Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aryl hydrocarbon receptor repressor

Gene

Ahrr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-8937144 Aryl hydrocarbon receptor signalling

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor repressor
Short name:
AhR repressor
Short name:
AhRR
Gene namesi
Name:Ahrr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1559857 Ahrr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003338591 – 701Aryl hydrocarbon receptor repressorAdd BLAST701

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki583Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki660Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ75NT5
PRIDEiQ75NT5

PTM databases

iPTMnetiQ75NT5
PhosphoSitePlusiQ75NT5

Expressioni

Tissue specificityi

Highly expressed in testis and weakly expressed in heart and liver. Highly expressed in small intestine and cecum in a male-dominant sexual dimorphic fashion.2 Publications

Inductioni

Increased after TCDD exposure in liver. Highly increased after TCDD exposure in kidney, spleen and heart. Up-regulated by 3-MC in small intestine.2 Publications

Gene expression databases

BgeeiENSRNOG00000014721
GenevisibleiQ75NT5 RN

Interactioni

Subunit structurei

Interacts with ARNT, ANKRA2, HDAC4 and HDAC5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019806

Structurei

3D structure databases

ProteinModelPortaliQ75NT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 78bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini106 – 176PASPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni555 – 701Needed for transcriptional repressionBy similarityAdd BLAST147

Phylogenomic databases

eggNOGiKOG3560 Eukaryota
ENOG410XRZH LUCA
GeneTreeiENSGT00910000144132
HOGENOMiHOG000033866
HOVERGENiHBG073122
InParanoidiQ75NT5
KOiK09094
OMAiFPTRMHL
OrthoDBiEOG091G16AJ
PhylomeDBiQ75NT5
TreeFamiTF352074

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

Sequencei

Sequence statusi: Complete.

Q75NT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMIPSGECTY AGRKRRKPIQ KRRLTMGTEK SNPSKRHRDR LNTELDHLAS
60 70 80 90 100
LLPFSPDIIS KLDKLSVLRL SVSYLRVKSF FQALQETCVW SAPALSPEDH
110 120 130 140 150
SSRGFPVQEG RLLLESLNGF ALVVSAEGMI FYASATIVDY LGFHQTDVMH
160 170 180 190 200
QNIYDYIHVD DRQDFCRQLH WAMDPPQVVF GQSPHADTDN TVLGKLLRAQ
210 220 230 240 250
EGGKGLPSEY SAFLTRCFIC RVRCLLDSTS GFLTMQFQGK LKFLFGQKKK
260 270 280 290 300
TPSGTALPPR LSLFCIVAPV LPSVTEMKMK SAFLKAKHRA DIVVTMDSRA
310 320 330 340 350
KAVTSLCESE LHPKLNYLAG RSNGENVISL FRGQTDRSHW TRALARSSCL
360 370 380 390 400
CLRGGPDLLD PKGTSGDREE DDQKHILRRS PGARGQREMH KYSYGLETPV
410 420 430 440 450
HLRHLDWSTE QRSQEGTTKL TRQPSKSEPS TCLVPHGSCV PYPGSQGMFS
460 470 480 490 500
ASNMASFRES LDHPTGTYCS QMNRPLPDIH QGQVDPSTCH IPQGSLGSRI
510 520 530 540 550
PLSGMQCFTA RGFSTEDAKL PSLPVNIGTP CNPVLSLEVP IKMENESGSQ
560 570 580 590 600
DIVEASTTSC VWLGTGDMTR RHLVGFPARM HLKTEPDYRQ QVCTPHRGHG
610 620 630 640 650
ILGTNPHSRD TVGSCREHAP LYSAHCTCLS PEPPHHLFMC SHSESQHPSL
660 670 680 690 700
DQDCRAPIVK REPLDSPSWA APGHVTVPRM FPKNASITVI PSKGSDGIFL

P
Length:701
Mass (Da):77,799
Last modified:July 5, 2004 - v1
Checksum:iD80419445C87494E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY367561 mRNA Translation: AAR15509.1
AB174900 mRNA Translation: BAD13341.1
RefSeqiNP_001019456.1, NM_001024285.1
UniGeneiRn.145524

Genome annotation databases

EnsembliENSRNOT00000019806; ENSRNOP00000019806; ENSRNOG00000014721
GeneIDi498999
KEGGirno:498999
UCSCiRGD:1559857 rat

Similar proteinsi

Entry informationi

Entry nameiAHRR_RAT
AccessioniPrimary (citable) accession number: Q75NT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health