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Q75DY2

- RIFK_ASHGO

UniProt

Q75DY2 - RIFK_ASHGO

Protein

Riboflavin kinase

Gene

FMN1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.By similarity

    Catalytic activityi

    ATP + riboflavin = ADP + FMN.

    Cofactori

    Zinc or magnesium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi42 – 421Magnesium or zincBy similarity
    Active sitei123 – 1231NucleophileBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. riboflavin kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. FMN biosynthetic process Source: UniProtKB-UniPathway
    2. riboflavin biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Flavoprotein, FMN, Magnesium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00276; UER00406.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Riboflavin kinase (EC:2.7.1.26)
    Alternative name(s):
    Flavin mononucleotide kinase 1
    Gene namesi
    Name:FMN1
    Ordered Locus Names:ABL109W
    OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
    Taxonomic identifieri284811 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
    ProteomesiUP000000591: Chromosome II

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: EnsemblFungi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 186186Riboflavin kinasePRO_0000301832Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi33169.AGOS_ABL109W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ75DY2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the flavokinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0196.
    HOGENOMiHOG000260803.
    KOiK00861.
    OrthoDBiEOG7K3V05.

    Family and domain databases

    Gene3Di2.40.30.30. 1 hit.
    InterProiIPR023468. Riboflavin_kinase.
    IPR015865. Riboflavin_kinase_bac/euk.
    IPR023465. Riboflavin_kinase_domain.
    [Graphical view]
    PANTHERiPTHR22749. PTHR22749. 1 hit.
    PfamiPF01687. Flavokinase. 1 hit.
    [Graphical view]
    SMARTiSM00904. Flavokinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF82114. SSF82114. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q75DY2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARRPVDIPI PASPVQPFPI LTEYVDIVAG FGRGSAELGI PTANVPIEQL    50
    PSEVNEMATG VYFGWARLRP NMDQEAQVHH RNDGSEVIYN FGSKLSETER 100
    GVFPIVLSVG WNPFYNNSKK TVELHILNDF EEDFYGAKIK FSFLGYIRPE 150
    LNYTTKEALI EDIHTDIKIA SEVLHTEPYS SLKNQL 186
    Length:186
    Mass (Da):20,984
    Last modified:September 11, 2007 - v2
    Checksum:iDA16FB2E83EF3A9E
    GO

    Sequence cautioni

    The sequence AAS50662.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016815 Genomic DNA. Translation: AAS50662.1. Different initiation.
    RefSeqiNP_982838.1. NM_208191.1.

    Genome annotation databases

    GeneIDi4618918.
    KEGGiago:AGOS_ABL109W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016815 Genomic DNA. Translation: AAS50662.1 . Different initiation.
    RefSeqi NP_982838.1. NM_208191.1.

    3D structure databases

    ProteinModelPortali Q75DY2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33169.AGOS_ABL109W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4618918.
    KEGGi ago:AGOS_ABL109W.

    Phylogenomic databases

    eggNOGi COG0196.
    HOGENOMi HOG000260803.
    KOi K00861.
    OrthoDBi EOG7K3V05.

    Enzyme and pathway databases

    UniPathwayi UPA00276 ; UER00406 .

    Family and domain databases

    Gene3Di 2.40.30.30. 1 hit.
    InterProi IPR023468. Riboflavin_kinase.
    IPR015865. Riboflavin_kinase_bac/euk.
    IPR023465. Riboflavin_kinase_domain.
    [Graphical view ]
    PANTHERi PTHR22749. PTHR22749. 1 hit.
    Pfami PF01687. Flavokinase. 1 hit.
    [Graphical view ]
    SMARTi SM00904. Flavokinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82114. SSF82114. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
      Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
      Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
    2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
      Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
      G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

    Entry informationi

    Entry nameiRIFK_ASHGO
    AccessioniPrimary (citable) accession number: Q75DY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3