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Q75D46 (BUR1_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase BUR1

EC=2.7.11.22
EC=2.7.11.23
Gene names
Name:BUR1
Ordered Locus Names:ABR177C
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium

Protein attributes

Sequence length753 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 753753Serine/threonine-protein kinase BUR1
PRO_0000085677

Regions

Domain56 – 372317Protein kinase
Nucleotide binding62 – 709ATP By similarity
Compositional bias420 – 48364Gln-rich
Compositional bias528 – 57952Tyr-rich

Sites

Active site2011Proton acceptor By similarity
Binding site851ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q75D46 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 8F60C0B2E803FFF0

FASTA75384,823
        10         20         30         40         50         60 
MSQEGSAKRA DFKYKIGKIK HTPPVLKDVR SGLEFIELEK RDDEKVYGVT KFLGNYKEEK 

        70         80         90        100        110        120 
KLGQGTFGEV YRGVHLATQR QVAMKKILVK TENDLFPITA QREITILKRL NHRNVVQLIE 

       130        140        150        160        170        180 
MVYDYPPAQN GAAYGQDSSQ ASASADTMKS FYMILPYMVA DLSGILHNPR VTLEMADIKN 

       190        200        210        220        230        240 
MMLQILEGIN YIHCKKFMHR DIKTANILLD HKGILKIADF GLARNYYGAP PNLKYPGGAG 

       250        260        270        280        290        300 
TDAKYTSVVV TRWYRAPELV LGDKNYTTAV DIWGIGCVFA EFFEKRPILQ GKTDIDQGHV 

       310        320        330        340        350        360 
IFKLMGTPSD SDWQLARYLP GAELTRTSYE PTYKERFGKY LTEKGLDLLS TLLSLDPYKR 

       370        380        390        400        410        420 
LTAMAAMQHP FFSEDPLPKL QLTLPCEESH ETDIARYGQE MQKTVSNLPP AAPSGHAVEQ 

       430        440        450        460        470        480 
SQTQQQSSRH HQSQPYQSLP PQKSSQPHPQ QIPEAAPVQQ PSQQPPQEPS AHQQQYSSRG 

       490        500        510        520        530        540 
PQQHRTTPAP TSLPPKPKPA PPGARYNREA PPQNKPVKPL TRHLGAQYQH NNYGNYYNHW 

       550        560        570        580        590        600 
QGGERYYETY NDGYPHADRY SDDTHYNGYG YRSRGYQRYD MRREGESRYN QRPYAPQQGA 

       610        620        630        640        650        660 
AYRPNRRDTY KLVDRTGQPY PPERVPNPEL HPSPAPRPKR TLTNTTQLSS HSSAATGSTA 

       670        680        690        700        710        720 
ASGSAVSNSS EPVRRSSTAS LDNSESGNIL QQKPPPPVAN PLEARIYGRD EVQSNHPGGR 

       730        740        750 
LYPRSTPDSK NSEGAAPSEA STDPTKRNIV DYY 

« Hide

References

« Hide 'large scale' references
[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]"Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016815 Genomic DNA. Translation: AAS50949.1.
RefSeqNP_983125.1. NM_208478.1.

3D structure databases

ProteinModelPortalQ75D46.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33169.AGOS_ABR177C.

Proteomic databases

PRIDEQ75D46.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiAAS50949; AAS50949; AGOS_ABR177C.
GeneID4619235.
KEGGago:AGOS_ABR177C.

Phylogenomic databases

eggNOGCOG0515.
KOK15562.
OMACEESHET.
OrthoDBEOG7K3TWD.
PhylomeDBQ75D46.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBUR1_ASHGO
AccessionPrimary (citable) accession number: Q75D46
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families