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Protein

Epithelial cell adhesion molecule

Gene

TACSTD1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SSC-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial cell adhesion molecule
Short name:
Ep-CAM
Alternative name(s):
Tumor-associated calcium signal transducer 1
CD_antigen: CD326
Gene namesi
Name:TACSTD1
Synonyms:EPCAM
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 265ExtracellularSequence analysisAdd BLAST242
Transmembranei266 – 288HelicalSequence analysisAdd BLAST23
Topological domaini289 – 314CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000038018424 – 314Epithelial cell adhesion moleculeAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 46PROSITE-ProRule annotation
Disulfide bondi29 ↔ 59PROSITE-ProRule annotation
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi38 ↔ 48PROSITE-ProRule annotation
Disulfide bondi66 ↔ 99PROSITE-ProRule annotation
Disulfide bondi110 ↔ 116PROSITE-ProRule annotation
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 135PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylation at Asn-198 is crucial for protein stability.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ75QW1
PeptideAtlasiQ75QW1
PRIDEiQ75QW1

Expressioni

Gene expression databases

BgeeiENSSSCG00000008429
GenevisibleiQ75QW1 SS

Interactioni

Subunit structurei

Monomer. Interacts with phosphorylated CLDN7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008996

Structurei

3D structure databases

ProteinModelPortaliQ75QW1
SMRiQ75QW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 135Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Belongs to the EPCAM family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFI6 Eukaryota
ENOG4111M3B LUCA
GeneTreeiENSGT00390000018245
HOGENOMiHOG000074086
InParanoidiQ75QW1
KOiK06737
OMAiREKPYDV
OrthoDBiEOG091G0G1E
TreeFamiTF332767

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00211 TY, 1 hit
SUPFAMiSSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q75QW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPQVLAFG LLLAAATAAV AAAQQGCVCE NYKLTTNCSL NALGQCQCTS
60 70 80 90 100
IGAQNSVICS KLASKCLVMK AEMTGSKAGR RLKPENAIQN NDGLYDPDCD
110 120 130 140 150
ENGLFKAKQC NGTSMCWCVN TAGVRRTDKD SEISCLERVR TYWIIIELKH
160 170 180 190 200
KTREKPYDVT SLQNALKEVI TDRYQLDPKY ITNILYENDI ITIDLVQNSS
210 220 230 240 250
QKTLNEVDIA DVAYYFEKDV KDESLFHSKR MDLRVNGELL DLDPGQTSIY
260 270 280 290 300
YVDEKPPEFS MQGLQAGIIA VIAVVAIAIV AGIIVLIVST KKRRAKYEKA
310
EIKEMGEMHR ELNA
Length:314
Mass (Da):34,833
Last modified:July 5, 2004 - v1
Checksum:i88177EFD6D20D1F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB161197 mRNA Translation: BAD08374.1
RefSeqiNP_999584.1, NM_214419.1
UniGeneiSsc.51858

Genome annotation databases

EnsembliENSSSCT00000009230; ENSSSCP00000008996; ENSSSCG00000008429
ENSSSCT00000061463; ENSSSCP00000045246; ENSSSCG00000008429
GeneIDi403163
KEGGissc:403163

Similar proteinsi

Entry informationi

Entry nameiEPCAM_PIG
AccessioniPrimary (citable) accession number: Q75QW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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