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Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

SSU72

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).By similarity
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
Short name:
CTD phosphatase SSU72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:SSU72
Ordered Locus Names:ABL190W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Chromosome II

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002556021 – 281RNA polymerase II subunit A C-terminal domain phosphatase SSU72Add BLAST281

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex.By similarity

Protein-protein interaction databases

STRINGi33169.AAS50581

Structurei

3D structure databases

ProteinModelPortaliQ75E60
SMRiQ75E60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.Curated

Phylogenomic databases

HOGENOMiHOG000183445
InParanoidiQ75E60
KOiK15544
OMAiWQERWPN
OrthoDBiEOG092C4UKX

Family and domain databases

InterProiView protein in InterPro
IPR006811 RNA_pol_II_suA
PANTHERiPTHR20383 PTHR20383, 1 hit
PfamiView protein in Pfam
PF04722 Ssu72, 1 hit

Sequencei

Sequence statusi: Complete.

Q75E60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKRGSSPA IAGHCSLILS RGLPSVRVTD SNRQKKLIRH LHTFLLYLPA
60 70 80 90 100
DTSCGYRPEC GAASFRTRQS SLMVSSEMPN TSTLRLCTVC ASNNNRSMES
110 120 130 140 150
HRVLKEAGYD VSSYGTGSAV RLPGLSIDKP NVYPFGTPYN DIYNDLLAQS
160 170 180 190 200
AERYKSNGLL EMLDRNRRIK KAPEKWHDSQ KVFDFVFTCE ERCFDSVCED
210 220 230 240 250
LMNRGGQLNK IVHVINLDIR DDNENAKIGG RAMLELVKAL NSKMQECDQQ
260 270 280
GVPFEDTIMD VVADWQQAHP QLPLLYSPAY Y
Length:281
Mass (Da):31,588
Last modified:July 5, 2004 - v1
Checksum:i3D3D5DBD42239466
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016815 Genomic DNA Translation: AAS50581.1
RefSeqiNP_982757.1, NM_208110.1

Genome annotation databases

EnsemblFungiiAAS50581; AAS50581; AGOS_ABL190W
GeneIDi4618836
KEGGiago:AGOS_ABL190W

Similar proteinsi

Entry informationi

Entry nameiSSU72_ASHGO
AccessioniPrimary (citable) accession number: Q75E60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health