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Q75BB3

- LYS2_ASHGO

UniProt

Q75BB3 - LYS2_ASHGO

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Protein
L-aminoadipate-semialdehyde dehydrogenase large subunit
Gene
LYS2, ADL346W
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH By similarity.

Catalytic activityi

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.

Cofactori

Binds 1 phosphopantetheine covalently Reviewed prediction.

Pathwayi

GO - Molecular functioni

  1. L-aminoadipate-semialdehyde dehydrogenase activity Source: UniProtKB-EC
  2. phosphopantetheine binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00033; UER00032.

Names & Taxonomyi

Protein namesi
Recommended name:
L-aminoadipate-semialdehyde dehydrogenase large subunit (EC:1.2.1.31)
Alternative name(s):
Alpha-aminoadipate reductase
Short name:
Alpha-AR
Gene namesi
Name:LYS2
Ordered Locus Names:ADL346W
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome IV

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13851385L-aminoadipate-semialdehyde dehydrogenase large subunit
PRO_0000193148Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei880 – 8801O-(pantetheine 4'-phosphoryl)serine Reviewed prediction

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRIDEiQ75BB3.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit By similarity.

Protein-protein interaction databases

STRINGi33169.AGOS_ADL346W.

Structurei

3D structure databases

ProteinModelPortaliQ75BB3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini848 – 91770Acyl carrier
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3320.
HOGENOMiHOG000191209.
KOiK00143.
OrthoDBiEOG74TX6Z.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR010071. AA_adenyl_domain.
IPR009081. Acyl_carrier_prot-like.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR014397. L-NH2adipate-semiAld_DH_lsu.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR010080. Thioester_reductase-like_dom.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF001617. Alpha-AR. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR03443. alpha_am_amid. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q75BB3-1 [UniParc]FASTAAdd to Basket

« Hide

MCAVLEPSMI RWLSEVDNIV VSSLPSDYIP SGPAGVKAES CEVELPGSFG     50
VIDEEDSYIR LLSAFATLVC RMSGESDVAM YSKANRLLKL AVPPGVAFQQ 100
LRASVTEAVE GTLALPAVDF DELSALEREK KQLDYYPQYF KVGVVTAADK 150
TKLDQFRYHK FELLLRQVTS SRFEMVYDSE RFSPDRIGEL GEQLVQFLTL 200
VEAKDDADVY AISLVTSGAS RVLPDPTTDL GWGQFRGAIH DIFQHHAETR 250
PDRLCVVETG VGQVAARTFT YSAINCASNI VAHYLLARGI RRGDVVMIYS 300
TRGVDLLVSV LGVLKSGAVF SVIDPAYPPA RQNVYLGVAK PAGLIVIQAA 350
GQLDEAVEAF IRDNLSLKAR LPALALQTDG AILGGTLPDF HLDTLVPFAS 400
LKNTRTDVVV GPDSNPTLSF TSGSEGIPKG VLGRHFSLTY YFDWMAKRFG 450
LSEDDKFTML SGIAHDPIQR DMFTPIYLGA QLLVPQEDDI GTPGRLATWM 500
ATHGATVTHL TPAMGQVLTA DATTPFPSLK RAFFVGDVLT KRDCARLQSL 550
AENVAIVNMY GSTETQRAVS YFEVPSCSSN PSYLDNLKSI IPAGRGMHNV 600
QLLIVNRHDR TKLCGIGEVG EIYVRAGGLS EGYRGLPEIN KEKFIDNWFV 650
DAGHWGGLDL SGDEPWRNYW LGVRDRLYRT GDLGRYLPNG DCECCGRADD 700
QVKIRGFRIE LGEIDTNISQ YPLCRENITL LRKDQNGEST LISYLVPRSD 750
QKALASFISA VPESIATESI AGSLIKYHKL INDIRGFLKK RLAGYAIPTL 800
IMVMERLPLN PNGKIDKNKL QFPEPTELDR ASEHFASETL GLSSFSPLEQ 850
EIRKIWLDLL PTRPAITSSD ESFFDLGGTS ILATRMAIVL RNRLNISLAL 900
STIFRYPTVK ELAKEISRVR GTISDDKSSN SGTTEYYADA KHVSEAELAS 950
KYESRLSLLP SGATSAPVYV FLTGVTGFLG CHILADLLNR SRKPYDITVY 1000
AHVRASDESS ALQRIKSVCT AYGLWKNAYA PRIKVVLGNL AEKQFGLPKK 1050
AWHDLQEGID VIIHNAALVH WVYPYSKLRE ANVLSTVNVL NLAAAGKAKY 1100
FTFVSSTSAL DTKHYLELSN AAIESGGSGV PEDDDLMGGS LGLKGGYGQS 1150
KWAAEFIIKR AGERGLRGCI LRPGYVTGSP STGASNADDF LLRFLRGCVQ 1200
LGKIPDIEGT VNMVPVDYVA RLATAASFSS SGNTHMMVVN VNAKPRISFR 1250
DYLLALKEYG YQVTSVPYDE WSKALESSSD EENPLYPLLY LVLDDLPKKL 1300
RSPELDTTNA KFVLEEDFAR TNIEPIIITS VSLEVVGSYI SFLHKLGFLE 1350
EPAKGSRPLP NISLSDEQIS LIAAVATARS STAKP 1385
Length:1,385
Mass (Da):151,953
Last modified:January 9, 2013 - v2
Checksum:iDE96D1018986F338
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016817 Genomic DNA. Translation: AAS51573.2.
RefSeqiNP_983749.2. NM_209102.2.

Genome annotation databases

GeneIDi4619884.
KEGGiago:AGOS_ADL346W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016817 Genomic DNA. Translation: AAS51573.2 .
RefSeqi NP_983749.2. NM_209102.2.

3D structure databases

ProteinModelPortali Q75BB3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_ADL346W.

Proteomic databases

PRIDEi Q75BB3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4619884.
KEGGi ago:AGOS_ADL346W.

Phylogenomic databases

eggNOGi COG3320.
HOGENOMi HOG000191209.
KOi K00143.
OrthoDBi EOG74TX6Z.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00032 .

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR010071. AA_adenyl_domain.
IPR009081. Acyl_carrier_prot-like.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR014397. L-NH2adipate-semiAld_DH_lsu.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR010080. Thioester_reductase-like_dom.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view ]
PIRSFi PIRSF001617. Alpha-AR. 1 hit.
SUPFAMi SSF47336. SSF47336. 1 hit.
TIGRFAMsi TIGR01733. AA-adenyl-dom. 1 hit.
TIGR03443. alpha_am_amid. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 543-570; 575; 578; 587 AND 591.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiLYS2_ASHGO
AccessioniPrimary (citable) accession number: Q75BB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 9, 2013
Last modified: February 19, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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