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Q75D46

- BUR1_ASHGO

UniProt

Q75D46 - BUR1_ASHGO

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Protein
Serine/threonine-protein kinase BUR1
Gene
BUR1, ABR177C
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851ATP By similarity
Active sitei201 – 2011Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 709ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:BUR1
Ordered Locus Names:ABR177C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome II

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 753753Serine/threonine-protein kinase BUR1
PRO_0000085677Add
BLAST

Proteomic databases

PRIDEiQ75D46.

Interactioni

Protein-protein interaction databases

STRINGi33169.AGOS_ABR177C.

Structurei

3D structure databases

ProteinModelPortaliQ75D46.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 372317Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi420 – 48364Gln-rich
Add
BLAST
Compositional biasi528 – 57952Tyr-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
KOiK15562.
OMAiCEESHET.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75D46-1 [UniParc]FASTAAdd to Basket

« Hide

MSQEGSAKRA DFKYKIGKIK HTPPVLKDVR SGLEFIELEK RDDEKVYGVT    50
KFLGNYKEEK KLGQGTFGEV YRGVHLATQR QVAMKKILVK TENDLFPITA 100
QREITILKRL NHRNVVQLIE MVYDYPPAQN GAAYGQDSSQ ASASADTMKS 150
FYMILPYMVA DLSGILHNPR VTLEMADIKN MMLQILEGIN YIHCKKFMHR 200
DIKTANILLD HKGILKIADF GLARNYYGAP PNLKYPGGAG TDAKYTSVVV 250
TRWYRAPELV LGDKNYTTAV DIWGIGCVFA EFFEKRPILQ GKTDIDQGHV 300
IFKLMGTPSD SDWQLARYLP GAELTRTSYE PTYKERFGKY LTEKGLDLLS 350
TLLSLDPYKR LTAMAAMQHP FFSEDPLPKL QLTLPCEESH ETDIARYGQE 400
MQKTVSNLPP AAPSGHAVEQ SQTQQQSSRH HQSQPYQSLP PQKSSQPHPQ 450
QIPEAAPVQQ PSQQPPQEPS AHQQQYSSRG PQQHRTTPAP TSLPPKPKPA 500
PPGARYNREA PPQNKPVKPL TRHLGAQYQH NNYGNYYNHW QGGERYYETY 550
NDGYPHADRY SDDTHYNGYG YRSRGYQRYD MRREGESRYN QRPYAPQQGA 600
AYRPNRRDTY KLVDRTGQPY PPERVPNPEL HPSPAPRPKR TLTNTTQLSS 650
HSSAATGSTA ASGSAVSNSS EPVRRSSTAS LDNSESGNIL QQKPPPPVAN 700
PLEARIYGRD EVQSNHPGGR LYPRSTPDSK NSEGAAPSEA STDPTKRNIV 750
DYY 753
Length:753
Mass (Da):84,823
Last modified:July 5, 2004 - v1
Checksum:i8F60C0B2E803FFF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016815 Genomic DNA. Translation: AAS50949.1.
RefSeqiNP_983125.1. NM_208478.1.

Genome annotation databases

EnsemblFungiiAAS50949; AAS50949; AGOS_ABR177C.
GeneIDi4619235.
KEGGiago:AGOS_ABR177C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016815 Genomic DNA. Translation: AAS50949.1 .
RefSeqi NP_983125.1. NM_208478.1.

3D structure databases

ProteinModelPortali Q75D46.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_ABR177C.

Proteomic databases

PRIDEi Q75D46.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAS50949 ; AAS50949 ; AGOS_ABR177C .
GeneIDi 4619235.
KEGGi ago:AGOS_ABR177C.

Phylogenomic databases

eggNOGi COG0515.
KOi K15562.
OMAi CEESHET.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiBUR1_ASHGO
AccessioniPrimary (citable) accession number: Q75D46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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