Reviewed, UniProtKB/Swiss-Prot Q75CH3 (ATG1_ASHGO)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase ATG1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	ATG1
Ordered Locus Names:	ACL054W

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	972 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 972	972	Serine/threonine-protein kinase ATG1		PRO_0000085638
Regions
	Domain	18 – 319	302	Protein kinase
	Nucleotide binding	24 – 32	9	ATP By similarity
Sites
	Active site	166	1	Proton acceptor By similarity
	Binding site	48	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q75CH3-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F2EFF374025DDFAE	FASTA	972	109,057
	10 20 30 40 50 60 MNNVKSGGRP VAIVAERYVV EKEIGRGSFA VVYKGHLADS SAGNVAIKAV SRSKLRNKKL 70 80 90 100 110 120 LENLEIEIAI LKKIKHPHIV GLLECERTGT DFYLMMEYCA LGDLTFFIKK RRSLMDKHPL 130 140 150 160 170 180 VRTLFEKYPP PSEHHNGLNR VLVVNYLQQL SSALKFLRSK NLVHRDIKPQ NLLLSTPLVD 190 200 210 220 230 240 YNDPAEFHAR GFVGIYNLPI LKIADFGFAR FLPNTSLAET LCGSPLYMAP EILNYQKYNA 250 260 270 280 290 300 KADLWSVGTV LYEMCCGKPP FKASNHLELF QKIKKANDVI QFPKHAALES AMVDLICGLL 310 320 330 340 350 360 TFEPAKRMGF TEFFSNGLVN EDLSPYEVES EPDLETKSKN VAESNMFISE YLPTAERNKR 370 380 390 400 410 420 ASPIRLGDSC TLRGPCESPQ GADPYPQDNT QSDQHEHLHA DYSFQVEMGQ DGQQADGEEK 430 440 450 460 470 480 RKLYNNQEER SNEERQFGQV SNGRNQEDQL LLHQGRGQIP CEQNRQALQS HSHVAAKQIP 490 500 510 520 530 540 DKDSKSSVSC QKHAASAPTK NDHRTTRLKE KTKCSYSDLL LEKEYVVVEK KSVEVNALAD 550 560 570 580 590 600 EFAQAGSGAP AIRLPDQHHN DASQALQMAR HSSTSVSAAN TAKQTLLRRN SRTLSSSGAS 610 620 630 640 650 660 TSRRPSLVDR RLSITSLGAT NALSKALGMA SLRLFGNSHQ QSSNGSSTFK QNPNVTSLLS 670 680 690 700 710 720 PQTFQDMTEN AVLSADHQWD NSRQADVLHD DSIMKALENL TAKVYAIYSF AEVKFSQIIP 730 740 750 760 770 780 LPPSSTQDPY THKRMSNGSC AIDDEEDDIE HSPGAETYRK NSSGANANTG NYNFSLDTIH 790 800 810 820 830 840 EMNLNDLPPN DLYILCTEAI VLYMKSLSLL AYAMHLTSKW WHESADKICP LKLNLLVQWI 850 860 870 880 890 900 RERFNECLEK AEFLRMKTQS IQLHNGNQLS ASTMVSEPVF VEKLIYDRAL DISKTAAKME 910 920 930 940 950 960 MQGEYLEGCE VAYSTSLWML EALLDDVSDE DNYNDDNLGH TGVLDKSDKE VIKRYIDSIA 970 NRLKALRRKL SR

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016816 Genomic DNA. Translation: AAS51174.1.
RefSeq	NP_983350.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4619475.
KEGG	ago:AGOS_ACL054W.
NMPDR	fig|33169.1.peg.995.
Organism-specific databases
AGD	ACL054W.
Phylogenomic databases
HOGENOM	Q75CH3.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_ASHGO

Accession

Primary (citable) accession number: Q75CH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	July 5, 2004
Last modified:	November 25, 2008
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)