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Q75E60

- SSU72_ASHGO

UniProt

Q75E60 - SSU72_ASHGO

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Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene
SSU72, ABL190W
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1) By similarity.
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
Short name:
CTD phosphatase SSU72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:SSU72
Ordered Locus Names:ABL190W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome II

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281RNA polymerase II subunit A C-terminal domain phosphatase SSU72PRO_0000255602Add
BLAST

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex By similarity.

Protein-protein interaction databases

STRINGi33169.AGOS_ABL190W.

Structurei

3D structure databases

ProteinModelPortaliQ75E60.

Family & Domainsi

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.

Phylogenomic databases

eggNOGiCOG5211.
HOGENOMiHOG000183445.
KOiK15544.
OMAiWQERWPN.
OrthoDBiEOG7GTTG0.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75E60-1 [UniParc]FASTAAdd to Basket

« Hide

MAPKRGSSPA IAGHCSLILS RGLPSVRVTD SNRQKKLIRH LHTFLLYLPA    50
DTSCGYRPEC GAASFRTRQS SLMVSSEMPN TSTLRLCTVC ASNNNRSMES 100
HRVLKEAGYD VSSYGTGSAV RLPGLSIDKP NVYPFGTPYN DIYNDLLAQS 150
AERYKSNGLL EMLDRNRRIK KAPEKWHDSQ KVFDFVFTCE ERCFDSVCED 200
LMNRGGQLNK IVHVINLDIR DDNENAKIGG RAMLELVKAL NSKMQECDQQ 250
GVPFEDTIMD VVADWQQAHP QLPLLYSPAY Y 281
Length:281
Mass (Da):31,588
Last modified:July 5, 2004 - v1
Checksum:i3D3D5DBD42239466
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016815 Genomic DNA. Translation: AAS50581.1.
RefSeqiNP_982757.1. NM_208110.1.

Genome annotation databases

EnsemblFungiiAAS50581; AAS50581; AGOS_ABL190W.
GeneIDi4618836.
KEGGiago:AGOS_ABL190W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016815 Genomic DNA. Translation: AAS50581.1 .
RefSeqi NP_982757.1. NM_208110.1.

3D structure databases

ProteinModelPortali Q75E60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_ABL190W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAS50581 ; AAS50581 ; AGOS_ABL190W .
GeneIDi 4618836.
KEGGi ago:AGOS_ABL190W.

Phylogenomic databases

eggNOGi COG5211.
HOGENOMi HOG000183445.
KOi K15544.
OMAi WQERWPN.
OrthoDBi EOG7GTTG0.

Family and domain databases

InterProi IPR006811. RNA_pol_II_suA.
[Graphical view ]
PANTHERi PTHR20383. PTHR20383. 1 hit.
Pfami PF04722. Ssu72. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiSSU72_ASHGO
AccessioniPrimary (citable) accession number: Q75E60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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