:2.7.10.2)
    Alternative name(s):
    Janus kinase 2
    Short name:
    JAK-2
    Gene namesi
    Name:JAK2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Endomembrane system By similarity; Peripheral membrane protein By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: InterPro
    2. endomembrane system Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB-KW
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11291129Tyrosine-protein kinase JAK2PRO_0000324095Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei117 – 1171Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei865 – 8651Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei963 – 9631Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei969 – 9691Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei1004 – 10041Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei1005 – 10051Phosphotyrosine; by autocatalysisBy similarity

    Post-translational modificationi

    Autophosphorylated, leading to regulate its activity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ75R65.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000037587.

    Structurei

    3D structure databases

    ProteinModelPortaliQ75R65.
    SMRiQ75R65. Positions 837-1129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 378344FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini399 – 48082SH2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini542 – 806265Protein kinase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini846 – 1118273Protein kinase 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Possesses 2 protein kinase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for protein kinase 1 By similarity.By similarity

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation
    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 2 protein kinase domains.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH2 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000049158.
    HOVERGENiHBG006195.
    KOiK04447.
    PhylomeDBiQ75R65.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
    IPR020693. Tyr_kinase_non-rcpt_Jak2.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 2 hits.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
    PRINTSiPR01823. JANUSKINASE.
    PR01825. JANUSKINASE2.
    PR00109. TYRKINASE.
    SMARTiSM00295. B41. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 2 hits.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF55550. SSF55550. 2 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS50057. FERM_3. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q75R65-1 [UniParc]FASTAAdd to Basket

    « Hide

    MACLTMANIE GSATATVHQN GDILGNTSAP KQTEPLLQVY LYYSPGKTGG     50
    DYLQFPAGEY VAEEICIVAC KACGIMPVYH NMFALMSETE RVWYPPNHIF 100
    HVDEATRLKL LYRIRFYFPH WYCNGTSRAC RYGIIRGSES PVLDDLVMSY 150
    LFAQWRKDFL DGWIQMPVTH ETQEECLGMA VLDMMRVAKE KDQTPLAVYN 200
    SVSYKMFLPK CVRAKIQEYH ILTRKRIRYR FRKFIQQFGQ CKATARNLKL 250
    KYLINLETLQ SAFYSEVFEV KEPGGDPSGE ESFATIVITG NGGIQCSRGK 300
    LKNCETLAEQ DLQTYCDFPD IIDVSIKQAS QEGSSERRIV TIHKQDSKNL 350
    EAEFQSLREA LSFVSLIDGY YRLTADAHHY LCKEVAPPSV LENIQSNCHG 400
    PIFMDFAINK LKKAGNQTGF YVLRCSPKDF KKYFLTFAIE RENATDYKHC 450
    LITKNENGEY NLSGTKRSFG NLKDLLTCYQ TETVRSDSII FQFIKCCPPK 500
    PKDKSNLLVF RSNSVSDVPS SPTLQRHNVS QMVFHKIRNE DLIFEESLGQ 550
    GTFTKIFKGI RKEVGDYGQL HQTEVLLKVL DKVHRNYSES FFEAASMMSQ 600
    LSYKHLVLNY GVCVCGEENI LVQEYVKFGS LDTYLKKNKN VINILWKLEV 650
    AKQLALAMHF LEDKGLVHGN VCAKNILLIR EEDRKSGNLP FIKLSDPGIS 700
    ITVLPRDILL ERIPWVPPEC IENPRQLSLA TDKWSFGTTL WEICSGGDKP 750
    LSALDSSRKL QFYEDRHQLP APNWTELANL INNCMDYEPD FRPSFRAIIR 800
    DLNSLFTPDY ELLTENDMLP NIRTGALGFS GAFEDRDPTQ FEERHLKFLQ 850
    QLGKGNFGSV EMCRYDPLQD NTGEVVAVKK LQHSTEEHLR DFEREIEILK 900
    SLQHDNIVKY KGVCYSAGRR NLRLIMEYLP YGSLRDYLQK HKERLDHKKL 950
    LLYASQICKG MEYLGTKRYV HRDLATRNIL VENENRVKIG DFGLTKVLPQ 1000
    DKEYYKVKEP GESPIFWYAP ESLTESKFSV ASDVWSFGVV LYELFTYIEK 1050
    SKSPPAEFMR MIGNDKQGQM IVFHLIELLK NNGRLPRPDG CPDEIYAIMK 1100
    ECWNNNVAQR PTFRDLAQRV DQIRDNMGG 1129
    Length:1,129
    Mass (Da):129,847
    Last modified:July 5, 2004 - v1
    Checksum:i1631EE82D331B9BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB159042 mRNA. Translation: BAD07298.1.
    RefSeqiNP_001025709.1. NM_001030538.1.
    UniGeneiGga.954.

    Genome annotation databases

    GeneIDi374199.
    KEGGigga:374199.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB159042 mRNA. Translation: BAD07298.1 .
    RefSeqi NP_001025709.1. NM_001030538.1.
    UniGenei Gga.954.

    3D structure databases

    ProteinModelPortali Q75R65.
    SMRi Q75R65. Positions 837-1129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000037587.

    Proteomic databases

    PaxDbi Q75R65.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 374199.
    KEGGi gga:374199.

    Organism-specific databases

    CTDi 3717.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000049158.
    HOVERGENi HBG006195.
    KOi K04447.
    PhylomeDBi Q75R65.

    Miscellaneous databases

    NextBioi 20813703.
    PROi Q75R65.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
    IPR020693. Tyr_kinase_non-rcpt_Jak2.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 2 hits.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000636. TyrPK_Jak. 1 hit.
    PRINTSi PR01823. JANUSKINASE.
    PR01825. JANUSKINASE2.
    PR00109. TYRKINASE.
    SMARTi SM00295. B41. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF55550. SSF55550. 2 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS50057. FERM_3. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "molecular cloning and characterization of chicken tyrosine kinase JAK-2."
      Sayed A.A., Horiuchi H., Furusawa S., Matsuda H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: White leghorn.
      Tissue: Spleen.

    Entry informationi

    Entry nameiJAK2_CHICK
    AccessioniPrimary (citable) accession number: Q75R65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3