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Q75BB3

- LYS2_ASHGO

UniProt

Q75BB3 - LYS2_ASHGO

Protein

L-aminoadipate-semialdehyde dehydrogenase large subunit

Gene

LYS2

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (09 Jan 2013)
      Previous versions | rss
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    Functioni

    Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH.By similarity

    Catalytic activityi

    (S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.

    Cofactori

    Binds 1 phosphopantetheine covalently.Curated

    Pathwayi

    GO - Molecular functioni

    1. L-aminoadipate-semialdehyde dehydrogenase activity Source: UniProtKB-EC
    2. phosphopantetheine binding Source: InterPro

    GO - Biological processi

    1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00033; UER00032.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-aminoadipate-semialdehyde dehydrogenase large subunit (EC:1.2.1.31)
    Alternative name(s):
    Alpha-aminoadipate reductase
    Short name:
    Alpha-AR
    Gene namesi
    Name:LYS2
    Ordered Locus Names:ADL346W
    OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
    Taxonomic identifieri284811 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
    ProteomesiUP000000591: Chromosome IV

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13851385L-aminoadipate-semialdehyde dehydrogenase large subunitPRO_0000193148Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei880 – 8801O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation

    Keywords - PTMi

    Phosphopantetheine, Phosphoprotein

    Proteomic databases

    PRIDEiQ75BB3.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit.By similarity

    Protein-protein interaction databases

    STRINGi33169.AGOS_ADL346W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ75BB3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini848 – 91770Acyl carrierPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 acyl carrier domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG3320.
    HOGENOMiHOG000191209.
    KOiK00143.
    OrthoDBiEOG74TX6Z.

    Family and domain databases

    Gene3Di1.10.1200.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR010071. AA_adenyl_domain.
    IPR009081. Acyl_carrier_prot-like.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    IPR014397. L-NH2adipate-semiAld_DH_lsu.
    IPR013120. Male_sterile_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR010080. Thioester_reductase-like_dom.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF07993. NAD_binding_4. 1 hit.
    PF00550. PP-binding. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001617. Alpha-AR. 1 hit.
    SUPFAMiSSF47336. SSF47336. 1 hit.
    TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
    TIGR03443. alpha_am_amid. 1 hit.
    TIGR01746. Thioester-redct. 1 hit.
    PROSITEiPS50075. ACP_DOMAIN. 1 hit.
    PS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q75BB3-1 [UniParc]FASTAAdd to Basket

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    MCAVLEPSMI RWLSEVDNIV VSSLPSDYIP SGPAGVKAES CEVELPGSFG     50
    VIDEEDSYIR LLSAFATLVC RMSGESDVAM YSKANRLLKL AVPPGVAFQQ 100
    LRASVTEAVE GTLALPAVDF DELSALEREK KQLDYYPQYF KVGVVTAADK 150
    TKLDQFRYHK FELLLRQVTS SRFEMVYDSE RFSPDRIGEL GEQLVQFLTL 200
    VEAKDDADVY AISLVTSGAS RVLPDPTTDL GWGQFRGAIH DIFQHHAETR 250
    PDRLCVVETG VGQVAARTFT YSAINCASNI VAHYLLARGI RRGDVVMIYS 300
    TRGVDLLVSV LGVLKSGAVF SVIDPAYPPA RQNVYLGVAK PAGLIVIQAA 350
    GQLDEAVEAF IRDNLSLKAR LPALALQTDG AILGGTLPDF HLDTLVPFAS 400
    LKNTRTDVVV GPDSNPTLSF TSGSEGIPKG VLGRHFSLTY YFDWMAKRFG 450
    LSEDDKFTML SGIAHDPIQR DMFTPIYLGA QLLVPQEDDI GTPGRLATWM 500
    ATHGATVTHL TPAMGQVLTA DATTPFPSLK RAFFVGDVLT KRDCARLQSL 550
    AENVAIVNMY GSTETQRAVS YFEVPSCSSN PSYLDNLKSI IPAGRGMHNV 600
    QLLIVNRHDR TKLCGIGEVG EIYVRAGGLS EGYRGLPEIN KEKFIDNWFV 650
    DAGHWGGLDL SGDEPWRNYW LGVRDRLYRT GDLGRYLPNG DCECCGRADD 700
    QVKIRGFRIE LGEIDTNISQ YPLCRENITL LRKDQNGEST LISYLVPRSD 750
    QKALASFISA VPESIATESI AGSLIKYHKL INDIRGFLKK RLAGYAIPTL 800
    IMVMERLPLN PNGKIDKNKL QFPEPTELDR ASEHFASETL GLSSFSPLEQ 850
    EIRKIWLDLL PTRPAITSSD ESFFDLGGTS ILATRMAIVL RNRLNISLAL 900
    STIFRYPTVK ELAKEISRVR GTISDDKSSN SGTTEYYADA KHVSEAELAS 950
    KYESRLSLLP SGATSAPVYV FLTGVTGFLG CHILADLLNR SRKPYDITVY 1000
    AHVRASDESS ALQRIKSVCT AYGLWKNAYA PRIKVVLGNL AEKQFGLPKK 1050
    AWHDLQEGID VIIHNAALVH WVYPYSKLRE ANVLSTVNVL NLAAAGKAKY 1100
    FTFVSSTSAL DTKHYLELSN AAIESGGSGV PEDDDLMGGS LGLKGGYGQS 1150
    KWAAEFIIKR AGERGLRGCI LRPGYVTGSP STGASNADDF LLRFLRGCVQ 1200
    LGKIPDIEGT VNMVPVDYVA RLATAASFSS SGNTHMMVVN VNAKPRISFR 1250
    DYLLALKEYG YQVTSVPYDE WSKALESSSD EENPLYPLLY LVLDDLPKKL 1300
    RSPELDTTNA KFVLEEDFAR TNIEPIIITS VSLEVVGSYI SFLHKLGFLE 1350
    EPAKGSRPLP NISLSDEQIS LIAAVATARS STAKP 1385
    Length:1,385
    Mass (Da):151,953
    Last modified:January 9, 2013 - v2
    Checksum:iDE96D1018986F338
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016817 Genomic DNA. Translation: AAS51573.2.
    RefSeqiNP_983749.2. NM_209102.2.

    Genome annotation databases

    GeneIDi4619884.
    KEGGiago:AGOS_ADL346W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016817 Genomic DNA. Translation: AAS51573.2 .
    RefSeqi NP_983749.2. NM_209102.2.

    3D structure databases

    ProteinModelPortali Q75BB3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33169.AGOS_ADL346W.

    Proteomic databases

    PRIDEi Q75BB3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4619884.
    KEGGi ago:AGOS_ADL346W.

    Phylogenomic databases

    eggNOGi COG3320.
    HOGENOMi HOG000191209.
    KOi K00143.
    OrthoDBi EOG74TX6Z.

    Enzyme and pathway databases

    UniPathwayi UPA00033 ; UER00032 .

    Family and domain databases

    Gene3Di 1.10.1200.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR010071. AA_adenyl_domain.
    IPR009081. Acyl_carrier_prot-like.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    IPR014397. L-NH2adipate-semiAld_DH_lsu.
    IPR013120. Male_sterile_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR010080. Thioester_reductase-like_dom.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF07993. NAD_binding_4. 1 hit.
    PF00550. PP-binding. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001617. Alpha-AR. 1 hit.
    SUPFAMi SSF47336. SSF47336. 1 hit.
    TIGRFAMsi TIGR01733. AA-adenyl-dom. 1 hit.
    TIGR03443. alpha_am_amid. 1 hit.
    TIGR01746. Thioester-redct. 1 hit.
    PROSITEi PS50075. ACP_DOMAIN. 1 hit.
    PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
      Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
      Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
    2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
      Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
      G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 543-570; 575; 578; 587 AND 591.
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

    Entry informationi

    Entry nameiLYS2_ASHGO
    AccessioniPrimary (citable) accession number: Q75BB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: January 9, 2013
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3