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Q75D46

- BUR1_ASHGO

UniProt

Q75D46 - BUR1_ASHGO

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Protein

Serine/threonine-protein kinase BUR1

Gene

BUR1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851ATPPROSITE-ProRule annotation
Active sitei201 – 2011Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 709ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:BUR1
Ordered Locus Names:ABR177C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome II

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 753753Serine/threonine-protein kinase BUR1PRO_0000085677Add
BLAST

Proteomic databases

PRIDEiQ75D46.

Interactioni

Protein-protein interaction databases

STRINGi33169.AGOS_ABR177C.

Structurei

3D structure databases

ProteinModelPortaliQ75D46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 372317Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi420 – 48364Gln-richAdd
BLAST
Compositional biasi528 – 57952Tyr-richAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ75D46.
KOiK15562.
OMAiCEESHET.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75D46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQEGSAKRA DFKYKIGKIK HTPPVLKDVR SGLEFIELEK RDDEKVYGVT
60 70 80 90 100
KFLGNYKEEK KLGQGTFGEV YRGVHLATQR QVAMKKILVK TENDLFPITA
110 120 130 140 150
QREITILKRL NHRNVVQLIE MVYDYPPAQN GAAYGQDSSQ ASASADTMKS
160 170 180 190 200
FYMILPYMVA DLSGILHNPR VTLEMADIKN MMLQILEGIN YIHCKKFMHR
210 220 230 240 250
DIKTANILLD HKGILKIADF GLARNYYGAP PNLKYPGGAG TDAKYTSVVV
260 270 280 290 300
TRWYRAPELV LGDKNYTTAV DIWGIGCVFA EFFEKRPILQ GKTDIDQGHV
310 320 330 340 350
IFKLMGTPSD SDWQLARYLP GAELTRTSYE PTYKERFGKY LTEKGLDLLS
360 370 380 390 400
TLLSLDPYKR LTAMAAMQHP FFSEDPLPKL QLTLPCEESH ETDIARYGQE
410 420 430 440 450
MQKTVSNLPP AAPSGHAVEQ SQTQQQSSRH HQSQPYQSLP PQKSSQPHPQ
460 470 480 490 500
QIPEAAPVQQ PSQQPPQEPS AHQQQYSSRG PQQHRTTPAP TSLPPKPKPA
510 520 530 540 550
PPGARYNREA PPQNKPVKPL TRHLGAQYQH NNYGNYYNHW QGGERYYETY
560 570 580 590 600
NDGYPHADRY SDDTHYNGYG YRSRGYQRYD MRREGESRYN QRPYAPQQGA
610 620 630 640 650
AYRPNRRDTY KLVDRTGQPY PPERVPNPEL HPSPAPRPKR TLTNTTQLSS
660 670 680 690 700
HSSAATGSTA ASGSAVSNSS EPVRRSSTAS LDNSESGNIL QQKPPPPVAN
710 720 730 740 750
PLEARIYGRD EVQSNHPGGR LYPRSTPDSK NSEGAAPSEA STDPTKRNIV

DYY
Length:753
Mass (Da):84,823
Last modified:July 5, 2004 - v1
Checksum:i8F60C0B2E803FFF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016815 Genomic DNA. Translation: AAS50949.1.
RefSeqiNP_983125.1. NM_208478.1.

Genome annotation databases

EnsemblFungiiAAS50949; AAS50949; AGOS_ABR177C.
GeneIDi4619235.
KEGGiago:AGOS_ABR177C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016815 Genomic DNA. Translation: AAS50949.1 .
RefSeqi NP_983125.1. NM_208478.1.

3D structure databases

ProteinModelPortali Q75D46.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_ABR177C.

Proteomic databases

PRIDEi Q75D46.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAS50949 ; AAS50949 ; AGOS_ABR177C .
GeneIDi 4619235.
KEGGi ago:AGOS_ABR177C.

Phylogenomic databases

eggNOGi COG0515.
InParanoidi Q75D46.
KOi K15562.
OMAi CEESHET.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiBUR1_ASHGO
AccessioniPrimary (citable) accession number: Q75D46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3