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Protein

Integrator complex subunit 8

Gene

INTS8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

GO - Biological processi

  • snRNA processing Source: HGNC
  • snRNA transcription by RNA polymerase II Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 8
Short name:
Int8
Alternative name(s):
Protein kaonashi-1
Gene namesi
Name:INTS8
Synonyms:C8orf52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000164941.13
HGNCiHGNC:26048 INTS8
MIMi611351 gene
neXtProtiNX_Q75QN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55656
OpenTargetsiENSG00000164941
PharmGKBiPA142672371

Polymorphism and mutation databases

DMDMi74712892

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595531 – 995Integrator complex subunit 8Add BLAST995

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ75QN2
MaxQBiQ75QN2
PaxDbiQ75QN2
PeptideAtlasiQ75QN2
PRIDEiQ75QN2

PTM databases

iPTMnetiQ75QN2
PhosphoSitePlusiQ75QN2

Expressioni

Gene expression databases

BgeeiENSG00000164941
CleanExiHS_INTS8
ExpressionAtlasiQ75QN2 baseline and differential
GenevisibleiQ75QN2 HS

Organism-specific databases

HPAiHPA057299

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.1 Publication

Protein-protein interaction databases

BioGridi120788, 21 interactors
CORUMiQ75QN2
IntActiQ75QN2, 5 interactors
MINTiQ75QN2
STRINGi9606.ENSP00000430338

Structurei

3D structure databases

ProteinModelPortaliQ75QN2
SMRiQ75QN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati250 – 288TPR 1Add BLAST39
Repeati320 – 356TPR 2Add BLAST37
Repeati570 – 603TPR 3Add BLAST34
Repeati833 – 866TPR 4Add BLAST34

Sequence similaritiesi

Belongs to the Integrator subunit 8 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IFPZ Eukaryota
ENOG410XRVQ LUCA
GeneTreeiENSGT00390000007597
HOVERGENiHBG080418
InParanoidiQ75QN2
KOiK13145
OMAiWPSSIPN
OrthoDBiEOG091G068M
PhylomeDBiQ75QN2
TreeFamiTF324241

Family and domain databases

InterProiView protein in InterPro
IPR038751 Int8
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR13350 PTHR13350, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q75QN2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAEAADREA ATSSRPCTPP QTCWFEFLLE ESLLEKHLRK PCPDPAPVQL
60 70 80 90 100
IVQFLEQASK PSVNEQNQVQ PPPDNKRNRI LKLLALKVAA HLKWDLDILE
110 120 130 140 150
KSLSVPVLNM LLNELLCISK VPPGTKHVDM DLATLPPTTA MAVLLYNRWA
160 170 180 190 200
IRTIVQSSFP VKQAKPGPPQ LSVMNQMQQE KELTENILKV LKEQAADSIL
210 220 230 240 250
VLEAALKLNK DLYVHTMRTL DLLAMEPGMV NGETESSTAG LKVKTEEMQC
260 270 280 290 300
QVCYDLGAAY FQQGSTNSAV YENAREKFFR TKELIAEIGS LSLHCTIDEK
310 320 330 340 350
RLAGYCQACD VLVPSSDSTS QQLTPYSQVH ICLRSGNYQE VIQIFIEDNL
360 370 380 390 400
TLSLPVQFRQ SVLRELFKKA QQGNEALDEI CFKVCACNTV RDILEGRTIS
410 420 430 440 450
VQFNQLFLRP NKEKIDFLLE VCSRSVNLEK ASESLKGNMA AFLKNVCLGL
460 470 480 490 500
EDLQYVFMIS SHELFITLLK DEERKLLVDQ MRKRSPRVNL CIKPVTSFYD
510 520 530 540 550
IPASASVNIG QLEHQLILSV DPWRIRQILI ELHGMTSERQ FWTVSNKWEV
560 570 580 590 600
PSVYSGVILG IKDNLTRDLV YILMAKGLHC STVKDFSHAK QLFAACLELV
610 620 630 640 650
TEFSPKLRQV MLNEMLLLDI HTHEAGTGQA GERPPSDLIS RVRGYLEMRL
660 670 680 690 700
PDIPLRQVIA EECVAFMLNW RENEYLTLQV PAFLLQSNPY VKLGQLLAAT
710 720 730 740 750
CKELPGPKES RRTAKDLWEV VVQICSVSSQ HKRGNDGRVS LIKQRESTLG
760 770 780 790 800
IMYRSELLSF IKKLREPLVL TIILSLFVKL HNVREDIVND ITAEHISIWP
810 820 830 840 850
SSIPNLQSVD FEAVAITVKE LVRYTLSINP NNHSWLIIQA DIYFATNQYS
860 870 880 890 900
AALHYYLQAG AVCSDFFNKA VPPDVYTDQV IKRMIKCCSL LNCHTQVAIL
910 920 930 940 950
CQFLREIDYK TAFKSLQEQN SHDAMDSYYD YIWDVTILEY LTYLHHKRGE
960 970 980 990
TDKRQIAIKA IGQTELNASN PEEVLQLAAQ RRKKKFLQAM AKLYF
Length:995
Mass (Da):113,088
Last modified:July 5, 2004 - v1
Checksum:i24D06E11821BD4D5
GO
Isoform 2 (identifier: Q75QN2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     879-895: Missing.

Note: No experimental confirmation available.
Show »
Length:978
Mass (Da):111,116
Checksum:iA1068A253A9BD8C2
GO

Sequence cautioni

The sequence AAH50536 differs from that shown. Reason: Frameshift at position 985.Curated
The sequence BAA91238 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91671 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti778V → A in BAA91238 (PubMed:14702039).Curated1
Sequence conflicti832N → S in CAD98067 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021469879 – 895Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB161944 mRNA Translation: BAD10863.1
CH471060 Genomic DNA Translation: EAW91726.1
BC050536 mRNA Translation: AAH50536.1 Frameshift.
BC064915 mRNA Translation: AAH64915.1
BC136754 mRNA Translation: AAI36755.1
BX538203 mRNA Translation: CAD98067.1
AK000537 mRNA Translation: BAA91238.1 Different initiation.
AK001403 mRNA Translation: BAA91671.1 Different initiation.
BK005731 mRNA Translation: DAA05731.1
CCDSiCCDS34925.1 [Q75QN2-1]
RefSeqiNP_060334.2, NM_017864.3 [Q75QN2-1]
XP_016869108.1, XM_017013619.1
UniGeneiHs.727669

Genome annotation databases

EnsembliENST00000523731; ENSP00000430338; ENSG00000164941 [Q75QN2-1]
GeneIDi55656
KEGGihsa:55656
UCSCiuc003yhb.5 human [Q75QN2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiINT8_HUMAN
AccessioniPrimary (citable) accession number: Q75QN2
Secondary accession number(s): B2RN92
, Q5RKZ3, Q6P1R5, Q7Z314, Q9NVS6, Q9NWY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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