Q75BV4 (LYS1_ASHGO) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 54.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Saccharopine dehydrogenase [NAD+, L-lysine-forming] Short name=SDH EC=1.5.1.7 Alternative name(s): Lysine--2-oxoglutarate reductase | ||||
| Gene names |
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| Organism | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Complete proteome] | ||||
| Taxonomic identifier | 284811 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium |
Protein attributes
| Sequence length | 372 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH. |
| Pathway | |
| Subunit structure | Monomer By similarity. |
| Sequence similarities | Belongs to the AlaDH/PNT family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Lysine biosynthesis |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | lysine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | saccharopine dehydrogenase (NAD+, L-lysine-forming) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE016816 Genomic DNA. Translation: AAS51393.1. |
| RefSeq | NP_983569.1. NM_208922.1. |
3D structure databases | |
| ProteinModelPortal | Q75BV4. |
| SMR | Q75BV4. Positions 2-372. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q75BV4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 4619701. |
| GenomeReviews | Gene locus ACR167C in contig AE016816_GR. |
| KEGG | ago:AGOS_ACR167C. |
| NMPDR | fig|33169.1.peg.1214. |
Organism-specific databases | |
| AGD | ACR167C. |
Phylogenomic databases | |
| eggNOG | fuNOG07631. |
| HOGENOM | HBG331053. |
| OMA | QFAHCYK. |
| OrthoDB | EOG408RHS. |
| PhylomeDB | Q75BV4. |
Family and domain databases | |
| InterPro | IPR007886. AlaDH/PNT_N. IPR007698. AlaDH/PNT_NAD(H)-bd. [Graphical view] |
| KO | K00290. |
| Pfam | PF01262. AlaDh_PNT_C. 1 hit. PF05222. AlaDh_PNT_N. 1 hit. [Graphical view] |
| SMART | SM01002. AlaDh_PNT_C. 1 hit. SM01003. AlaDh_PNT_N. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LYS1_ASHGO | ||||||||
| Accession | Primary (citable) accession number: Q75BV4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with