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Q75C78

- GRP78_ASHGO

UniProt

Q75C78 - GRP78_ASHGO

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Protein

78 kDa glucose-regulated protein homolog

Gene

KAR2

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

GO - Molecular functioni

  1. ATPase activity Source: EnsemblFungi
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: EnsemblFungi
  2. karyogamy involved in conjugation with cellular fusion Source: EnsemblFungi
  3. posttranslational protein targeting to membrane, translocation Source: EnsemblFungi
  4. response to unfolded protein Source: EnsemblFungi
  5. SRP-dependent cotranslational protein targeting to membrane, translocation Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name:
BIP
Gene namesi
Name:KAR2
Ordered Locus Names:ACR038W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome III

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. luminal surveillance complex Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 67464078 kDa glucose-regulated protein homologPRO_0000013576Add
BLAST

Proteomic databases

PRIDEiQ75C78.

Interactioni

Protein-protein interaction databases

STRINGi33169.AGOS_ACR038W.

Structurei

3D structure databases

ProteinModelPortaliQ75C78.
SMRiQ75C78. Positions 47-585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi671 – 6744Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228135.
InParanoidiQ75C78.
KOiK09490.
OMAiCWIALLF.
OrthoDBiEOG728916.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q75C78-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFGKVSNWA VPLTALMYAM ALVCLPMFAG GSRGLVYAAD TDAENYGTVI
60 70 80 90 100
GIDLGTTYSC VALMRNGKTE ILANEQGNRI TPSYVAFTDD ERLIGDAAKN
110 120 130 140 150
QVANNPKNTI FDIKRLIGLK YNDKTVQREI KHLPFEVVDK NGMPAVAVTV
160 170 180 190 200
KGERKLFTPE EISGMVLGKM KQIAEEYLGK KVTHAVVTVP AYFNDAQRQA
210 220 230 240 250
TKDAGAIAGL NILRIVNEPT AAAIAYGLDK TEDEHRIVVY DLGGGTFDVS
260 270 280 290 300
LLSIENGVFE VQATAGDTHL GGEDFDYKLV RHFLKVFKKK HGVDVSSNAK
310 320 330 340 350
AMAKLKREAE KAKRALSSQM STRVEIDSFV DGIDFSETLT RAKFEEMNLD
360 370 380 390 400
LFKRTLKPVE KVLQDAGLKK EDIDDIVLVG GSTRIPKVQE LLENFFNKKA
410 420 430 440 450
SKGINPDEAV AYGAAVQAGV LSGEEGVEDI VLLDVNPLTL GIEVTGGIMT
460 470 480 490 500
PLIKRNTPIP TKKSQIFSTA VDNQKTVMIQ VYEGERAMAK DNNHLGKFEL
510 520 530 540 550
SGIPPAPRGI PQIEVTFALD ANGILKVSAT DKGTGKSESV TITNEKGRLS
560 570 580 590 600
KDDIERMVAE AENYQKEDEE IRAKVEARHK LENYAHSLKN QVNGDLGDKL
610 620 630 640 650
EEDDKETLLE AANDVLEWLE DNSDSATKEE FNEKFESLSQ TAYPITSKLY
660 670
GAGASDATDD EDDESDDYFD HDEL
Length:674
Mass (Da):73,898
Last modified:July 5, 2004 - v1
Checksum:iEA3DCF15A5A48547
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016816 Genomic DNA. Translation: AAS51265.1.
RefSeqiNP_983441.1. NM_208794.1.

Genome annotation databases

EnsemblFungiiAAS51265; AAS51265; AGOS_ACR038W.
GeneIDi4619566.
KEGGiago:AGOS_ACR038W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016816 Genomic DNA. Translation: AAS51265.1 .
RefSeqi NP_983441.1. NM_208794.1.

3D structure databases

ProteinModelPortali Q75C78.
SMRi Q75C78. Positions 47-585.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_ACR038W.

Proteomic databases

PRIDEi Q75C78.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAS51265 ; AAS51265 ; AGOS_ACR038W .
GeneIDi 4619566.
KEGGi ago:AGOS_ACR038W.

Phylogenomic databases

eggNOGi COG0443.
HOGENOMi HOG000228135.
InParanoidi Q75C78.
KOi K09490.
OMAi CWIALLF.
OrthoDBi EOG728916.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiGRP78_ASHGO
AccessioniPrimary (citable) accession number: Q75C78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3