Q75CW5 (QCR2_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome b-c1 complex subunit 2, mitochondrial

Alternative name(s):
Complex III subunit 2
Core protein II
Ubiquinol-cytochrome-c reductase complex core protein 2

Gene names

Name:	QCR2
Ordered Locus Names:	ACL199C

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium › Ashbya gossypii

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex By similarity.
Subunit structure	Fungi bc1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins By similarity.
Subcellular location	Mitochondrion inner membrane By similarity.
Sequence similarities	Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.
Caution	Does not seem to have a protease activity as it lack the zinc-binding site.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic respiration Inferred from electronic annotation. Source: EnsemblFungi mitochondrial electron transport, ubiquinol to cytochrome c Inferred from electronic annotation. Source: EnsemblFungi
Cellular_component	mitochondrial crista Inferred from electronic annotation. Source: EnsemblFungi mitochondrial respiratory chain complex III Inferred from electronic annotation. Source: EnsemblFungi
Molecular_function	metal ion binding Inferred from electronic annotation. Source: InterPro ubiquinol-cytochrome-c reductase activity Inferred from electronic annotation. Source: EnsemblFungi
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 15	15	Mitochondrion By similarity
	Chain	16 – 366	351	Cytochrome b-c1 complex subunit 2, mitochondrial		PRO_0000026794

Sequences

	Sequence		Length	Mass (Da)
	Q75CW5 [UniParc]. Last modified January 9, 2013. Version 2. Checksum: B0A46B5B605A15D0	FASTA	366	39,229
	10 20 30 40 50 60 MLSQRLQCSK QFARHLSVAA KDGSGKVSTL SVQVQGGSRY ATKDGVAHLL SRFNFHNTGN 70 80 90 100 110 120 KSALRLVRES ELLGGRFQST VDREHITLSA TFLKEDLPYF VNALADVLYK TSFRPHELAE 130 140 150 160 170 180 SVLPAATRDA AVARACPVAA AEEALYSVTY RHGLGKPVLY DGVEKVTLED IKAYADKVYT 190 200 210 220 230 240 KENVTVLGQG INEADLKRFV NDSLLASLPS GTSLAGSGNA KTHSGEARLR HAGSSVAAIA 250 260 270 280 290 300 VPVAKADFAT YEVLARYLTS DLYALSPLVH KAKLDKYTDG GLFSLYVKSA EAAKAAADIK 310 320 330 340 350 360 KVVADLKAGK DISVARKYAA LQLAVENDSA ASPVSLKLEN AKDFKLGKFN YVAVGDVSNL PFADEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]	Dietrich F.S., Voegeli S., Philippsen P. Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 19; 108; 110; 269; 274; 281; 283; 297; 313-314; 323; 330 AND 346.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016816 Genomic DNA. Translation: AAS51029.2.
RefSeq	NP_983205.2. NM_208558.2.
3D structure databases
ProteinModelPortal	Q75CW5.
ModBase	Search...
Protein-protein interaction databases
STRING	33169.AGOS_ACL199C.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4619325.
KEGG	ago:AGOS_ACL199C.
Phylogenomic databases
eggNOG	COG0612.
HOGENOM	HOG000159494.
KO	K00415.
OMA	YITLKAT.
OrthoDB	EOG4Q2HPZ.
Family and domain databases
Gene3D	3.30.830.10. 2 hits.
InterPro	IPR011249. Metalloenz_LuxS/M16. IPR011237. Pept_M16_dom. IPR011765. Pept_M16_N. IPR007863. Peptidase_M16_C. [Graphical view]
Pfam	PF00675. Peptidase_M16. 1 hit. PF05193. Peptidase_M16_C. 1 hit. [Graphical view]
SUPFAM	SSF63411. Metalloenz_metal-bd. 2 hits.
ProtoNet	Search...

Entry information

Entry name

QCR2_ASHGO

Accession

Primary (citable) accession number: Q75CW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	January 9, 2013
Last modified:	May 1, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program