Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q75BB3 (LYS2_ASHGO)

Last modified November 25, 2008. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    L-aminoadipate-semialdehyde dehydrogenase large subunit
    EC=1.2.1.31
Alternative name(s):
    Alpha-aminoadipate reductase
      Short name=Alpha-AR
Gene names
Name: LYS2
Ordered Locus Names: ADL346W
OrganismAshbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]
Taxonomic identifier33169 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium

Protein attributes

Sequence length1385 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH By similarity.

Catalytic activity

L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H.

Cofactor

Binds 1 phosphopantetheine covalently Potential.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungi route): step 1/3.

Subunit structure

Heterodimer of an alpha and a beta subunit By similarity.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Contains 1 acyl carrier domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13851385L-aminoadipate-semialdehyde dehydrogenase large subunit
PRO_0000193148

Regions

Domain848 – 91770Acyl carrier

Sites

Binding site8801Phosphopantetheine (covalent) Potential

Sequences

Sequence LengthMass (Da)Tools
Q75BB3-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: E79042C26C9A9623

FASTA1,385152,306
        10         20         30         40         50         60 
MCAVLEPSMI RWLSEVDNIV VSSLPSDYIP SGPAGVKAES CEVELPGSFG VIDEEDSYIR 

        70         80         90        100        110        120 
LLSAFATLVC RMSGESDVAM YSKANRLLKL AVPPGVAFQQ LRASVTEAVE GTLALPAVDF 

       130        140        150        160        170        180 
DELSALEREK KQLDYYPQYF KVGVVTAADK TKLDQFRYHK FELLLRQVTS SRFEMVYDSE 

       190        200        210        220        230        240 
RFSPDRIGEL GEQLVQFLTL VEAKDDADVY AISLVTSGAS RVLPDPTTDL GWGQFRGAIH 

       250        260        270        280        290        300 
DIFQHHAETR PDRLCVVETG VGQVAARTFT YSAINCASNI VAHYLLARGI RRGDVVMIYS 

       310        320        330        340        350        360 
TRGVDLLVSV LGVLKSGAVF SVIDPAYPPA RQNVYLGVAK PAGLIVIQAA GQLDEAVEAF 

       370        380        390        400        410        420 
IRDNLSLKAR LPALALQTDG AILGGTLPDF HLDTLVPFAS LKNTRTDVVV GPDSNPTLSF 

       430        440        450        460        470        480 
TSGSEGIPKG VLGRHFSLTY YFDWMAKRFG LSEDDKFTML SGIAHDPIQR DMFTPIYLGA 

       490        500        510        520        530        540 
QLLVPQEDDI GTPGRLATWM ATHGATVTHL TPAMGQVLTA DATTPFPSLK RAFFVGDVLT 

       550        560        570        580        590        600 
KRTVHDYSLW LKTWPLLTCT AHLEPSVQYR YFEVQSCCSN PSYLDNVKSI TPAGRGMHNV 

       610        620        630        640        650        660 
QLLIVNRHDR TKLCGIGEVG EIYVRAGGLS EGYRGLPEIN KEKFIDNWFV DAGHWGGLDL 

       670        680        690        700        710        720 
SGDEPWRNYW LGVRDRLYRT GDLGRYLPNG DCECCGRADD QVKIRGFRIE LGEIDTNISQ 

       730        740        750        760        770        780 
YPLCRENITL LRKDQNGEST LISYLVPRSD QKALASFISA VPESIATESI AGSLIKYHKL 

       790        800        810        820        830        840 
INDIRGFLKK RLAGYAIPTL IMVMERLPLN PNGKIDKNKL QFPEPTELDR ASEHFASETL 

       850        860        870        880        890        900 
GLSSFSPLEQ EIRKIWLDLL PTRPAITSSD ESFFDLGGTS ILATRMAIVL RNRLNISLAL 

       910        920        930        940        950        960 
STIFRYPTVK ELAKEISRVR GTISDDKSSN SGTTEYYADA KHVSEAELAS KYESRLSLLP 

       970        980        990       1000       1010       1020 
SGATSAPVYV FLTGVTGFLG CHILADLLNR SRKPYDITVY AHVRASDESS ALQRIKSVCT 

      1030       1040       1050       1060       1070       1080 
AYGLWKNAYA PRIKVVLGNL AEKQFGLPKK AWHDLQEGID VIIHNAALVH WVYPYSKLRE 

      1090       1100       1110       1120       1130       1140 
ANVLSTVNVL NLAAAGKAKY FTFVSSTSAL DTKHYLELSN AAIESGGSGV PEDDDLMGGS 

      1150       1160       1170       1180       1190       1200 
LGLKGGYGQS KWAAEFIIKR AGERGLRGCI LRPGYVTGSP STGASNADDF LLRFLRGCVQ 

      1210       1220       1230       1240       1250       1260 
LGKIPDIEGT VNMVPVDYVA RLATAASFSS SGNTHMMVVN VNAKPRISFR DYLLALKEYG 

      1270       1280       1290       1300       1310       1320 
YQVTSVPYDE WSKALESSSD EENPLYPLLY LVLDDLPKKL RSPELDTTNA KFVLEEDFAR 

      1330       1340       1350       1360       1370       1380 
TNIEPIIITS VSLEVVGSYI SFLHKLGFLE EPAKGSRPLP NISLSDEQIS LIAAVATARS 


STAKP 

« Hide

References

[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed: 15001715] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51.

Cross-references

Sequence databases

AE016817 Genomic DNA. Translation: AAS51573.1.
RefSeqNP_983749.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4619884.
KEGGago:AGOS_ADL346W.
NMPDRfig|33169.1.peg.1394.

Organism-specific databases

AGDADL346W.

Phylogenomic databases

HOGENOMQ75BB3.

Family and domain databases

InterProIPR010071. AA_adenyl_dom.
IPR000873. AMP-dep_Synth/Lig.
IPR014397. L-NH2adipate-semiAld_DH_lsu.
IPR013120. Male_sterile_NAD-bd.
IPR006163. Phsphopanteth_bd.
IPR006162. Ppantne_S.
IPR010080. Thioester_reductase.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
PIRSFPIRSF001617. Alpha-AR. 1 hit.
TIGRFAMsTIGR01733. AA-adenyl-dom. 1 hit.
TIGR03443. alpha_am_amid. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEPS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
PS00012. PHOSPHOPANTETHEINE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYS2_ASHGO
AccessionPrimary (citable) accession number: Q75BB3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: November 25, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents