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Q75CP6

- 3HAO_ASHGO

UniProt

Q75CP6 - 3HAO_ASHGO

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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

BNA1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451DioxygenUniRule annotation
Metal bindingi49 – 491Iron; catalyticUniRule annotation
Metal bindingi55 – 551Iron; catalyticUniRule annotation
Binding sitei55 – 551SubstrateUniRule annotation
Metal bindingi98 – 981Iron; catalyticUniRule annotation
Binding sitei102 – 1021SubstrateUniRule annotation
Binding sitei112 – 1121SubstrateUniRule annotation
Metal bindingi127 – 1271Divalent metal cationUniRule annotation
Metal bindingi130 – 1301Divalent metal cationUniRule annotation
Metal bindingi164 – 1641Divalent metal cationUniRule annotation
Metal bindingi167 – 1671Divalent metal cationUniRule annotation

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Biosynthesis of nicotinic acid protein 1UniRule annotation
Gene namesi
Name:BNA1UniRule annotation
Ordered Locus Names:ACL127W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome III

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1801803-hydroxyanthranilate 3,4-dioxygenasePRO_0000245471Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi33169.AGOS_ACL127W.

Structurei

3D structure databases

ProteinModelPortaliQ75CP6.
SMRiQ75CP6. Positions 1-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiNOG77058.
HOGENOMiHOG000218448.
InParanoidiQ75CP6.
KOiK00452.
OMAiHINQTPE.
OrthoDBiEOG7QK0Q0.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q75CP6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNTTPINID AWLAENSHLL QPPVNNFCLH RGGFTVMLVG GPNERTDYHV
60 70 80 90 100
NPTPEWFYQK TGAMTLRIVD EQLSGAARFR DVTIREGDSF LLPANVPHNP
110 120 130 140 150
VRYADTVGIV VEQDRPAGHF DQLRWYCRGC RELVCKYEFY MSDLSSQVRE
160 170 180
GIERFAASAE DRVCKHCGTL NYPTPQASAT
Length:180
Mass (Da):20,378
Last modified:July 5, 2004 - v1
Checksum:i24B84FC51F52BA85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016816 Genomic DNA. Translation: AAS51101.1.
RefSeqiNP_983277.1. NM_208630.1.

Genome annotation databases

EnsemblFungiiAAS51101; AAS51101; AGOS_ACL127W.
GeneIDi4619397.
KEGGiago:AGOS_ACL127W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016816 Genomic DNA. Translation: AAS51101.1 .
RefSeqi NP_983277.1. NM_208630.1.

3D structure databases

ProteinModelPortali Q75CP6.
SMRi Q75CP6. Positions 1-176.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_ACL127W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAS51101 ; AAS51101 ; AGOS_ACL127W .
GeneIDi 4619397.
KEGGi ago:AGOS_ACL127W.

Phylogenomic databases

eggNOGi NOG77058.
HOGENOMi HOG000218448.
InParanoidi Q75CP6.
KOi K00452.
OMAi HINQTPE.
OrthoDBi EOG7QK0Q0.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry namei3HAO_ASHGO
AccessioniPrimary (citable) accession number: Q75CP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3