SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q75QN2

- INT8_HUMAN

UniProt

Q75QN2 - INT8_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Integrator complex subunit 8

Gene
INTS8, C8orf52
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. snRNA processing Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 8
Short name:
Int8
Alternative name(s):
Protein kaonashi-1
Gene namesi
Name:INTS8
Synonyms:C8orf52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:26048. INTS8.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. integrator complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 995995Integrator complex subunit 8PRO_0000259553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ75QN2.
PaxDbiQ75QN2.
PRIDEiQ75QN2.

PTM databases

PhosphoSiteiQ75QN2.

Expressioni

Gene expression databases

ArrayExpressiQ75QN2.
BgeeiQ75QN2.
CleanExiHS_INTS8.
GenevestigatoriQ75QN2.

Organism-specific databases

HPAiHPA057299.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.1 Publication

Protein-protein interaction databases

BioGridi120788. 10 interactions.
IntActiQ75QN2. 2 interactions.
MINTiMINT-6777569.
STRINGi9606.ENSP00000343274.

Structurei

3D structure databases

ProteinModelPortaliQ75QN2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati250 – 28839TPR 1Add
BLAST
Repeati320 – 35637TPR 2Add
BLAST
Repeati570 – 60334TPR 3Add
BLAST
Repeati833 – 86634TPR 4Add
BLAST

Sequence similaritiesi

Contains 4 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG82988.
HOVERGENiHBG080418.
InParanoidiQ75QN2.
KOiK13145.
OMAiWPSSIPN.
OrthoDBiEOG77T13W.
PhylomeDBiQ75QN2.
TreeFamiTF324241.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q75QN2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSAEAADREA ATSSRPCTPP QTCWFEFLLE ESLLEKHLRK PCPDPAPVQL    50
IVQFLEQASK PSVNEQNQVQ PPPDNKRNRI LKLLALKVAA HLKWDLDILE 100
KSLSVPVLNM LLNELLCISK VPPGTKHVDM DLATLPPTTA MAVLLYNRWA 150
IRTIVQSSFP VKQAKPGPPQ LSVMNQMQQE KELTENILKV LKEQAADSIL 200
VLEAALKLNK DLYVHTMRTL DLLAMEPGMV NGETESSTAG LKVKTEEMQC 250
QVCYDLGAAY FQQGSTNSAV YENAREKFFR TKELIAEIGS LSLHCTIDEK 300
RLAGYCQACD VLVPSSDSTS QQLTPYSQVH ICLRSGNYQE VIQIFIEDNL 350
TLSLPVQFRQ SVLRELFKKA QQGNEALDEI CFKVCACNTV RDILEGRTIS 400
VQFNQLFLRP NKEKIDFLLE VCSRSVNLEK ASESLKGNMA AFLKNVCLGL 450
EDLQYVFMIS SHELFITLLK DEERKLLVDQ MRKRSPRVNL CIKPVTSFYD 500
IPASASVNIG QLEHQLILSV DPWRIRQILI ELHGMTSERQ FWTVSNKWEV 550
PSVYSGVILG IKDNLTRDLV YILMAKGLHC STVKDFSHAK QLFAACLELV 600
TEFSPKLRQV MLNEMLLLDI HTHEAGTGQA GERPPSDLIS RVRGYLEMRL 650
PDIPLRQVIA EECVAFMLNW RENEYLTLQV PAFLLQSNPY VKLGQLLAAT 700
CKELPGPKES RRTAKDLWEV VVQICSVSSQ HKRGNDGRVS LIKQRESTLG 750
IMYRSELLSF IKKLREPLVL TIILSLFVKL HNVREDIVND ITAEHISIWP 800
SSIPNLQSVD FEAVAITVKE LVRYTLSINP NNHSWLIIQA DIYFATNQYS 850
AALHYYLQAG AVCSDFFNKA VPPDVYTDQV IKRMIKCCSL LNCHTQVAIL 900
CQFLREIDYK TAFKSLQEQN SHDAMDSYYD YIWDVTILEY LTYLHHKRGE 950
TDKRQIAIKA IGQTELNASN PEEVLQLAAQ RRKKKFLQAM AKLYF 995
Length:995
Mass (Da):113,088
Last modified:July 5, 2004 - v1
Checksum:i24D06E11821BD4D5
GO
Isoform 2 (identifier: Q75QN2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     879-895: Missing.

Note: No experimental confirmation available.

