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Protein

Mitochondrial import receptor subunit TOM70

Gene

Tomm70

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor that accelerates the import of all mitochondrial precursor proteins.1 Publication

GO - Biological processi

  • protein transport Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM70
Alternative name(s):
Mitochondrial precursor proteins import receptor
Translocase of outer membrane 70 kDa subunit
Translocase of outer mitochondrial membrane protein 70Imported
Gene namesi
Name:Tomm70Imported
Synonyms:Tomm70a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303049. Tomm70.

Subcellular locationi

  • Mitochondrion outer membrane 1 Publication; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 4140Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Topological domaini63 – 610548CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: RGD
  • mitochondrial outer membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 610609Mitochondrial import receptor subunit TOM70PRO_0000288526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei94 – 941PhosphoserineCombined sources
Modified residuei99 – 991PhosphoserineBy similarity
Modified residuei104 – 1041PhosphoserineCombined sources
Modified residuei107 – 1071PhosphoserineBy similarity
Modified residuei112 – 1121PhosphoserineBy similarity
Modified residuei187 – 1871N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ75Q39.
PRIDEiQ75Q39.

PTM databases

iPTMnetiQ75Q39.
PhosphoSiteiQ75Q39.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with CAPN8 (By similarity).By similarity

Protein-protein interaction databases

BioGridi257743. 1 interaction.
STRINGi10116.ENSRNOP00000002238.

Structurei

3D structure databases

ProteinModelPortaliQ75Q39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati116 – 14934TPR 1Add
BLAST
Repeati155 – 18834TPR 2Add
BLAST
Repeati296 – 32934TPR 3Add
BLAST
Repeati331 – 36434TPR 4Add
BLAST
Repeati369 – 40234TPR 5Add
BLAST
Repeati403 – 43634TPR 6Add
BLAST
Repeati444 – 47734TPR 7Add
BLAST
Repeati478 – 51134TPR 8Add
BLAST
Repeati513 – 54634TPR 9Add
BLAST
Repeati547 – 58034TPR 10Add
BLAST

Sequence similaritiesi

Belongs to the Tom70 family.Curated
Contains 10 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0547. Eukaryota.
ENOG410YVNZ. LUCA.
HOGENOMiHOG000264237.
HOVERGENiHBG062335.
InParanoidiQ75Q39.
KOiK17768.
OrthoDBiEOG7DVD9R.
PhylomeDBiQ75Q39.
TreeFamiTF106203.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13174. TPR_6. 1 hit.
PF13181. TPR_8. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 10 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q75Q39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASKPVEAA MAAAAAPASG NGVGSSGGTA APGSGAGTLP RWHVALAIGA
60 70 80 90 100
PLLLGAGAMY LWSRRRRRRE AGGRGDASGL KRNSERKTPE GRASPALGSG
110 120 130 140 150
PDGSGDSLEM SSLDRAQAAK NKGNKYFKAG KYEQAIQCYT EAISLCPTEK
160 170 180 190 200
NADLSTFYQN RAAAFEQLQK WKEVAQDCTK AVELNPKYVK ALFRRAKAHE
210 220 230 240 250
KLDNKKECLE DVTAVCILEG FQNEQSMLLA DKVLKLLGKE NAKEKYKNRE
260 270 280 290 300
PLMPSPQFIK SYFSSFTDDI ISQPMLKGEK SDEDKDKEGE ALEVKENSGY
310 320 330 340 350
LKAKQYMEEE NYDKIISECS KEIDAQGKYM AEALLLRATF YLLIGSANAA
360 370 380 390 400
KPDLDKVISL KEANVKLRAN ALIKRGTMCM QQQQPMLSTQ DFNMAAEIDP
410 420 430 440 450
MNSDVYHHRG QLKILLDLVE EAVADFDACI RLRPKFALAQ AQKCFALYRQ
460 470 480 490 500
AYTANNSSQV QAAMKGFEEV IKKFPRCAEG YALYAQALTD QQQFGKADEM
510 520 530 540 550
YDKCIDLEPD NATTYVHKGL LQLQWKQDLD KGLELISKAI EIDNKCDFAY
560 570 580 590 600
ETMGTIEVQR GNMEKAIDMF NKAINLAKSE MEMAHLYSLC DAAHAQTEVA
610
KKYGLKPPTL
Length:610
Mass (Da):67,445
Last modified:July 5, 2004 - v1
Checksum:iBE9E4277FE87F6EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162856 mRNA. Translation: BAD11366.1.
BC098640 mRNA. Translation: AAH98640.1.
RefSeqiNP_997684.1. NM_212519.2.
UniGeneiRn.61703.

Genome annotation databases

GeneIDi304017.
KEGGirno:304017.
UCSCiRGD:1303049. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162856 mRNA. Translation: BAD11366.1.
BC098640 mRNA. Translation: AAH98640.1.
RefSeqiNP_997684.1. NM_212519.2.
UniGeneiRn.61703.

3D structure databases

ProteinModelPortaliQ75Q39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi257743. 1 interaction.
STRINGi10116.ENSRNOP00000002238.

PTM databases

iPTMnetiQ75Q39.
PhosphoSiteiQ75Q39.

Proteomic databases

PaxDbiQ75Q39.
PRIDEiQ75Q39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi304017.
KEGGirno:304017.
UCSCiRGD:1303049. rat.

Organism-specific databases

CTDi9868.
RGDi1303049. Tomm70.

Phylogenomic databases

eggNOGiKOG0547. Eukaryota.
ENOG410YVNZ. LUCA.
HOGENOMiHOG000264237.
HOVERGENiHBG062335.
InParanoidiQ75Q39.
KOiK17768.
OrthoDBiEOG7DVD9R.
PhylomeDBiQ75Q39.
TreeFamiTF106203.

Miscellaneous databases

PROiQ75Q39.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13174. TPR_6. 1 hit.
PF13181. TPR_8. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 10 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of rat TOM70 as a receptor of the preprotein translocase of the mitochondrial outer membrane."
    Suzuki H., Maeda M., Mihara K.
    J. Cell Sci. 115:1895-1905(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. Lubec G., Diao W.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 338-356, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  4. "Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS."
    Moser K., White F.M.
    J. Proteome Res. 5:98-104(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND SER-104, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTOM70_RAT
AccessioniPrimary (citable) accession number: Q75Q39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.