Q75DY2 (RIFK_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Riboflavin kinase
EC=2.7.1.26

Alternative name(s):
Flavin mononucleotide kinase 1

Gene names

Name:	FMN1
Ordered Locus Names:	ABL109W

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium › Ashbya gossypii

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme By similarity.
Catalytic activity	ATP + riboflavin = ADP + FMN.
Cofactor	Zinc or magnesium By similarity.
Pathway	Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.
Sequence similarities	Belongs to the flavokinase family.
Sequence caution	The sequence AAS50662.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	ATP-binding FMN Magnesium Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	FMN biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway riboflavin biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: EnsemblFungi
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW riboflavin kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	Riboflavin kinase		PRO_0000301832
Sites
	Active site	123	1	Nucleophile By similarity
	Metal binding	42	1	Magnesium or zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q75DY2 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: DA16FB2E83EF3A9E	FASTA	186	20,984
	10 20 30 40 50 60 MARRPVDIPI PASPVQPFPI LTEYVDIVAG FGRGSAELGI PTANVPIEQL PSEVNEMATG 70 80 90 100 110 120 VYFGWARLRP NMDQEAQVHH RNDGSEVIYN FGSKLSETER GVFPIVLSVG WNPFYNNSKK 130 140 150 160 170 180 TVELHILNDF EEDFYGAKIK FSFLGYIRPE LNYTTKEALI EDIHTDIKIA SEVLHTEPYS SLKNQL

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016815 Genomic DNA. Translation: AAS50662.1. Different initiation.
RefSeq	NP_982838.1. NM_208191.1.
3D structure databases
HSSP	HSSP built from PDB template 1N08 based on UniProtKB O74866.
ProteinModelPortal	Q75DY2.
ModBase	Search...
Protein-protein interaction databases
STRING	33169.AGOS_ABL109W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4618918.
KEGG	ago:AGOS_ABL109W.
Phylogenomic databases
eggNOG	COG0196.
HOGENOM	HOG000260803.
KO	K00861.
OrthoDB	EOG4BCHXC.
Enzyme and pathway databases
UniPathway	UPA00276; UER00406.
Family and domain databases
Gene3D	2.40.30.30. 1 hit.
InterPro	IPR023468. Riboflavin_kinase. IPR015865. Riboflavin_kinase_bac/euk. IPR023465. Riboflavin_kinase_domain. [Graphical view]
PANTHER	PTHR22749. PTHR22749. 1 hit.
Pfam	PF01687. Flavokinase. 1 hit. [Graphical view]
SMART	SM00904. Flavokinase. 1 hit. [Graphical view]
SUPFAM	SSF82114. Riboflavin_kinase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RIFK_ASHGO

Accession

Primary (citable) accession number: Q75DY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	May 1, 2013
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program