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Q75C78

- GRP78_ASHGO

UniProt

Q75C78 - GRP78_ASHGO

Protein

78 kDa glucose-regulated protein homolog

Gene

KAR2

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

    GO - Molecular functioni

    1. ATPase activity Source: EnsemblFungi
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. ER-associated ubiquitin-dependent protein catabolic process Source: EnsemblFungi
    2. karyogamy involved in conjugation with cellular fusion Source: EnsemblFungi
    3. posttranslational protein targeting to membrane, translocation Source: EnsemblFungi
    4. response to unfolded protein Source: EnsemblFungi
    5. SRP-dependent cotranslational protein targeting to membrane, translocation Source: EnsemblFungi

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    78 kDa glucose-regulated protein homolog
    Short name:
    GRP-78
    Alternative name(s):
    Immunoglobulin heavy chain-binding protein homolog
    Short name:
    BIP
    Gene namesi
    Name:KAR2
    Ordered Locus Names:ACR038W
    OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
    Taxonomic identifieri284811 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
    ProteomesiUP000000591: Chromosome III

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. luminal surveillance complex Source: EnsemblFungi

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 67464078 kDa glucose-regulated protein homologPRO_0000013576Add
    BLAST

    Proteomic databases

    PRIDEiQ75C78.

    Interactioni

    Protein-protein interaction databases

    STRINGi33169.AGOS_ACR038W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ75C78.
    SMRiQ75C78. Positions 47-585.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi671 – 6744Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0443.
    HOGENOMiHOG000228135.
    KOiK09490.
    OMAiCWIALLF.
    OrthoDBiEOG728916.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q75C78-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFGKVSNWA VPLTALMYAM ALVCLPMFAG GSRGLVYAAD TDAENYGTVI    50
    GIDLGTTYSC VALMRNGKTE ILANEQGNRI TPSYVAFTDD ERLIGDAAKN 100
    QVANNPKNTI FDIKRLIGLK YNDKTVQREI KHLPFEVVDK NGMPAVAVTV 150
    KGERKLFTPE EISGMVLGKM KQIAEEYLGK KVTHAVVTVP AYFNDAQRQA 200
    TKDAGAIAGL NILRIVNEPT AAAIAYGLDK TEDEHRIVVY DLGGGTFDVS 250
    LLSIENGVFE VQATAGDTHL GGEDFDYKLV RHFLKVFKKK HGVDVSSNAK 300
    AMAKLKREAE KAKRALSSQM STRVEIDSFV DGIDFSETLT RAKFEEMNLD 350
    LFKRTLKPVE KVLQDAGLKK EDIDDIVLVG GSTRIPKVQE LLENFFNKKA 400
    SKGINPDEAV AYGAAVQAGV LSGEEGVEDI VLLDVNPLTL GIEVTGGIMT 450
    PLIKRNTPIP TKKSQIFSTA VDNQKTVMIQ VYEGERAMAK DNNHLGKFEL 500
    SGIPPAPRGI PQIEVTFALD ANGILKVSAT DKGTGKSESV TITNEKGRLS 550
    KDDIERMVAE AENYQKEDEE IRAKVEARHK LENYAHSLKN QVNGDLGDKL 600
    EEDDKETLLE AANDVLEWLE DNSDSATKEE FNEKFESLSQ TAYPITSKLY 650
    GAGASDATDD EDDESDDYFD HDEL 674
    Length:674
    Mass (Da):73,898
    Last modified:July 5, 2004 - v1
    Checksum:iEA3DCF15A5A48547
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016816 Genomic DNA. Translation: AAS51265.1.
    RefSeqiNP_983441.1. NM_208794.1.

    Genome annotation databases

    EnsemblFungiiAAS51265; AAS51265; AGOS_ACR038W.
    GeneIDi4619566.
    KEGGiago:AGOS_ACR038W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016816 Genomic DNA. Translation: AAS51265.1 .
    RefSeqi NP_983441.1. NM_208794.1.

    3D structure databases

    ProteinModelPortali Q75C78.
    SMRi Q75C78. Positions 47-585.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33169.AGOS_ACR038W.

    Proteomic databases

    PRIDEi Q75C78.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAS51265 ; AAS51265 ; AGOS_ACR038W .
    GeneIDi 4619566.
    KEGGi ago:AGOS_ACR038W.

    Phylogenomic databases

    eggNOGi COG0443.
    HOGENOMi HOG000228135.
    KOi K09490.
    OMAi CWIALLF.
    OrthoDBi EOG728916.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
      Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
      Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
    2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
      Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
      G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

    Entry informationi

    Entry nameiGRP78_ASHGO
    AccessioniPrimary (citable) accession number: Q75C78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3