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Protein
Submitted name:

IL6 protein

Gene

IL6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
IL6 proteinImported
Submitted name:
Interleukin 6 (Interferon, beta 2)Imported
Submitted name:
Interleukin 6 (Interferon, beta 2), isoform CRA_aImported
Submitted name:
Uncharacterized protein IL6Imported
Gene namesi
Name:IL6Imported
ORF Names:hCG_38231Imported, tcag7.131Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000136244.11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_501110164528 – 212Sequence analysisAdd BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 78UniRule annotation
Disulfide bondi101 ↔ 111UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

MaxQBiQ75MH2.

Expressioni

Gene expression databases

BgeeiENSG00000136244.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ75MH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IW11. Eukaryota.
ENOG4112BXV. LUCA.
HOVERGENiHBG000471.
KOiK05405.
OMAiLQAQNQW.
OrthoDBiEOG091G0NW5.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
PfamiView protein in Pfam
PF00489. IL6. 1 hit.
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiView protein in SMART
SM00126. IL6. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00254. INTERLEUKIN_6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q75MH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS
60 70 80 90 100
ERIDKQIRYI LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG
110 120 130 140 150
CFQSGFNEET CLVKIITGLL EFEVYLEYLQ NRFESSEEQA RAVQMSTKVL
160 170 180 190 200
IQFLQKKAKN LDAITTPDPT TNASLLTKLQ AQNQWLQDMT THLILRSFKE
210
FLQSSLRALR QM
Length:212
Mass (Da):23,718
Last modified:May 10, 2005 - v1
Checksum:i1F1ED1FE1B734079
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei212Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073072 Genomic DNA. Translation: AAS07539.1.
BT019748 mRNA. Translation: AAV38553.1.
BT019749 mRNA. Translation: AAV38554.1.
CR450296 mRNA. Translation: CAG29292.1.
CH236948 Genomic DNA. Translation: EAL24265.1.
CH471073 Genomic DNA. Translation: EAW93756.1.
CH471073 Genomic DNA. Translation: EAW93758.1.
RefSeqiNP_000591.1. NM_000600.4.
XP_011513692.1. XM_011515390.2.
UniGeneiHs.654458.

Genome annotation databases

GeneIDi3569.
KEGGihsa:3569.
UCSCiuc003svj.5. human.

Similar proteinsi

Entry informationi

Entry nameiQ75MH2_HUMAN
AccessioniPrimary (citable) accession number: Q75MH2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 22, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.