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Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

SSU72

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).By similarity
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
Short name:
CTD phosphatase SSU72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:SSU72
Ordered Locus Names:ABL190W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591 Componenti: Chromosome II

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281RNA polymerase II subunit A C-terminal domain phosphatase SSU72PRO_0000255602Add
BLAST

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ75E60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.Curated

Phylogenomic databases

eggNOGiCOG5211.
HOGENOMiHOG000183445.
InParanoidiQ75E60.
KOiK15544.
OMAiWQERWPN.
OrthoDBiEOG7GTTG0.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75E60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKRGSSPA IAGHCSLILS RGLPSVRVTD SNRQKKLIRH LHTFLLYLPA
60 70 80 90 100
DTSCGYRPEC GAASFRTRQS SLMVSSEMPN TSTLRLCTVC ASNNNRSMES
110 120 130 140 150
HRVLKEAGYD VSSYGTGSAV RLPGLSIDKP NVYPFGTPYN DIYNDLLAQS
160 170 180 190 200
AERYKSNGLL EMLDRNRRIK KAPEKWHDSQ KVFDFVFTCE ERCFDSVCED
210 220 230 240 250
LMNRGGQLNK IVHVINLDIR DDNENAKIGG RAMLELVKAL NSKMQECDQQ
260 270 280
GVPFEDTIMD VVADWQQAHP QLPLLYSPAY Y
Length:281
Mass (Da):31,588
Last modified:July 5, 2004 - v1
Checksum:i3D3D5DBD42239466
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016815 Genomic DNA. Translation: AAS50581.1.
RefSeqiNP_982757.1. NM_208110.1.

Genome annotation databases

EnsemblFungiiAAS50581; AAS50581; AGOS_ABL190W.
GeneIDi4618836.
KEGGiago:AGOS_ABL190W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016815 Genomic DNA. Translation: AAS50581.1.
RefSeqiNP_982757.1. NM_208110.1.

3D structure databases

ProteinModelPortaliQ75E60.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS50581; AAS50581; AGOS_ABL190W.
GeneIDi4618836.
KEGGiago:AGOS_ABL190W.

Phylogenomic databases

eggNOGiCOG5211.
HOGENOMiHOG000183445.
InParanoidiQ75E60.
KOiK15544.
OMAiWQERWPN.
OrthoDBiEOG7GTTG0.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiSSU72_ASHGO
AccessioniPrimary (citable) accession number: Q75E60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.