Reviewed, UniProtKB/Swiss-Prot Q75CP6 (3HAO_ASHGO)

Names and origin

Protein names

Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenase
    EC=1.13.11.6
Alternative name(s):
    3-hydroxyanthranilic acid dioxygenase
    3-hydroxyanthranilate oxygenase
      Short name=3-HAO

Gene names

Name:	BNA1
Ordered Locus Names:	ACL127W

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde.
Cofactor	Fe(2+) ion By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; pyridine-2,3-dicarboxylate from L-kynurenine: step 3/3.
Sequence similarities	Belongs to the 3-HAO family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-hydroxyanthranilate 3,4-dioxygenase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	3-hydroxyanthranilate 3,4-dioxygenase		PRO_0000245471
Sites
	Metal binding	49	1	Iron; catalytic By similarity
	Metal binding	55	1	Iron; catalytic By similarity
	Metal binding	98	1	Iron; catalytic By similarity
	Metal binding	127	1	Divalent metal cation By similarity
	Metal binding	130	1	Divalent metal cation By similarity
	Metal binding	164	1	Divalent metal cation By similarity
	Metal binding	167	1	Divalent metal cation By similarity
	Binding site	45	1	Dioxygen By similarity
	Binding site	55	1	Substrate By similarity
	Binding site	102	1	Substrate By similarity
	Binding site	112	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q75CP6-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 24B84FC51F52BA85	FASTA	180	20,378
	10 20 30 40 50 60 MLNTTPINID AWLAENSHLL QPPVNNFCLH RGGFTVMLVG GPNERTDYHV NPTPEWFYQK 70 80 90 100 110 120 TGAMTLRIVD EQLSGAARFR DVTIREGDSF LLPANVPHNP VRYADTVGIV VEQDRPAGHF 130 140 150 160 170 180 DQLRWYCRGC RELVCKYEFY MSDLSSQVRE GIERFAASAE DRVCKHCGTL NYPTPQASAT

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016816 Genomic DNA. Translation: AAS51101.1.
RefSeq	NP_983277.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4619397.
KEGG	ago:AGOS_ACL127W.
NMPDR	fig|33169.1.peg.922.
Organism-specific databases
AGD	ACL127W.
Phylogenomic databases
HOGENOM	Q75CP6.
Family and domain databases
InterPro	IPR010329. 3hydroanth_dOase. [Graphical view]
Pfam	PF06052. 3-HAO. 1 hit. [Graphical view]
TIGRFAMs	TIGR03037. anthran_nbaC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

3HAO_ASHGO

Accession

Primary (citable) accession number: Q75CP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	July 5, 2004
Last modified:	November 25, 2008
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)