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Q75E60

- SSU72_ASHGO

UniProt

Q75E60 - SSU72_ASHGO

Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

SSU72

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).By similarity
    Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    mRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
    Short name:
    CTD phosphatase SSU72
    Alternative name(s):
    Suppressor of SUA7 protein 2 homolog
    Gene namesi
    Name:SSU72
    Ordered Locus Names:ABL190W
    OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
    Taxonomic identifieri284811 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
    ProteomesiUP000000591: Chromosome II

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281RNA polymerase II subunit A C-terminal domain phosphatase SSU72PRO_0000255602Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the cleavage and polyadenylation factor (CPF) complex.By similarity

    Protein-protein interaction databases

    STRINGi33169.AGOS_ABL190W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ75E60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SSU72 phosphatase family.Curated

    Phylogenomic databases

    eggNOGiCOG5211.
    HOGENOMiHOG000183445.
    KOiK15544.
    OMAiWQERWPN.
    OrthoDBiEOG7GTTG0.

    Family and domain databases

    InterProiIPR006811. RNA_pol_II_suA.
    [Graphical view]
    PANTHERiPTHR20383. PTHR20383. 1 hit.
    PfamiPF04722. Ssu72. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q75E60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPKRGSSPA IAGHCSLILS RGLPSVRVTD SNRQKKLIRH LHTFLLYLPA    50
    DTSCGYRPEC GAASFRTRQS SLMVSSEMPN TSTLRLCTVC ASNNNRSMES 100
    HRVLKEAGYD VSSYGTGSAV RLPGLSIDKP NVYPFGTPYN DIYNDLLAQS 150
    AERYKSNGLL EMLDRNRRIK KAPEKWHDSQ KVFDFVFTCE ERCFDSVCED 200
    LMNRGGQLNK IVHVINLDIR DDNENAKIGG RAMLELVKAL NSKMQECDQQ 250
    GVPFEDTIMD VVADWQQAHP QLPLLYSPAY Y 281
    Length:281
    Mass (Da):31,588
    Last modified:July 5, 2004 - v1
    Checksum:i3D3D5DBD42239466
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016815 Genomic DNA. Translation: AAS50581.1.
    RefSeqiNP_982757.1. NM_208110.1.

    Genome annotation databases

    EnsemblFungiiAAS50581; AAS50581; AGOS_ABL190W.
    GeneIDi4618836.
    KEGGiago:AGOS_ABL190W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016815 Genomic DNA. Translation: AAS50581.1 .
    RefSeqi NP_982757.1. NM_208110.1.

    3D structure databases

    ProteinModelPortali Q75E60.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33169.AGOS_ABL190W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAS50581 ; AAS50581 ; AGOS_ABL190W .
    GeneIDi 4618836.
    KEGGi ago:AGOS_ABL190W.

    Phylogenomic databases

    eggNOGi COG5211.
    HOGENOMi HOG000183445.
    KOi K15544.
    OMAi WQERWPN.
    OrthoDBi EOG7GTTG0.

    Family and domain databases

    InterProi IPR006811. RNA_pol_II_suA.
    [Graphical view ]
    PANTHERi PTHR20383. PTHR20383. 1 hit.
    Pfami PF04722. Ssu72. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
      Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
      Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
    2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
      Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
      G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

    Entry informationi

    Entry nameiSSU72_ASHGO
    AccessioniPrimary (citable) accession number: Q75E60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3