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Protein

Aryl hydrocarbon receptor repressor

Gene

Ahrr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor repressor
Short name:
AhR repressor
Short name:
AhRR
Gene namesi
Name:Ahrr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1559857. Ahrr.

Subcellular locationi

  • Cytoplasm
  • Nucleus

  • Note: Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 701701Aryl hydrocarbon receptor repressorPRO_0000333859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki583 – 583Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki660 – 660Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ75NT5.
PRIDEiQ75NT5.

PTM databases

iPTMnetiQ75NT5.
PhosphoSiteiQ75NT5.

Expressioni

Tissue specificityi

Highly expressed in testis and weakly expressed in heart and liver. Highly expressed in small intestine and cecum in a male-dominant sexual dimorphic fashion.2 Publications

Inductioni

Increased after TCDD exposure in liver. Highly increased after TCDD exposure in kidney, spleen and heart. Up-regulated by 3-MC in small intestine.2 Publications

Gene expression databases

GenevisibleiQ75NT5. RN.

Interactioni

Subunit structurei

Interacts with ARNT, ANKRA2, HDAC4 and HDAC5.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019806.

Structurei

3D structure databases

ProteinModelPortaliQ75NT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 7854bHLHPROSITE-ProRule annotationAdd
BLAST
Domaini106 – 17671PASPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni555 – 701147Needed for transcriptional repressionBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3560. Eukaryota.
ENOG410XRZH. LUCA.
GeneTreeiENSGT00800000124106.
HOGENOMiHOG000033866.
HOVERGENiHBG073122.
InParanoidiQ75NT5.
KOiK09094.
OMAiFPTRMHL.
OrthoDBiEOG793BBM.
PhylomeDBiQ75NT5.
TreeFamiTF352074.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75NT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMIPSGECTY AGRKRRKPIQ KRRLTMGTEK SNPSKRHRDR LNTELDHLAS
60 70 80 90 100
LLPFSPDIIS KLDKLSVLRL SVSYLRVKSF FQALQETCVW SAPALSPEDH
110 120 130 140 150
SSRGFPVQEG RLLLESLNGF ALVVSAEGMI FYASATIVDY LGFHQTDVMH
160 170 180 190 200
QNIYDYIHVD DRQDFCRQLH WAMDPPQVVF GQSPHADTDN TVLGKLLRAQ
210 220 230 240 250
EGGKGLPSEY SAFLTRCFIC RVRCLLDSTS GFLTMQFQGK LKFLFGQKKK
260 270 280 290 300
TPSGTALPPR LSLFCIVAPV LPSVTEMKMK SAFLKAKHRA DIVVTMDSRA
310 320 330 340 350
KAVTSLCESE LHPKLNYLAG RSNGENVISL FRGQTDRSHW TRALARSSCL
360 370 380 390 400
CLRGGPDLLD PKGTSGDREE DDQKHILRRS PGARGQREMH KYSYGLETPV
410 420 430 440 450
HLRHLDWSTE QRSQEGTTKL TRQPSKSEPS TCLVPHGSCV PYPGSQGMFS
460 470 480 490 500
ASNMASFRES LDHPTGTYCS QMNRPLPDIH QGQVDPSTCH IPQGSLGSRI
510 520 530 540 550
PLSGMQCFTA RGFSTEDAKL PSLPVNIGTP CNPVLSLEVP IKMENESGSQ
560 570 580 590 600
DIVEASTTSC VWLGTGDMTR RHLVGFPARM HLKTEPDYRQ QVCTPHRGHG
610 620 630 640 650
ILGTNPHSRD TVGSCREHAP LYSAHCTCLS PEPPHHLFMC SHSESQHPSL
660 670 680 690 700
DQDCRAPIVK REPLDSPSWA APGHVTVPRM FPKNASITVI PSKGSDGIFL

P
Length:701
Mass (Da):77,799
Last modified:July 5, 2004 - v1
Checksum:iD80419445C87494E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY367561 mRNA. Translation: AAR15509.1.
AB174900 mRNA. Translation: BAD13341.1.
RefSeqiNP_001019456.1. NM_001024285.1.
UniGeneiRn.145524.

Genome annotation databases

EnsembliENSRNOT00000019806; ENSRNOP00000019806; ENSRNOG00000014721.
GeneIDi498999.
KEGGirno:498999.
UCSCiRGD:1559857. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY367561 mRNA. Translation: AAR15509.1.
AB174900 mRNA. Translation: BAD13341.1.
RefSeqiNP_001019456.1. NM_001024285.1.
UniGeneiRn.145524.

3D structure databases

ProteinModelPortaliQ75NT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019806.

PTM databases

iPTMnetiQ75NT5.
PhosphoSiteiQ75NT5.

Proteomic databases

PaxDbiQ75NT5.
PRIDEiQ75NT5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019806; ENSRNOP00000019806; ENSRNOG00000014721.
GeneIDi498999.
KEGGirno:498999.
UCSCiRGD:1559857. rat.

Organism-specific databases

CTDi57491.
RGDi1559857. Ahrr.

Phylogenomic databases

eggNOGiKOG3560. Eukaryota.
ENOG410XRZH. LUCA.
GeneTreeiENSGT00800000124106.
HOGENOMiHOG000033866.
HOVERGENiHBG073122.
InParanoidiQ75NT5.
KOiK09094.
OMAiFPTRMHL.
OrthoDBiEOG793BBM.
PhylomeDBiQ75NT5.
TreeFamiTF352074.

Miscellaneous databases

PROiQ75NT5.

Gene expression databases

GenevisibleiQ75NT5. RN.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primary structure and inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of aryl hydrocarbon receptor repressor in a TCDD-sensitive and a TCDD-resistant rat strain."
    Korkalainen M., Tuomisto J., Pohjanvirta R.
    Biochem. Biophys. Res. Commun. 315:123-131(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Strain: Long Evans.
  2. "Primary structure and organ-specific expression of the rat aryl hydrocarbon receptor repressor gene."
    Nishihashi H., Kanno Y., Tomuro K., Nakahama T., Inouye Y.
    Biol. Pharm. Bull. 29:640-647(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    Strain: Wistar.
    Tissue: Heart.

Entry informationi

Entry nameiAHRR_RAT
AccessioniPrimary (citable) accession number: Q75NT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.