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Protein

Mitogen-activated protein kinase 14

Gene

MPK14

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42ATPPROSITE-ProRule annotation1
Active sitei139Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 27ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-4086398 Ca2+ pathway
R-OSA-5687128 MAPK6/MAPK4 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 14 (EC:2.7.11.24)
Short name:
MAP kinase 14
Gene namesi
Name:MPK14
Ordered Locus Names:Os05g0143500, LOC_Os05g05160
ORF Names:OJ1264_A04.20, OJ1607_F09.3
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397571 – 542Mitogen-activated protein kinase 14Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphothreonineBy similarity1
Modified residuei177PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ75KK8
PRIDEiQ75KK8

Expressioni

Gene expression databases

ExpressionAtlasiQ75KK8 differential

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os05g05160.1

Structurei

3D structure databases

ProteinModelPortaliQ75KK8
SMRiQ75KK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 304Protein kinasePROSITE-ProRule annotationAdd BLAST292

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi175 – 177TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
InParanoidiQ75KK8
OMAiMTPSEMD
OrthoDBiEOG093605CF

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q75KK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFFTEYGEG NRYKIEEVIG KGSYGVVCSA LDTHTGDKVA IKKINDIFEH
60 70 80 90 100
VSDATRILRE IKLLRLLRHP DIVEIKHILL PPSRREFKDI YVVFELMESD
110 120 130 140 150
LHQVIKANDD LTPEHYQFFL YQLLRGLKYI HTANVFHRDL KPKNILANAD
160 170 180 190 200
CKLKICDFGL ARVAFSDTPT AIFWTDYIAT RWYRAPELCG SFFSKYTPAI
210 220 230 240 250
DIWSIGCIFA ELLTGKPLFP GKNVVHQLDI ITDLLGTPSP ETISRIRNEK
260 270 280 290 300
ARRYLNSMRR KKPIPFTQKF PNADPLAMRL LERMLAFDPK DRPSAEEALA
310 320 330 340 350
DPYFKNIANV DREPSAQPIT KLEFEFERRR ITKEDIRELI YREILEYHPK
360 370 380 390 400
MLREFLEGTE STGFMYPSAV DHFKKQFAYL EEHYAKGSTA APPERQHNSL
410 420 430 440 450
PRPCVVYSDN RPQSTASVTE DLSRCLIRDN NLKSQDSASV GASRIPQGAA
460 470 480 490 500
ARPGKAVGSV LRYGNCSTSA AEQQYEQRRV VRNPAIAPNS SVPLGSSYPR
510 520 530 540
RNQTCKSETG DVERIDSSQT GPPKPYVANK LPATVDGRSG HW
Length:542
Mass (Da):61,762
Last modified:July 5, 2004 - v1
Checksum:i1E797CEF2BD8631A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104277 Genomic DNA Translation: AAS98446.1
AC104283 Genomic DNA Translation: AAU90196.1
AP014961 Genomic DNA Translation: BAS92219.1
AK063944 mRNA No translation available.
RefSeqiXP_015639438.1, XM_015783952.1
UniGeneiOs.55311

Genome annotation databases

EnsemblPlantsiOs05t0143500-02; Os05t0143500-02; Os05g0143500
GeneIDi9267958
GrameneiOs05t0143500-02; Os05t0143500-02; Os05g0143500
KEGGiosa:9267958

Similar proteinsi

Entry informationi

Entry nameiMPK14_ORYSJ
AccessioniPrimary (citable) accession number: Q75KK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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