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Protein

Zinc transporter ZIP14

Gene

Slc39a14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron.5 Publications

GO - Molecular functioni

  • ferrous iron transmembrane transporter activity Source: MGI
  • zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  • cellular zinc ion homeostasis Source: MGI
  • ferrous iron transmembrane transport Source: GOC
  • ferrous iron transport Source: GOC
  • iron ion transport Source: MGI
  • zinc II ion transmembrane import Source: MGI
  • zinc II ion transmembrane transport Source: MGI
  • zinc II ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP14
Alternative name(s):
Factor for adipocyte differentiation 123
Short name:
FAD-123
Solute carrier family 39 member 14
Zrt- and Irt-like protein 14
Short name:
ZIP-14
Gene namesi
Name:Slc39a14
Synonyms:Fad123, Kiaa0062, Zip14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2384851. Slc39a14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 155127ExtracellularSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Topological domaini177 – 1848CytoplasmicSequence analysis
Transmembranei185 – 20521HelicalSequence analysisAdd
BLAST
Topological domaini206 – 22116ExtracellularSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Topological domaini243 – 349107CytoplasmicSequence analysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence analysisAdd
BLAST
Topological domaini371 – 39424ExtracellularSequence analysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence analysisAdd
BLAST
Topological domaini416 – 4216CytoplasmicSequence analysis
Transmembranei422 – 44221HelicalSequence analysisAdd
BLAST
Topological domaini443 – 45715ExtracellularSequence analysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence analysisAdd
BLAST
Topological domaini479 – 48911CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 489461Zinc transporter ZIP14PRO_0000312195Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)2 Publications
Glycosylationi75 – 751N-linked (GlcNAc...)1 Publication
Glycosylationi85 – 851N-linked (GlcNAc...)1 Publication
Glycosylationi100 – 1001N-linked (GlcNAc...)2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ75N73.
MaxQBiQ75N73.
PaxDbiQ75N73.
PRIDEiQ75N73.

PTM databases

iPTMnetiQ75N73.

Expressioni

Tissue specificityi

Highly and transiently expressed during the early stage of adipocyte differentiation. Strongly expressed in liver, preadipocyte, duodenum and jejunum, moderately in brain, heart, skeletal muscle, spleen, pancreas, kidney and white adipose cells. Expression is almost undetectable in lung, testis and brown adipose cells.4 Publications

Inductioni

Up-regulated by IL6.3 Publications

Gene expression databases

BgeeiQ75N73.
ExpressionAtlasiQ75N73. baseline and differential.
GenevisibleiQ75N73. MM.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

IntActiQ75N73. 2 interactions.
MINTiMINT-4119856.
STRINGi10090.ENSMUSP00000022688.

Structurei

3D structure databases

ProteinModelPortaliQ75N73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi248 – 2558HHHGHXHX-motif
Motifi373 – 3786XEXPHE-motif

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000070225.
HOVERGENiHBG108450.
InParanoidiQ75N73.
KOiK14720.
OrthoDBiEOG73BVD2.
PhylomeDBiQ75N73.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q75N73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRLHPALPS CLLLVLFGIW RTAPQTHASS AGLPPLSATS FLEDLMDRYG
60 70 80 90 100
KNDSLTLTQL KSLLDHLHVG VGRDNVSQPK EGPRNLSTCF SSGDLFAAHN
110 120 130 140 150
LSERSQIGAS EFQEFCPTIL QQLDSQACTS ENQKSEENEQ TEEGKPSAIE
160 170 180 190 200
VWGYGFLCVT VISLCSLMGA SVVPFMKKTF YKRLLLYFIA LAIGTLYSNA
210 220 230 240 250
LFQLIPEAFG FNPQDNYVSK SAVVFGGFYL FFFTEKILKM LLKQKNEHHH
260 270 280 290 300
GHNHFTSETL PSKKDQEEGV TEKLQNGDLD HMIPQHCNSE LDGKAPGTDE
310 320 330 340 350
KVIVNSMSVQ DLQASQSACY WLKGVRYSDI GTLAWMITLS DGLHNFIDGL
360 370 380 390 400
AIGASFTVSV FQGISTSVAI LCEEFPHELG DFVILLNAGM SIQQALFFNF
410 420 430 440 450
LSACCCYLGL AFGILAGSHF SANWIFALAG GMFLYIALAD MFPEMNEVCQ
460 470 480
EDEKNDSFLV PFVIQNLGLL TGFSIMLVLT MYSGQIQIG
Length:489
Mass (Da):53,962
Last modified:July 5, 2004 - v1
Checksum:iDB1F6F971A74D6FF
GO
Isoform 2 (identifier: Q75N73-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-328: Missing.

