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Protein

Mitochondrial thiamine pyrophosphate carrier 1

Gene

TPC1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine pyrophosphate carrier 1
Gene namesi
Name:TPC1
Ordered Locus Names:AAR036W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome I

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei86 – 106Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei122 – 142Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei176 – 196Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei207 – 227Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei281 – 300Helical; Name=6Sequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003204541 – 317Mitochondrial thiamine pyrophosphate carrier 1Add BLAST317

Interactioni

Protein-protein interaction databases

STRINGi33169.AAS50401.

Structurei

3D structure databases

ProteinModelPortaliQ75EP3.
SMRiQ75EP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 109Solcar 1Add BLAST88
Repeati116 – 201Solcar 2Add BLAST86
Repeati206 – 306Solcar 3Add BLAST101

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000165726.
InParanoidiQ75EP3.
KOiK15108.
OMAiWKGNVPA.
OrthoDBiEOG092C3KDM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q75EP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASSGSPQL ATEDHLRKGE AVSGLHAVVA GSVSGLVARS VTAPMDTVKI
60 70 80 90 100
RRQLQLASEH KYHGILHTFR TVAREEGVRA LWKGNVPASA MYVLYGSLQF
110 120 130 140 150
GTYAWLNTAA ASAGLPPQAH SLAVGALAGL VSSLLTYPLD LLRTRLVANR
160 170 180 190 200
SAHFFSLRRQ ARVIWDTEGP AGFFRGGAWA IAATTLTTGL IFGIYETCTI
210 220 230 240 250
AADTYGLPWL AAAASPTAGL VSKAAVFPLD TVRRRLQIVD AKHIPFFTRD
260 270 280 290 300
PGAYSALRGT RFLGLAVHMV RAEGIASLYK GLTMALCKST PTTVITLWVY
310
QRCLRLLEPT RAPQLPA
Length:317
Mass (Da):33,996
Last modified:July 5, 2004 - v1
Checksum:i33F90C9303B8E2A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016814 Genomic DNA. Translation: AAS50401.1.
RefSeqiNP_982577.1. NM_207930.1.

Genome annotation databases

EnsemblFungiiAAS50401; AAS50401; AGOS_AAR036W.
GeneIDi4618442.
KEGGiago:AGOS_AAR036W.

Similar proteinsi

Entry informationi

Entry nameiTPC1_ASHGO
AccessioniPrimary (citable) accession number: Q75EP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: July 5, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families