Show »
Length:978
Mass (Da):111,116
Checksum:iA1068A253A9BD8C2
GO

Sequence cautioni

The sequence AAH50536.1 differs from that shown. Reason: Frameshift at position 985.
The sequence BAA91238.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA91671.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei879 – 89517Missing in isoform 2. VSP_021469Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti778 – 7781V → A in BAA91238. 1 Publication
Sequence conflicti832 – 8321N → S in CAD98067. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB161944 mRNA. Translation: BAD10863.1.
CH471060 Genomic DNA. Translation: EAW91726.1.
BC050536 mRNA. Translation: AAH50536.1. Frameshift.
BC064915 mRNA. Translation: AAH64915.1.
BC136754 mRNA. Translation: AAI36755.1.
BX538203 mRNA. Translation: CAD98067.1.
AK000537 mRNA. Translation: BAA91238.1. Different initiation.
AK001403 mRNA. Translation: BAA91671.1. Different initiation.
BK005731 mRNA. Translation: DAA05731.1.
CCDSiCCDS34925.1. [Q75QN2-1]
RefSeqiNP_060334.2. NM_017864.3. [Q75QN2-1]
UniGeneiHs.727669.

Genome annotation databases

EnsembliENST00000447247; ENSP00000398203; ENSG00000164941. [Q75QN2-2]
ENST00000523731; ENSP00000430338; ENSG00000164941. [Q75QN2-1]
GeneIDi55656.
KEGGihsa:55656.
UCSCiuc003yha.2. human. [Q75QN2-1]
uc010mba.3. human. [Q75QN2-2]

Polymorphism databases

DMDMi74712892.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB161944 mRNA. Translation: BAD10863.1 .
CH471060 Genomic DNA. Translation: EAW91726.1 .
BC050536 mRNA. Translation: AAH50536.1 . Frameshift.
BC064915 mRNA. Translation: AAH64915.1 .
BC136754 mRNA. Translation: AAI36755.1 .
BX538203 mRNA. Translation: CAD98067.1 .
AK000537 mRNA. Translation: BAA91238.1 . Different initiation.
AK001403 mRNA. Translation: BAA91671.1 . Different initiation.
BK005731 mRNA. Translation: DAA05731.1 .
CCDSi CCDS34925.1. [Q75QN2-1 ]
RefSeqi NP_060334.2. NM_017864.3. [Q75QN2-1 ]
UniGenei Hs.727669.

3D structure databases

ProteinModelPortali Q75QN2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120788. 10 interactions.
IntActi Q75QN2. 2 interactions.
MINTi MINT-6777569.
STRINGi 9606.ENSP00000343274.

PTM databases

PhosphoSitei Q75QN2.

Polymorphism databases

DMDMi 74712892.

Proteomic databases

MaxQBi Q75QN2.
PaxDbi Q75QN2.
PRIDEi Q75QN2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000447247 ; ENSP00000398203 ; ENSG00000164941 . [Q75QN2-2 ]
ENST00000523731 ; ENSP00000430338 ; ENSG00000164941 . [Q75QN2-1 ]
GeneIDi 55656.
KEGGi hsa:55656.
UCSCi uc003yha.2. human. [Q75QN2-1 ]
uc010mba.3. human. [Q75QN2-2 ]

Organism-specific databases

CTDi 55656.
GeneCardsi GC08P095825.
HGNCi HGNC:26048. INTS8.
HPAi HPA057299.
MIMi 611351. gene.
neXtProti NX_Q75QN2.
PharmGKBi PA142672371.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82988.
HOVERGENi HBG080418.
InParanoidi Q75QN2.
KOi K13145.
OMAi WPSSIPN.
OrthoDBi EOG77T13W.
PhylomeDBi Q75QN2.
TreeFami TF324241.

Miscellaneous databases

ChiTaRSi IntS8. human.
GeneWikii INTS8.
GenomeRNAii 55656.
NextBioi 60375.
PROi Q75QN2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q75QN2.
Bgeei Q75QN2.
CleanExi HS_INTS8.
Genevestigatori Q75QN2.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel gene with no significant domain."
    Atsushi S., Asakawa S., Shimizu N.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Testis and Uterus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-995 (ISOFORM 2).
    Tissue: Rectum tumor.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 307-995 (ISOFORM 1).
    Tissue: Carcinoma and Teratocarcinoma.
  6. "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."
    Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N., Shiekhattar R.
    Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE INTEGRATOR COMPLEX.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiINT8_HUMAN
AccessioniPrimary (citable) accession number: Q75QN2
Secondary accession number(s): B2RN92
, Q5RKZ3, Q6P1R5, Q7Z314, Q9NVS6, Q9NWY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi