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Protein

Cytochrome b-c1 complex subunit 2, mitochondrial

Gene

QCR2

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 2, mitochondrial
Alternative name(s):
Complex III subunit 2
Core protein II
Ubiquinol-cytochrome-c reductase complex core protein 2
Gene namesi
Name:QCR2
Ordered Locus Names:ACL199C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591 Componenti: Chromosome III

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1515MitochondrionBy similarityAdd
BLAST
Chaini16 – 366351Cytochrome b-c1 complex subunit 2, mitochondrialPRO_0000026794Add
BLAST

Interactioni

Subunit structurei

Fungi bc1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins.By similarity

Protein-protein interaction databases

STRINGi33169.AGOS_ACL199C.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0612.
HOGENOMiHOG000159494.
InParanoidiQ75CW5.
KOiK00415.
OMAiYITLKAT.
OrthoDBiEOG7F51BJ.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q75CW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSQRLQCSK QFARHLSVAA KDGSGKVSTL SVQVQGGSRY ATKDGVAHLL
60 70 80 90 100
SRFNFHNTGN KSALRLVRES ELLGGRFQST VDREHITLSA TFLKEDLPYF
110 120 130 140 150
VNALADVLYK TSFRPHELAE SVLPAATRDA AVARACPVAA AEEALYSVTY
160 170 180 190 200
RHGLGKPVLY DGVEKVTLED IKAYADKVYT KENVTVLGQG INEADLKRFV
210 220 230 240 250
NDSLLASLPS GTSLAGSGNA KTHSGEARLR HAGSSVAAIA VPVAKADFAT
260 270 280 290 300
YEVLARYLTS DLYALSPLVH KAKLDKYTDG GLFSLYVKSA EAAKAAADIK
310 320 330 340 350
KVVADLKAGK DISVARKYAA LQLAVENDSA ASPVSLKLEN AKDFKLGKFN
360
YVAVGDVSNL PFADEL
Length:366
Mass (Da):39,229
Last modified:January 9, 2013 - v2
Checksum:iB0A46B5B605A15D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016816 Genomic DNA. Translation: AAS51029.2.
RefSeqiNP_983205.2. NM_208558.2.

Genome annotation databases

EnsemblFungiiAAS51029; AAS51029; AGOS_ACL199C.
GeneIDi4619325.
KEGGiago:AGOS_ACL199C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016816 Genomic DNA. Translation: AAS51029.2.
RefSeqiNP_983205.2. NM_208558.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi33169.AGOS_ACL199C.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS51029; AAS51029; AGOS_ACL199C.
GeneIDi4619325.
KEGGiago:AGOS_ACL199C.

Phylogenomic databases

eggNOGiCOG0612.
HOGENOMiHOG000159494.
InParanoidiQ75CW5.
KOiK00415.
OMAiYITLKAT.
OrthoDBiEOG7F51BJ.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 19; 108; 110; 269; 274; 281; 283; 297; 313-314; 323; 330 AND 346.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiQCR2_ASHGO
AccessioniPrimary (citable) accession number: Q75CW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 9, 2013
Last modified: March 4, 2015
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.