Note: No experimental confirmation available.
Show »
Length:368
Mass (Da):40,259
Checksum:i98B2A264F04EDAC4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541Y → F in AAH21530 (PubMed:15489334).Curated
Sequence conflicti158 – 18629CVTVI…KRLLL → SVSLINLASLLGVLVLPCTE KAFFSRVLT in AAH21530 (PubMed:15489334).CuratedAdd
BLAST
Sequence conflicti192 – 1921A → S in AAH21530 (PubMed:15489334).Curated
Sequence conflicti197 – 1971Y → L in AAH21530 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei208 – 328121Missing in isoform 2. 1 PublicationVSP_029729Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB177995 mRNA. Translation: BAD16742.1.
BC021530 mRNA. Translation: AAH21530.1.
AK122197 Transcribed RNA. Translation: BAC65479.2.
CCDSiCCDS36969.1. [Q75N73-1]
RefSeqiNP_001128623.1. NM_001135151.1.
NP_001128624.1. NM_001135152.1.
NP_659057.2. NM_144808.4. [Q75N73-1]
XP_006518851.1. XM_006518788.2.
XP_006518852.1. XM_006518789.2.
UniGeneiMm.270647.

Genome annotation databases

EnsembliENSMUST00000068044; ENSMUSP00000066108; ENSMUSG00000022094. [Q75N73-1]
GeneIDi213053.
KEGGimmu:213053.
UCSCiuc007uns.1. mouse. [Q75N73-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB177995 mRNA. Translation: BAD16742.1.
BC021530 mRNA. Translation: AAH21530.1.
AK122197 Transcribed RNA. Translation: BAC65479.2.
CCDSiCCDS36969.1. [Q75N73-1]
RefSeqiNP_001128623.1. NM_001135151.1.
NP_001128624.1. NM_001135152.1.
NP_659057.2. NM_144808.4. [Q75N73-1]
XP_006518851.1. XM_006518788.2.
XP_006518852.1. XM_006518789.2.
UniGeneiMm.270647.

3D structure databases

ProteinModelPortaliQ75N73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ75N73. 2 interactions.
MINTiMINT-4119856.
STRINGi10090.ENSMUSP00000022688.

PTM databases

iPTMnetiQ75N73.

Proteomic databases

EPDiQ75N73.
MaxQBiQ75N73.
PaxDbiQ75N73.
PRIDEiQ75N73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068044; ENSMUSP00000066108; ENSMUSG00000022094. [Q75N73-1]
GeneIDi213053.
KEGGimmu:213053.
UCSCiuc007uns.1. mouse. [Q75N73-1]

Organism-specific databases

CTDi23516.
MGIiMGI:2384851. Slc39a14.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000070225.
HOVERGENiHBG108450.
InParanoidiQ75N73.
KOiK14720.
OrthoDBiEOG73BVD2.
PhylomeDBiQ75N73.
TreeFamiTF318470.

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

PROiQ75N73.
SOURCEiSearch...

Gene expression databases

BgeeiQ75N73.
ExpressionAtlasiQ75N73. baseline and differential.
GenevisibleiQ75N73. MM.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SLC39A14, a LZT protein, is induced in adipogenesis and transports zinc."
    Tominaga K., Kagata T., Johmura Y., Hishida T., Nishizuka M., Imagawa M.
    FEBS J. 272:1590-1599(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-489 (ISOFORM 2).
    Tissue: Brain.
  4. "Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response."
    Liuzzi J.P., Lichten L.A., Rivera S., Blanchard R.K., Aydemir T.B., Knutson M.D., Ganz T., Cousins R.J.
    Proc. Natl. Acad. Sci. U.S.A. 102:6843-6848(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY IL6, SUBCELLULAR LOCATION, FUNCTION, TISSUE SPECIFICITY.
  5. "Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells."
    Liuzzi J.P., Aydemir F., Nam H., Knutson M.D., Cousins R.J.
    Proc. Natl. Acad. Sci. U.S.A. 103:13612-13617(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY IL6, SUBCELLULAR LOCATION, FUNCTION, TISSUE SPECIFICITY.
  6. "Induction of metallothionein by manganese is completely dependent on interleukin-6 production."
    Kobayashi K., Kuroda J., Shibata N., Hasegawa T., Seko Y., Satoh M., Tohyama C., Takano H., Imura N., Sakabe K., Fujishiro H., Himeno S.
    J. Pharmacol. Exp. Ther. 320:721-727(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY IL6, TISSUE SPECIFICITY, FUNCTION.
  7. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-52 AND ASN-100.
    Tissue: Myoblast.
  8. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-52; ASN-75; ASN-85 AND ASN-100.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver and Pancreas.
  10. "Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron."
    Pinilla-Tenas J.J., Sparkman B.K., Shawki A., Illing A.C., Mitchell C.J., Zhao N., Liuzzi J.P., Cousins R.J., Knutson M.D., Mackenzie B.
    Am. J. Physiol. 301:C862-C871(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiS39AE_MOUSE
AccessioniPrimary (citable) accession number: Q75N73
Secondary accession number(s): Q80U85, Q8VDL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.