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Protein

Circularly permutated Ras protein 1

Gene

cpras1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 66GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4
Nucleotide bindingi181 – 188GTPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Circularly permutated Ras protein 1
Short name:
DdiCPRas1
Gene namesi
Name:cpras1
ORF Names:DDB_G0277381
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277381 cpras1

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003713471 – 842Circularly permutated Ras protein 1Add BLAST842

Proteomic databases

PaxDbiQ75J93
PRIDEiQ75J93

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0229980

Structurei

3D structure databases

ProteinModelPortaliQ75J93
SMRiQ75J93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini377 – 627VWFAPROSITE-ProRule annotationAdd BLAST251

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi29 – 34Poly-Thr6
Compositional biasi43 – 49Poly-Ser7
Compositional biasi181 – 186Poly-Gly6
Compositional biasi231 – 242Poly-SerAdd BLAST12

Domaini

In contrast to other GTP-binding proteins, it is characterized by a circular permutation of the GTPase motifs described by a G4-G3-G1 pattern.

Sequence similaritiesi

Belongs to the small GTPase superfamily. CpRas family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
InParanoidiQ75J93
OMAiEFCGHEN
PhylomeDBiQ75J93

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
IPR036174 Znf_Sec23_Sec24_sf
PfamiView protein in Pfam
PF00071 Ras, 2 hits
SMARTiView protein in SMART
SM00327 VWA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF53300 SSF53300, 1 hit
SSF82919 SSF82919, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Q75J93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFPTKYVYI TSNLDKPKEW FTQSEMSLTT TTDTIQKSFV NNSGSSSSSK
60 70 80 90 100
GFGEAVLLDI LDTAGQEEYS AMRDQYVRTG DCFMIVFSID SRSSFEEVSQ
110 120 130 140 150
LKQHIERVKD RDDVPIIIVG NKVDLESRRQ VSRIEADQLA RSLRVPYIET
160 170 180 190 200
SAKTRSNIEE AFFTLVRHTP RNTVYKVVVM GGGGVGKSAI IIQFIQNHFV
210 220 230 240 250
EEYDPTIEDS YRKQVTISGL PPIGGSLNKK SSSSSSSSSS SSGKTGLFNK
260 270 280 290 300
IFSGKDKQPS PQQAASPSTI DRTGQISTNR LEANVLSYSM SNLSKEVPLI
310 320 330 340 350
TGDCVYCQGC NVILSRFSNL VKTGDDSFTW KCEFCKYSNS NILLEQGEIP
360 370 380 390 400
NKDSVEYVLS SPSTSSTTDG SKREESIIIY CIDVSGSMGI TTEVPSLQSE
410 420 430 440 450
WVNAKKGVKG ASSGPSYISR LECVQSSIPT MIDRLSIQYP NKRVVLVTFS
460 470 480 490 500
DEVMIYTQSN SVDGPIVIAG DKLEDFDQLI EIGRSMTYDK LPTASGSSDF
510 520 530 540 550
LKAKIKSLEP VQSTALGPAL LVSAAIASQK MLSEVVICTD GVPNVGLGAI
560 570 580 590 600
EDLPLGPAQE FYEKVTKLAQ NNKTTINIIG ISGSHIDLGV IGKVSEQTNG
610 620 630 640 650
NITIIHPLEL AREIRKLTQN PMIATDVEMS ICLHPTLEIN KYDSKQGLSR
660 670 680 690 700
VVKQFPNVNS LTDLTLLYSS RNRPTEFVQI YPFQIQIKYT KLDGVRCLRV
710 720 730 740 750
VSAQLQATPD FNTSTSNANI SILAMAFTQQ AAKIAQQQEY MESRLHLKAA
760 770 780 790 800
TKLIRSLCNT DEQWEEFYNF EVLREEMEAP LITCIKNKQQ RVEKAATDDE
810 820 830 840
IQVFYKMKNV HKSFVEGGRK KDISRRKGEA EINKQYYNIK FT
Length:842
Mass (Da):93,475
Last modified:July 5, 2004 - v1
Checksum:i7A5C1A67E4887F22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000019 Genomic DNA Translation: EAL68747.1
RefSeqiXP_642673.1, XM_637581.1

Genome annotation databases

EnsemblProtistsiEAL68747; EAL68747; DDB_G0277381
GeneIDi8621003
KEGGiddi:DDB_G0277381

Similar proteinsi

Entry informationi

Entry nameiCPAS1_DICDI
AccessioniPrimary (citable) accession number: Q75J93
Secondary accession number(s): Q54ZR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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