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Protein

Cytochrome c oxidase subunit 3

Gene

COX3

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COX3
Ordered Locus Names:AMI003W
ORF Names:AgCOX3
Encoded oniMitochondrion
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei138 – 160HelicalSequence analysisAdd BLAST23
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001837421 – 269Cytochrome c oxidase subunit 3Add BLAST269

Interactioni

Subunit structurei

Composed of at least 11 subunits.

Protein-protein interaction databases

STRINGi33169.AAS50170

Structurei

3D structure databases

ProteinModelPortaliQ75G34
SMRiQ75G34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264954
InParanoidiQ75G34
KOiK02262
OMAiYYFVPGP
OrthoDBiEOG092C4IN0

Family and domain databases

CDDicd01665 Cyt_c_Oxidase_III, 1 hit
Gene3Di1.20.120.80, 1 hit
InterProiView protein in InterPro
IPR024791 Cyt_c/ubiquinol_Oxase_su3
IPR033945 Cyt_c_oxase_su3_dom
IPR000298 Cyt_c_oxidase-like_su3
IPR035973 Cyt_c_oxidase_su3-like_sf
IPR013833 Cyt_c_oxidase_su3_a-hlx
PANTHERiPTHR11403 PTHR11403, 1 hit
PfamiView protein in Pfam
PF00510 COX3, 1 hit
SUPFAMiSSF81452 SSF81452, 1 hit
PROSITEiView protein in PROSITE
PS50253 COX3, 1 hit

Sequencei

Sequence statusi: Complete.

Q75G34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYLNRSKFQ QFPFHLVTPS PWPIVTSFSL LGLTLTLAFT MHGIIGNIYP
60 70 80 90 100
LLLSLLVVLL TMTLWFRDIV AETTYLGDHT LAVRKGINLG FTLFVVSEVL
110 120 130 140 150
IFASLFWAYF HSAMSPDITL GNVWPPVGIE AVQPTELPLL NTIILLASGT
160 170 180 190 200
TITYSHHGLI EGNRKHALSG LTITFWLIVT FVLCQYIEYS NTSFTITDGI
210 220 230 240 250
YGSVFFAGTG LHFLHMVMLT IMLGINYWRM RNYHLTSTHH VGYETTTIYL
260
HVLDIIWLAL YICFYWWGV
Length:269
Mass (Da):30,622
Last modified:July 5, 2004 - v1
Checksum:i593DCBA0BBBE7CA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016821 Genomic DNA Translation: AAS50170.1
RefSeqiNP_987080.1, NC_005789.1

Genome annotation databases

EnsemblFungiiAAS50170; AAS50170; AGOS_AMI003W
GeneIDi2760768
KEGGiago:AGOS_AMI003W

Similar proteinsi

Entry informationi

Entry nameiCOX3_ASHGO
AccessioniPrimary (citable) accession number: Q75G34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health