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Q75KK8

- MPK14_ORYSJ

UniProt

Q75KK8 - MPK14_ORYSJ

Protein

Mitogen-activated protein kinase 14

Gene

MPK14

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421ATPPROSITE-ProRule annotation
    Active sitei139 – 1391Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 14 (EC:2.7.11.24)
    Short name:
    MAP kinase 14
    Gene namesi
    Name:MPK14
    Ordered Locus Names:Os05g0143500, LOC_Os05g05160
    ORF Names:OJ1264_A04.20, OJ1607_F09.3
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 5

    Organism-specific databases

    GrameneiQ75KK8.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 542542Mitogen-activated protein kinase 14PRO_0000239757Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei175 – 1751PhosphothreonineBy similarity
    Modified residuei177 – 1771PhosphotyrosineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ75KK8.

    Interactioni

    Protein-protein interaction databases

    STRINGi39947.LOC_Os05g05160.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ75KK8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 304292Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi175 – 1773TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    OMAiESARYEL.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q75KK8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFFTEYGEG NRYKIEEVIG KGSYGVVCSA LDTHTGDKVA IKKINDIFEH    50
    VSDATRILRE IKLLRLLRHP DIVEIKHILL PPSRREFKDI YVVFELMESD 100
    LHQVIKANDD LTPEHYQFFL YQLLRGLKYI HTANVFHRDL KPKNILANAD 150
    CKLKICDFGL ARVAFSDTPT AIFWTDYIAT RWYRAPELCG SFFSKYTPAI 200
    DIWSIGCIFA ELLTGKPLFP GKNVVHQLDI ITDLLGTPSP ETISRIRNEK 250
    ARRYLNSMRR KKPIPFTQKF PNADPLAMRL LERMLAFDPK DRPSAEEALA 300
    DPYFKNIANV DREPSAQPIT KLEFEFERRR ITKEDIRELI YREILEYHPK 350
    MLREFLEGTE STGFMYPSAV DHFKKQFAYL EEHYAKGSTA APPERQHNSL 400
    PRPCVVYSDN RPQSTASVTE DLSRCLIRDN NLKSQDSASV GASRIPQGAA 450
    ARPGKAVGSV LRYGNCSTSA AEQQYEQRRV VRNPAIAPNS SVPLGSSYPR 500
    RNQTCKSETG DVERIDSSQT GPPKPYVANK LPATVDGRSG HW 542
    Length:542
    Mass (Da):61,762
    Last modified:July 5, 2004 - v1
    Checksum:i1E797CEF2BD8631A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC104277 Genomic DNA. Translation: AAS98446.1.
    AC104283 Genomic DNA. Translation: AAU90196.1.
    AK063944 mRNA. No translation available.

    Genome annotation databases

    EnsemblPlantsiOS05T0143500-02; OS05T0143500-02; OS05G0143500.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC104277 Genomic DNA. Translation: AAS98446.1 .
    AC104283 Genomic DNA. Translation: AAU90196.1 .
    AK063944 mRNA. No translation available.

    3D structure databases

    ProteinModelPortali Q75KK8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 39947.LOC_Os05g05160.1.

    Proteomic databases

    PRIDEi Q75KK8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS05T0143500-02 ; OS05T0143500-02 ; OS05G0143500 .

    Organism-specific databases

    Gramenei Q75KK8.

    Phylogenomic databases

    eggNOGi COG0515.
    OMAi ESARYEL.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.
    3. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
      Reyna N.S., Yang Y.
      Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiMPK14_ORYSJ
    AccessioniPrimary (citable) accession number: Q75KK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3