Q75C99 (HAT2_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone acetyltransferase type B subunit 2

Gene names

Name:	HAT2
Ordered Locus Names:	ACR017W

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing By similarity.
Subunit structure	Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. Contains 6 WD repeats.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm Nucleus
Domain	Repeat WD repeat
Molecular function	Chromatin regulator
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 423	423	Histone acetyltransferase type B subunit 2		PRO_0000227732
Regions
	Repeat	138 – 174	37	WD 1
	Repeat	175 – 224	50	WD 2
	Repeat	228 – 268	41	WD 3
	Repeat	271 – 311	41	WD 4
	Repeat	315 – 355	41	WD 5
	Repeat	372 – 412	41	WD 6

Sequences

	Sequence		Length	Mass (Da)
	Q75C99 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 56AA85D269F99CF5	FASTA	423	46,854
	10 20 30 40 50 60 MTTKLKGLKE LGNTSDPLRT VSYQVRTKMS DYEDDNTDVQ SLTVEEEYEL WNSNVPVMYE 70 80 90 100 110 120 FVSETKLTWP SLTIQWLPSD GQSPEQSLIF GTHTAGEEVN YLKVATINLP AGIAGLDQGD 130 140 150 160 170 180 EEDEANDHSS FAIANKFPHI EEVIRARYMP ANSNIIATIN GKGTISIFDR TLEESKAQVS 190 200 210 220 230 240 TLAFHKENGY GLAFNPHISG ELLSGSDDTT VALWDIEAAK KPKSILTSHD DIVNDVKWHE 250 260 270 280 290 300 FESNVFGTVS EDKTLQVHDK RVRLEPVKKL PTASPFNTLS FSKHSRNLLA AAGVDSQIYL 310 320 330 340 350 360 YDMRDMSSPL HVMSGHQDSV TTVEFSPHTD GIICSSGSDR RAIIWDLTQI GAEQSQDDAD 370 380 390 400 410 420 DGAPELMMMH AGHRSPVNEF SFNPQIPWLL ASTEEDNVIQ AWKVSMKLVN ASPPAISDPS LLV

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016816 Genomic DNA. Translation: AAS51244.1.
RefSeq	NP_983420.1. NM_208773.1.
3D structure databases
ProteinModelPortal	Q75C99.
ModBase	Search...
Protein-protein interaction databases
STRING	Q75C99.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4619545.
GenomeReviews	Gene locus ACR017W in contig AE016816_GR.
KEGG	ago:AGOS_ACR017W.
NMPDR	fig|33169.1.peg.1065.
Organism-specific databases
AGD	ACR017W.
Phylogenomic databases
eggNOG	fuNOG07048.
HOGENOM	HBG435352.
OMA	NDEEPDI.
OrthoDB	EOG412QFD.
PhylomeDB	Q75C99.
Family and domain databases
InterPro	IPR022052. Histone-bd_RBBP4. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KO	K10752.
Pfam	PF12265. CAF1C_H4-bd. 1 hit. PF00400. WD40. 4 hits. [Graphical view]
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 3 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HAT2_ASHGO

Accession

Primary (citable) accession number: Q75C99

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program