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Protein

Putative FK506-binding protein 9-like protein

Gene

FKBP9P1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi118 – 1292PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31022-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative FK506-binding protein 9-like protein
Alternative name(s):
FK506-binding protein 9-like protein pseudogene
Gene namesi
Name:FKBP9P1
Synonyms:FKBP9L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:23568. FKBP9P1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74758923.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094781 – 142Putative FK506-binding protein 9-like proteinAdd BLAST142

Proteomic databases

MaxQBiQ75LS8.
PaxDbiQ75LS8.
PeptideAtlasiQ75LS8.
PRIDEiQ75LS8.

Expressioni

Gene expression databases

CleanExiHS_FKBP9L.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000242209.

Structurei

3D structure databases

ProteinModelPortaliQ75LS8.
SMRiQ75LS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 49PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST49
Domaini60 – 95EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini105 – 140EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
HOVERGENiHBG099817.
InParanoidiQ75LS8.
PhylomeDBiQ75LS8.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF13202. EF-hand_5. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75LS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMGLREMCV GEKRTVIIPP HLGYGEAGVD GEVPGSAVLV FDIELLELVA
60 70 80 90 100
GLPEGYMFIW NGEVSPNLFE EIDKDGNGEV LLEEFSEYIH AQVASGKGKL
110 120 130 140
APGFDAELIV KNMFTNQDRN GDGKVTAEEF KLKDQEAKQD EL
Length:142
Mass (Da):15,591
Last modified:July 5, 2004 - v1
Checksum:iF66152BABF6F9AF6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036962125V → G.Corresponds to variant rs11524166dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312981 mRNA. Translation: BAG35818.1.
AC091812 Genomic DNA. Translation: AAQ93369.1.
BC011872 mRNA. No translation available.
UniGeneiHs.446691.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312981 mRNA. Translation: BAG35818.1.
AC091812 Genomic DNA. Translation: AAQ93369.1.
BC011872 mRNA. No translation available.
UniGeneiHs.446691.

3D structure databases

ProteinModelPortaliQ75LS8.
SMRiQ75LS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000242209.

Polymorphism and mutation databases

DMDMi74758923.

Proteomic databases

MaxQBiQ75LS8.
PaxDbiQ75LS8.
PeptideAtlasiQ75LS8.
PRIDEiQ75LS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiFKBP9P1.
HGNCiHGNC:23568. FKBP9P1.
neXtProtiNX_Q75LS8.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
HOVERGENiHBG099817.
InParanoidiQ75LS8.
PhylomeDBiQ75LS8.

Enzyme and pathway databases

BioCyciZFISH:G66-31022-MONOMER.

Gene expression databases

CleanExiHS_FKBP9L.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF13202. EF-hand_5. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKB9L_HUMAN
AccessioniPrimary (citable) accession number: Q75LS8
Secondary accession number(s): B2R7H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. The FKBP domain is truncated.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.