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Q75Q41

- TOM22_RAT

UniProt

Q75Q41 - TOM22_RAT

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Protein

Mitochondrial import receptor subunit TOM22 homolog

Gene
Tomm22, Tom22
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore.

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. protein transmembrane transporter activity Source: BHF-UCL

GO - Biological processi

  1. protein import into mitochondrial outer membrane Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_199211. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM22 homolog
Short name:
rTOM22
Alternative name(s):
Translocase of outer membrane 22 kDa subunit homolog
Gene namesi
Name:Tomm22
Synonyms:Tom22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi1303260. Tomm22.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 8281Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei83 – 10321Helical; Reviewed predictionAdd
BLAST
Topological domaini104 – 14239Mitochondrial intermembrane Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Ensembl
  3. mitochondrial outer membrane translocase complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi42 – 421E → Q: Inhibits localization to the mitochondrion outer membrane. 1 Publication
Mutagenesisi46 – 461E → P: Inhibits localization to the mitochondrion outer membrane. 1 Publication
Mutagenesisi49 – 491W → P: Inhibits localization to the mitochondrion outer membrane. 1 Publication
Mutagenesisi98 – 981P → A: Inhibits localization to the mitochondrion outer membrane. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 142141Mitochondrial import receptor subunit TOM22 homologPRO_0000383359Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei15 – 151Phosphoserine By similarity
Modified residuei43 – 431Phosphothreonine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ75Q41.
PRIDEiQ75Q41.

Expressioni

Gene expression databases

GenevestigatoriQ75Q41.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOMM40 By similarity. Interacts with PPP2R2B.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019323.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 5010Import sequence; necessary for mitochondrion outer membrane localization and integration in the TOM complex
Regioni83 – 10321TMD; necessary for mitochondrion outer membrane localization and integration in the TOM complexAdd
BLAST
Regioni123 – 14220C-tail signal; necessary for mitochondrion outer membrane localization and integration in the TOM complexAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi110 – 1189Poly-Gln

Domaini

The N-terminal domain (residues 1-60) is important for binding to the unfolded mature imported proteins. Residues (47-69) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 61-80) binds presequence of preproteins By similarity. Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex.

Sequence similaritiesi

Belongs to the Tom22 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG310729.
GeneTreeiENSGT00390000016475.
HOGENOMiHOG000067816.
InParanoidiQ75Q41.
KOiK17769.
OMAiMMPPAPG.
OrthoDBiEOG7KWSKG.
PhylomeDBiQ75Q41.
TreeFamiTF106201.

Family and domain databases

InterProiIPR005683. Tom22.
[Graphical view]
PfamiPF04281. Tom22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q75Q41-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAVAAAGA GEPLSPEELV PKAEAEKAEE DLEEDDDDEL DETLSERLWG    50
LTEMFPERVR SAAGATFDLS LFVAQKMYRF SRAALWIGTT SFMILVLPVV 100
FETEKLQMEQ QQQLQQRQIL LGPNTGLSGG MPGALPPLPG KI 142
Length:142
Mass (Da):15,491
Last modified:July 5, 2004 - v1
Checksum:iC1259302C15CA3AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB162854 mRNA. Translation: BAD11364.1.
CH473950 Genomic DNA. Translation: EDM15790.1.
BC098639 mRNA. Translation: AAH98639.1.
RefSeqiNP_997679.1. NM_212514.2.
UniGeneiRn.3119.

Genome annotation databases

EnsembliENSRNOT00000019323; ENSRNOP00000019323; ENSRNOG00000014058.
GeneIDi300075.
KEGGirno:300075.
UCSCiRGD:1303260. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB162854 mRNA. Translation: BAD11364.1 .
CH473950 Genomic DNA. Translation: EDM15790.1 .
BC098639 mRNA. Translation: AAH98639.1 .
RefSeqi NP_997679.1. NM_212514.2.
UniGenei Rn.3119.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000019323.

Proteomic databases

PaxDbi Q75Q41.
PRIDEi Q75Q41.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000019323 ; ENSRNOP00000019323 ; ENSRNOG00000014058 .
GeneIDi 300075.
KEGGi rno:300075.
UCSCi RGD:1303260. rat.

Organism-specific databases

CTDi 56993.
RGDi 1303260. Tomm22.

Phylogenomic databases

eggNOGi NOG310729.
GeneTreei ENSGT00390000016475.
HOGENOMi HOG000067816.
InParanoidi Q75Q41.
KOi K17769.
OMAi MMPPAPG.
OrthoDBi EOG7KWSKG.
PhylomeDBi Q75Q41.
TreeFami TF106201.

Enzyme and pathway databases

Reactomei REACT_199211. Mitochondrial protein import.

Miscellaneous databases

NextBioi 646277.
PROi Q75Q41.

Gene expression databases

Genevestigatori Q75Q41.

Family and domain databases

InterProi IPR005683. Tom22.
[Graphical view ]
Pfami PF04281. Tom22. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Targeting and assembly of rat mitochondrial translocase of outer membrane 22 (TOM22) into the TOM complex."
    Nakamura Y., Suzuki H., Sakaguchi M., Mihara K.
    J. Biol. Chem. 279:21223-21232(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. "Unfolding-resistant translocase targeting: a novel mechanism for outer mitochondrial membrane localization exemplified by the Bbeta2 regulatory subunit of protein phosphatase 2A."
    Dagda R.K., Barwacz C.A., Cribbs J.T., Strack S.
    J. Biol. Chem. 280:27375-27382(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TOM COMPLEX, INTERACTION WITH PPP2R2B, MUTAGENESIS OF GLU-42; GLU-46; TRP-49 AND PRO-98.

Entry informationi

Entry nameiTOM22_RAT
AccessioniPrimary (citable) accession number: Q75Q41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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