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Protein
Submitted name:

IL6 protein

Gene

IL6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
IL6 proteinImported
Submitted name:
Interleukin 6 (Interferon, beta 2)Imported
Submitted name:
Interleukin 6 (Interferon, beta 2), isoform CRA_aImported
Submitted name:
Putative uncharacterized protein IL6Imported
Gene namesi
Name:IL6Imported
ORF Names:hCG_38231Imported, tcag7.131Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500878315028 – 212Sequence analysisAdd BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 78UniRule annotation
Disulfide bondi101 ↔ 111UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000136244.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000258743.

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IW11. Eukaryota.
ENOG4112BXV. LUCA.
HOVERGENiHBG000471.
KOiK05405.
OMAiFNQETCL.
OrthoDBiEOG091G0NW5.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75MH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS
60 70 80 90 100
ERIDKQIRYI LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG
110 120 130 140 150
CFQSGFNEET CLVKIITGLL EFEVYLEYLQ NRFESSEEQA RAVQMSTKVL
160 170 180 190 200
IQFLQKKAKN LDAITTPDPT TNASLLTKLQ AQNQWLQDMT THLILRSFKE
210
FLQSSLRALR QM
Length:212
Mass (Da):23,718
Last modified:May 10, 2005 - v1
Checksum:i1F1ED1FE1B734079
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei212Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073072 Genomic DNA. Translation: AAS07539.1.
BT019748 mRNA. Translation: AAV38553.1.
BT019749 mRNA. Translation: AAV38554.1.
CR450296 mRNA. Translation: CAG29292.1.
CH236948 Genomic DNA. Translation: EAL24265.1.
CH471073 Genomic DNA. Translation: EAW93756.1.
CH471073 Genomic DNA. Translation: EAW93758.1.
RefSeqiNP_000591.1. NM_000600.4.
XP_011513692.1. XM_011515390.2.
UniGeneiHs.654458.

Genome annotation databases

GeneIDi3569.
KEGGihsa:3569.
UCSCiuc003svj.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073072 Genomic DNA. Translation: AAS07539.1.
BT019748 mRNA. Translation: AAV38553.1.
BT019749 mRNA. Translation: AAV38554.1.
CR450296 mRNA. Translation: CAG29292.1.
CH236948 Genomic DNA. Translation: EAL24265.1.
CH471073 Genomic DNA. Translation: EAW93756.1.
CH471073 Genomic DNA. Translation: EAW93758.1.
RefSeqiNP_000591.1. NM_000600.4.
XP_011513692.1. XM_011515390.2.
UniGeneiHs.654458.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000258743.

Protocols and materials databases

DNASUi3569.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3569.
KEGGihsa:3569.
UCSCiuc003svj.5. human.

Organism-specific databases

CTDi3569.
PharmGKBiPA198.

Phylogenomic databases

eggNOGiENOG410IW11. Eukaryota.
ENOG4112BXV. LUCA.
HOVERGENiHBG000471.
KOiK05405.
OMAiFNQETCL.
OrthoDBiEOG091G0NW5.

Miscellaneous databases

ChiTaRSiIL6. human.
GenomeRNAii3569.

Gene expression databases

BgeeiENSG00000136244.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ75MH2_HUMAN
AccessioniPrimary (citable) accession number: Q75MH2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.