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Reviewed, UniProtKB/Swiss-Prot Q75CA4 (DNLI4_ASHGO)

Last modified November 25, 2008. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    DNA ligase 4
    EC=6.5.1.1
Alternative name(s):
    DNA ligase IV
    Polydeoxyribonucleotide synthase [ATP] 4
Gene names
Name: LIG4
Ordered Locus Names: ACR008W
OrganismAshbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]
Taxonomic identifier33169 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium

Protein attributes

Sequence length981 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining By similarity.

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

Subcellular location

NucleusBy similarity.

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Contains 2 BRCT domains.

Ontologies

Keywords

   Biological processDNA damage
DNA recombination
DNA repair
DNA replication
   Cellular componentNucleus
   DomainRepeat
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processDNA recombination

Inferred from electronic annotation. Source: InterPro

DNA repair

Inferred from electronic annotation. Source: InterPro

DNA replication

Inferred from electronic annotation. Source: InterPro

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: InterPro

DNA ligase (ATP) activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 981981DNA ligase 4
PRO_0000278374

Regions

Domain721 – 81999BRCT 1
Domain875 – 980106BRCT 2

Sites

Active site3221N6-AMP-lysine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q75CA4-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 9883B3EEDACA8A25

FASTA981111,881
        10         20         30         40         50         60 
MVIYPWLKNT TELTIALPKK PIIHANMDVL GSPRGGTPTG EHEINAQDGS PINFSPSPDF 

        70         80         90        100        110        120 
CWLCDELFIK LEEVALKKKD LGKPRKVRNL EITSNFVSLW RKTVGNDIYP ALVLSLPYND 

       130        140        150        160        170        180 
RRSYRVKDVT LVKALCKHMK LPRNSETERR LLHWKQNAPR GVKLSTFCVE ELQKRRREPV 

       190        200        210        220        230        240 
VPKRMSIDEV NGMLDKLEHE SNVGKWSYIS LAESPAFNYC LEHMSYVELR FFFDIVLKVP 

       250        260        270        280        290        300 
IVSGLESLLL SCWHPDAESY FKVVSDLRIV AHTLYDPNER LEKNDLSVRI GYAFAPHMAQ 

       310        320        330        340        350        360 
RVKIPYEKVS TKLGNDFYVE EKMDGDRIQV HYMDYGNSIA YFSRNGINYT YLYGENSSKG 

       370        380        390        400        410        420 
SISNHLKFVE GVKECILDGE MVSYDKEMQC ILPFGLTKSG ASHQVNFETT GHTEPTYRPL 

       430        440        450        460        470        480 
YAVFDLLYLN GQLLTNQDVV KRKEYLEKIL IPSKNVVHLL SGPRCSDAEA ITAALGAAVA 

       490        500        510        520        530        540 
HGSEGIVLKK ARSKYSVGKR DDSWIKIKPE YLENFGENMD LVVIGRDKGR KDSFICALAV 

       550        560        570        580        590        600 
TDDSEKNNPS SYESGSDSDS DSEPIIVQPK IEKFISFCSI ANGISNEEFK EIDRLTRGNW 

       610        620        630        640        650        660 
FPYDERKPPT DWVEFGTKTP REWIDPKNSV VLEVKARSID NEESKSDLYK TGSTLYNAYC 

       670        680        690        700        710        720 
KRIRHDKNWS TASTVAEYDT AREARSYFNV SQNAKFGKDR SSPRKRRTFH LVGDIDVTKP 

       730        740        750        760        770        780 
SKADFLKGYY FYVTSGYFDL QSKKNIDASE IGEAVVSCGG TYIHNLRIRA SLDKLYILGC 

       790        800        810        820        830        840 
KDTRELKMLI ERGYDIIHPE WLMDCVKYGT MLQIEPKYVY SASEELMKQA RNQEDKYGES 

       850        860        870        880        890        900 
YQLPVTEDTL KALANKQVEE GYASEMGTDA VSEYERLLIF KGWLFYILDD YAYHSSWSDI 

       910        920        930        940        950        960 
VKWNIESCGG EVTNDLELAT IVVAVKDCFS QLSLQAVRNN IGARITGSND VQPIPKIVTS 

       970        980 
EWVEACMEAQ YLVDEDEYAA I 

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References

[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed: 15001715] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51.

Cross-references

Sequence databases

AE016816 Genomic DNA. Translation: AAS51235.1.
RefSeqNP_983411.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4619536.
KEGGago:AGOS_ACR008W.
NMPDRfig|33169.1.peg.1056.

Organism-specific databases

AGDACR008W.

Phylogenomic databases

HOGENOMQ75CA4.

Family and domain databases

InterProIPR001357. BRCT.
IPR000977. DNA_ligase.
IPR012310. DNA_ligase_A_M.
IPR016059. DNA_ligase_CS.
IPR012340. NA-bd_OB-fold.
[Graphical view]
Gene3DG3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PfamPF00533. BRCT. 2 hits.
PF01068. DNA_ligase_A_M. 1 hit.
[Graphical view]
SMARTSM00292. BRCT. 2 hits.
[Graphical view]
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI4_ASHGO
AccessionPrimary (citable) accession number: Q75CA4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: November 25, 2008
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents