ID   Q75MF0_HUMAN            Unreviewed;       570 AA.
AC   Q75MF0;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 83.
DE   RecName: Full=Dipeptidyl aminopeptidase-like protein 6 {ECO:0000256|ARBA:ARBA00040948};
DE   AltName: Full=Dipeptidyl peptidase 6 {ECO:0000256|ARBA:ARBA00042016};
DE   AltName: Full=Dipeptidyl peptidase VI {ECO:0000256|ARBA:ARBA00041991};
DE   Flags: Fragment;
GN   Name=DPP6 {ECO:0000313|EMBL:AAS07493.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAS07493.1};
RN   [1] {ECO:0000313|EMBL:AAS07493.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Waterston R.;
RL   Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAS07493.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [3] {ECO:0000313|EMBL:AAS07493.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wilson R.;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AC073336; AAS07493.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q75MF0; -.
DR   ESTHER; human-DPP6; DPP4N_Peptidase_S9.
DR   MEROPS; S09.973; -.
DR   PeptideAtlas; Q75MF0; -.
DR   ChiTaRS; DPP6; human.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF20; DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   4: Predicted;
FT   DOMAIN          1..266
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          347..553
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAS07493.1"
SQ   SEQUENCE   570 AA;  64982 MW;  C71E68AE898744B6 CRC64;
     EILKTHIAHW WSPDGTRLAY AAINDSRVPI MELPTYTGSI YPTVKPYHYP KAGSENPSIS
     LHVIGLNGPT HDLEMMPPDD PRMREYYITM VKWATSTKVA VTWLNRAQNV SILTLCDATT
     GVCTKKHEDE SEAWLHRQNE EPVFSKDGRK FFFIRAIPQG GRGKFYHITV SSSQPNSSND
     NIQSITSGDW DVTKILAYDE KGNKIYFLST EDLPRRRQLY SANTVGNFNR QCLSCDLVEN
     CTYFSASFSH SMDFFLLKCE GPGVPMVTVH NTTDKKKMFD LETNEHVKKA INDRQMPKVE
     YRDIEIDDYN LPMQILKPAT FTDTTHYPLL LVVDGTPGSQ SVAEKFEVSW ETVMVSSHGA
     VVVKCDGRGS GFQGTKLLHE VRRRLGLLEE KDQMEAVRTM LKEQYIDRTR VAVFGKDYGG
     YLSTYILPAK GENQGQTFTC GSALSPITDF KLYASAFSER YLGLHGLDNR AYEMTKVAHR
     VSALEEQQFL IIHPTADEKI HFQHTAELIT QLIRGKANYS LQIYPDESHY FTSSSLKQHL
     YRSIINFFVE CFRIQDKLLT VTAKEDEEED
//