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Q75BB3

- LYS2_ASHGO

UniProt

Q75BB3 - LYS2_ASHGO

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Protein

L-aminoadipate-semialdehyde dehydrogenase large subunit

Gene

LYS2

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH.By similarity

Catalytic activityi

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.

Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 1 phosphopantetheine covalently.Curated

Pathwayi

GO - Molecular functioni

  1. L-aminoadipate-semialdehyde dehydrogenase activity Source: UniProtKB-EC
  2. phosphopantetheine binding Source: InterPro

GO - Biological processi

  1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00033; UER00032.

Names & Taxonomyi

Protein namesi
Recommended name:
L-aminoadipate-semialdehyde dehydrogenase large subunit (EC:1.2.1.31)
Alternative name(s):
Alpha-aminoadipate reductase
Short name:
Alpha-AR
Gene namesi
Name:LYS2
Ordered Locus Names:ADL346W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome IV

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13851385L-aminoadipate-semialdehyde dehydrogenase large subunitPRO_0000193148Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei880 – 8801O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRIDEiQ75BB3.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.By similarity

Protein-protein interaction databases

STRINGi33169.AGOS_ADL346W.

Structurei

3D structure databases

ProteinModelPortaliQ75BB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini848 – 91770Acyl carrierPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 acyl carrier domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG3320.
HOGENOMiHOG000191209.
InParanoidiQ75BB3.
KOiK00143.
OrthoDBiEOG74TX6Z.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR010071. AA_adenyl_domain.
IPR009081. Acyl_carrier_prot-like.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR014397. L-NH2adipate-semiAld_DH_lsu.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR010080. Thioester_reductase-like_dom.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF001617. Alpha-AR. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR03443. alpha_am_amid. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75BB3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCAVLEPSMI RWLSEVDNIV VSSLPSDYIP SGPAGVKAES CEVELPGSFG
60 70 80 90 100
VIDEEDSYIR LLSAFATLVC RMSGESDVAM YSKANRLLKL AVPPGVAFQQ
110 120 130 140 150
LRASVTEAVE GTLALPAVDF DELSALEREK KQLDYYPQYF KVGVVTAADK
160 170 180 190 200
TKLDQFRYHK FELLLRQVTS SRFEMVYDSE RFSPDRIGEL GEQLVQFLTL
210 220 230 240 250
VEAKDDADVY AISLVTSGAS RVLPDPTTDL GWGQFRGAIH DIFQHHAETR
260 270 280 290 300
PDRLCVVETG VGQVAARTFT YSAINCASNI VAHYLLARGI RRGDVVMIYS
310 320 330 340 350
TRGVDLLVSV LGVLKSGAVF SVIDPAYPPA RQNVYLGVAK PAGLIVIQAA
360 370 380 390 400
GQLDEAVEAF IRDNLSLKAR LPALALQTDG AILGGTLPDF HLDTLVPFAS
410 420 430 440 450
LKNTRTDVVV GPDSNPTLSF TSGSEGIPKG VLGRHFSLTY YFDWMAKRFG
460 470 480 490 500
LSEDDKFTML SGIAHDPIQR DMFTPIYLGA QLLVPQEDDI GTPGRLATWM
510 520 530 540 550
ATHGATVTHL TPAMGQVLTA DATTPFPSLK RAFFVGDVLT KRDCARLQSL
560 570 580 590 600
AENVAIVNMY GSTETQRAVS YFEVPSCSSN PSYLDNLKSI IPAGRGMHNV
610 620 630 640 650
QLLIVNRHDR TKLCGIGEVG EIYVRAGGLS EGYRGLPEIN KEKFIDNWFV
660 670 680 690 700
DAGHWGGLDL SGDEPWRNYW LGVRDRLYRT GDLGRYLPNG DCECCGRADD
710 720 730 740 750
QVKIRGFRIE LGEIDTNISQ YPLCRENITL LRKDQNGEST LISYLVPRSD
760 770 780 790 800
QKALASFISA VPESIATESI AGSLIKYHKL INDIRGFLKK RLAGYAIPTL
810 820 830 840 850
IMVMERLPLN PNGKIDKNKL QFPEPTELDR ASEHFASETL GLSSFSPLEQ
860 870 880 890 900
EIRKIWLDLL PTRPAITSSD ESFFDLGGTS ILATRMAIVL RNRLNISLAL
910 920 930 940 950
STIFRYPTVK ELAKEISRVR GTISDDKSSN SGTTEYYADA KHVSEAELAS
960 970 980 990 1000
KYESRLSLLP SGATSAPVYV FLTGVTGFLG CHILADLLNR SRKPYDITVY
1010 1020 1030 1040 1050
AHVRASDESS ALQRIKSVCT AYGLWKNAYA PRIKVVLGNL AEKQFGLPKK
1060 1070 1080 1090 1100
AWHDLQEGID VIIHNAALVH WVYPYSKLRE ANVLSTVNVL NLAAAGKAKY
1110 1120 1130 1140 1150
FTFVSSTSAL DTKHYLELSN AAIESGGSGV PEDDDLMGGS LGLKGGYGQS
1160 1170 1180 1190 1200
KWAAEFIIKR AGERGLRGCI LRPGYVTGSP STGASNADDF LLRFLRGCVQ
1210 1220 1230 1240 1250
LGKIPDIEGT VNMVPVDYVA RLATAASFSS SGNTHMMVVN VNAKPRISFR
1260 1270 1280 1290 1300
DYLLALKEYG YQVTSVPYDE WSKALESSSD EENPLYPLLY LVLDDLPKKL
1310 1320 1330 1340 1350
RSPELDTTNA KFVLEEDFAR TNIEPIIITS VSLEVVGSYI SFLHKLGFLE
1360 1370 1380
EPAKGSRPLP NISLSDEQIS LIAAVATARS STAKP
Length:1,385
Mass (Da):151,953
Last modified:January 9, 2013 - v2
Checksum:iDE96D1018986F338
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016817 Genomic DNA. Translation: AAS51573.2.
RefSeqiNP_983749.2. NM_209102.2.

Genome annotation databases

GeneIDi4619884.
KEGGiago:AGOS_ADL346W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016817 Genomic DNA. Translation: AAS51573.2 .
RefSeqi NP_983749.2. NM_209102.2.

3D structure databases

ProteinModelPortali Q75BB3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_ADL346W.

Proteomic databases

PRIDEi Q75BB3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4619884.
KEGGi ago:AGOS_ADL346W.

Phylogenomic databases

eggNOGi COG3320.
HOGENOMi HOG000191209.
InParanoidi Q75BB3.
KOi K00143.
OrthoDBi EOG74TX6Z.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00032 .

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR010071. AA_adenyl_domain.
IPR009081. Acyl_carrier_prot-like.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR014397. L-NH2adipate-semiAld_DH_lsu.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR010080. Thioester_reductase-like_dom.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view ]
PIRSFi PIRSF001617. Alpha-AR. 1 hit.
SUPFAMi SSF47336. SSF47336. 1 hit.
TIGRFAMsi TIGR01733. AA-adenyl-dom. 1 hit.
TIGR03443. alpha_am_amid. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 543-570; 575; 578; 587 AND 591.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiLYS2_ASHGO
AccessioniPrimary (citable) accession number: Q75BB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 9, 2013
Last modified: November 26, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3