Reviewed, UniProtKB/Swiss-Prot Q75BV4 (LYS1_ASHGO)

Names and origin

Protein names

Recommended name:
    Saccharopine dehydrogenase [NAD+, L-lysine-forming]
      Short name=SDH
    EC=1.5.1.7
Alternative name(s):
    Lysine--2-oxoglutarate reductase

Gene names

Name:	LYS1
Ordered Locus Names:	ACR167C

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungi route): step 3/3.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the AlaDH/PNT family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Lysine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lysine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro saccharopine dehydrogenase (NAD+, L-lysine-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	Saccharopine dehydrogenase [NAD+, L-lysine-forming]		PRO_0000199009
Sites
	Active site	204	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q75BV4-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 6A6B7154788F1799	FASTA	372	40,974
	10 20 30 40 50 60 MSAILHLRAE TKPMEARAAL TPTTVRTLVS HGFKIYVEES AQSVFEAAEY AAAGAEVVAT 70 80 90 100 110 120 GSWRGAPRER IIVGLKELPE EDTFPLEHTH IQFAHCYKNQ SGWREVLGRF QSGGGLLYDL 130 140 150 160 170 180 EFLQDDRGRR VAAFGYYAGF AGAALGLRDW AWKQTHTDAE DLPAVAPYEN EQALVSEVAA 190 200 210 220 230 240 ACEEAYKKGA RKPRVLVIGA LGRCGSGAVE LLRQCGLHDK HIIRWDIAET ARGGPFPEIA 250 260 270 280 290 300 AADIFINCIY LSQPIAPFIN MELLDRPDRK LRTIVDVSAD TTNPHNPVPV YNVATVFSSP 310 320 330 340 350 360 TVVVPTSQGP KLSVISIDHL PSLLPREASE AFASDLLPSL LQLPERDTAP VWLRAKELFQ 370 QHCERLSKEA RL

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016816 Genomic DNA. Translation: AAS51393.1.
RefSeq	NP_983569.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4619701.
KEGG	ago:AGOS_ACR167C.
NMPDR	fig|33169.1.peg.1214.
Organism-specific databases
AGD	ACR167C.
Phylogenomic databases
HOGENOM	Q75BV4.
OMA	Q75BV4. IGALGRC.
Enzyme and pathway databases
BRENDA	1.5.1.7. 279361.
Family and domain databases
InterPro	IPR007698. Ala_DH/PNT_C. IPR007886. Ala_DH/PNT_N. [Graphical view]
Pfam	PF01262. AlaDh_PNT_C. 1 hit. PF05222. AlaDh_PNT_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LYS1_ASHGO

Accession

Primary (citable) accession number: Q75BV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)